Neomycin sulfate solution and preparation method thereof

Abstract

The invention discloses a neomycin sulfate solution comprising the following ingredients by weight percent: 5-30% of neomycin sulfate, 0.5-1% of vitamin C, 0.5-1% of sorbitol, 0.1-1% of vanillin and the balance of water. The invention also discloses a preparation method of the neomycin sulfate solution. The neomycin sulfate solution disclosed by the invention is simple in preparation, convenient to use, and long in storage time.

Description

technical field [0001] The invention relates to a neomycin sulfate solution and a preparation method thereof, belonging to the field of preparations. Background technique [0002] Neomycin sulfate is the second clinical application of aminoglycoside antibiotics, and it is a commonly used veterinary drug abroad. Neomycin sulfate interferes with the synthesis of bacterial proteins by acting on the ribosomes associated with the bacterial cell membrane, and only needs a short contact with the bacteria to kill them. After oral administration, the gastrointestinal absorption is extremely poor, and it is mainly distributed in the extracellular fluid in the body, with a low binding rate to plasma proteins (≤20%). It is not metabolized in the body and is excreted in the original form. Therefore, there is no residue in the body, no toxic and side effects to animals, and it is very safe to take orally. [0003] Indications: [0004] 1. This product is an aminoglycoside antibiotic dr...

AI Technical Summary

Problems solved by technology

[0006] At present, there are relatively few dosage forms of neomycin sulfate, and there are few alternative routes of administration, which cannot meet the needs of clinical use.