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Probiotic for administration to healthy young mammals during the weaning period for improving tolerance to newly introduced food stuffs

A technology for mammals and probiotics, applied in the directions of bacteria, food science, and the function of food ingredients used in food preparation, can solve problems such as low consumption, and achieve the effect of preventing severe discomfort and pathological states

Inactive Publication Date: 2014-06-18
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thus, the consumption of immunoprotective compounds found in human milk is low when they are most needed and the factors are not fully available by the immune system of young mammals

Method used

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  • Probiotic for administration to healthy young mammals during the weaning period for improving tolerance to newly introduced food stuffs
  • Probiotic for administration to healthy young mammals during the weaning period for improving tolerance to newly introduced food stuffs
  • Probiotic for administration to healthy young mammals during the weaning period for improving tolerance to newly introduced food stuffs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Example 1: Piglet model to study the influence of Bifidobacterium lactis NCC2818 at weaning

[0090] 2 experiments were performed.

[0091] In the first experiment according to the feeding scheme I ( figure 1 A), Piglets were suckled by their mothers during the first three weeks of life. At week 3, the animals were weaned to a solid diet with protein content based on soy supplemented with Bifidobacterium lactis (NCC2818) or non-supplemented soy, or to an unsupplemented ovalbumin (OVA) diet . All animals were switched to a fishmeal diet at week 7, and one group was continuously supplemented with B. lactis NCC2818. Animals were sacrificed at week 11.

[0092] Whole-body soybean-specific IgG levels were measured on days 0, 7, and 14 after weaning ( figure 2 ), IgA, IgM and CD21 levels in mesenteric lymph node (MLN) cells were examined at sacrifice ( Figure 4 ).

[0093] In the second experiment according to feeding scheme II ( figure 1 B), Piglets were fed formul...

Embodiment 2

[0116] start recipe

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Embodiment 3

[0121] growing up milk composition

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[0123] Additional supporting evidence for the present invention can be found in the paper "Weaning diet induces sustained metabolic phenotype shift in the pig and influences host response to Bifidobacterium lactis NCC2818C" (Merrifield and M. Lewis et al., 2012, Gut doi:10.1136 / gutjnl-2011-301656) , which is hereby incorporated by reference. With particular reference to Merrifield and M. Lewis et al. image 3 , Figure A. The data presented in Merrifield and M. Lewis et al. provide evidence that probiotics, particularly Bifidobacterium animalis subsp. lactis, have an effect on immune adaptation when administered to healthy young mammals during the weaning period.

[0124] PCT

[0125] Printed out form (formerly electronic form)

[0126] (This page is not part of the international application and does not count as a page of the international application)

[0127]

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PUM

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Abstract

The current invention is based upon administration of a probiotic, B. Lactis NCC2818 to healthy young mammals during the critical weaning period (in infants this period is usually from about 3 months to about 12, 18 or 24 months old), so as to accelerate the young mammal's adaptation to new food. The effectiveness of the invention is evidenced herein by morphological and immunological changes observed in a piglet animal model of weaning. Thus, administration of the probiotic according to the invention had a prophylactic effect, preventing the severe discomfort and pathological states associated with the introduction to novel foods during the weaning period.

Description

field of invention [0001] This invention relates to improving the tolerance of young mammals, especially human infants, to newly introduced foods during the weaning period by administering a probiotic or a mixture of probiotics. Background of the invention [0002] Nascent post-maturation of the gut immune system [0003] Infants and other young mammals are born with a functional but naive (untrained) intestinal immune system. Full immunity is acquired gradually after birth and can only be achieved through gradual exposure to external stimuli, such as ingested proteins and / or gut microbiota. This gradual immune maturation ultimately leads to the ability to discriminate between noxious and innocuous stimuli and to elicit an appropriate immune response (inflammation when exposed to pathogens, tolerance when exposed to food components and commensal bacteria). Thus, infancy is a period of instability of the immune system with the possibility of two outcomes, leading to toleran...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/30A23L1/308A61K31/702A61K35/74A61K35/745A61K35/747
CPCA23V2200/32A23V2250/284A61K35/745A23L1/308A23V2200/304A61K35/747A23V2250/206A23L1/3014A23Y2300/21A23L33/21A23L33/135A23V2002/00A23V2400/515A23V2250/306A23L33/40A61K31/702
Inventor S·顿克尔M·刘易斯A·梅赛尼尔A·辛格M·贝利
Owner NESTEC SA
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