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Method for measuring blood flow velocity by utilization of radiography microbubbles

A blood flow velocity and microbubble technology, applied in blood flow measurement devices, image analysis, image enhancement, etc., can solve the problems of cumbersome and repetitive manual measurement methods, and achieve the effects of high repeatability and simple measurement methods.

Inactive Publication Date: 2014-06-04
WUHAN UNIV
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  • Application Information

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Problems solved by technology

[0004] Aiming at the cumbersome and poor repeatability of the manual measurement method, the present invention proposes an automatic method for measuring blood flow velocity through ultrasonic microbubbles. At the same time, aiming at the characteristic that more than one contrast microbubble is injected into the blood vessel, multiple Contrast microbubbles and automatically track them separately, the method has high accuracy
So far, no automated method for measuring blood flow velocity using ultrasonic microbubbles has been reported

Method used

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  • Method for measuring blood flow velocity by utilization of radiography microbubbles
  • Method for measuring blood flow velocity by utilization of radiography microbubbles
  • Method for measuring blood flow velocity by utilization of radiography microbubbles

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Effect test

Embodiment 1

[0050] Example 1: Tracking Velocimetry of a Single Microbubble

[0051] By tracking individual ultrasound microbubbles, the blood flow velocity of simulated vessels and perihepatic vessels in vitro were measured, respectively. In the experiment, ultrasound contrast-enhanced microbubbles were injected into simulated blood vessels in vitro and blood vessels near the liver, and video images of microbubble movement were recorded. Through the algorithm proposed by the invention, the moving microbubble is detected, tracked and measured.

[0052] figure 2 (a)(b) are two adjacent frames of images containing contrast microbubbles in the in vitro simulated blood vessel video, and the arrow points to the position of the target microbubble; figure 2 (c) is the image after target segmentation by anisotropic diffusion filter and improved inter-frame difference algorithm.

[0053] extract figure 2 The moving target template in (c), calculate the LBP texture characteristic histogram of...

Embodiment 2

[0056] Embodiment 2: Tracking Velocimetry of Multiple Microbubbles

[0057] The blood flow velocity in the rabbit ear blood vessel was measured by respectively tracking two contrast microbubbles in the rabbit ear blood vessel. For the tracking speed measurement of multiple microbubbles, the implementation method is the same as that in Embodiment 1. Two target microbubble templates are respectively extracted through preprocessing and moving target segmentation algorithms, and their LBP texture histograms are respectively calculated for tracking and matching. The obtained velocity values ​​and motion trajectories of the two microbubbles in each frame are as follows: Image 6 As shown, the comparison of the measurement results and the error analysis are as follows Figure 7 shown. It can be seen that the tracking of the two microbubbles does not interfere with each other, and the measurement error is also about 4%.

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Abstract

The invention discloses a method for measuring blood flow velocity by the utilization of radiography microbubbles. The method includes the following steps of ultrasonic video frame image preprocessing, moving ultrasound microbubble target segmentation, moving ultrasound microbubble matching and tracking and blood flow velocity measurement. The method has the advantages of being simple to operate, high in repeatability and applicability and the like, the blood flow velocity measured through the method is very close to the blood flow velocity measured through a manual method, and the average error is only about four percent. According to the method, the blood flow velocity in a blood vessel is measured accurately, and therefore the method has important significance in studying early signs or the intermediate link of attack of some diseases.

Description

technical field [0001] The invention relates to a method for measuring blood flow velocity by using contrast microbubbles, and belongs to the technical field of ultrasonic image processing. Background technique [0002] The blood flow velocity in blood vessels is an important parameter and indicator of human health, which can reflect the intermediate links or early signs of many diseases. Therefore, accurately measuring the blood flow velocity in blood vessels can help doctors analyze the condition better, which has important clinical value and significance. [0003] With the development of ultrasound contrast agents, second harmonic imaging technology has been well used. Microbubbles made of lipids, polymers, or biochemical proteins filled with inert gas are noninvasive. The target structure with ideal effect can be obtained by using the harmonic or sub-harmonic imaging instrument made of contrast microbubbles that can generate strong visible second harmonic signals for d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/20G06T5/40A61B8/06
Inventor 张东陈定坤陈放陈庭寅杨艳
Owner WUHAN UNIV
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