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New application of desloratadine in pharmacy

A technology of desloratadine and uses, applied in the field of pharmaceutical preparations, can solve problems such as no research report on eczema

Inactive Publication Date: 2014-06-25
HANGZHOU SHARPLY PHARM R&D INSTIT +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And desloratadine topical preparations treat eczema and there is no relevant research report

Method used

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  • New application of desloratadine in pharmacy
  • New application of desloratadine in pharmacy
  • New application of desloratadine in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0078] Embodiment: preparation desloratadine gel

[0079] Desloratadine 2g

[0080] Hydroxypropyl-β-cyclodextrin 8g

[0081] Carbomer 0.85g

[0082] Triethanolamine 0.55g

[0083] Propylene glycol 6g

[0084] Glycerin 12g

[0085] Sodium sulfite 0.1g

[0086] EDTA-2Na 0.1g

[0087] Ethyl p-hydroxybenzoate 0.1g

[0088] Menthol 0.08g

[0089] 95% ethanol 45g

[0090] Water 25.22g

[0091] Made into 100g

[0092] making process

[0093] 1. Dissolve sodium sulfite and EDTA-2Na in water, add glycerin and propylene glycol, mix evenly, add carbomer, stir until evenly dispersed, and obtain phase A;

[0094] 2. Dissolve desloratadine and hydroxypropyl-β-cyclodextrin in ethanol, stir for a period of time, add ethyl p-hydroxybenzoate, menthol, and triethanolamine, and stir evenly to obtain phase B;

[0095] 3. Add item B to item A, stir evenly, and you get it.

Embodiment 2

[0096] Embodiment 2: desloratadine hydrogel

[0097] Desloratadine 2g

[0098] Hydroxypropyl-β-cyclodextrin 8g

[0099] Hypromellose 1.5g

[0100] Propylene glycol 6g

[0101] Glycerin 12g

[0102] Sodium sulfite 0.1g

[0103] EDTA-2Na 0.1g

[0104] Methylparaben 0.1g

[0105] Propylparaben 0.1g

[0106] Azone 2g

[0107] 95% ethanol 20g

[0108] Water 48.2g

[0109] Made into 100g

[0110] making process

[0111] 1. Dissolve sodium sulfite and EDTA-2Na in water, add glycerin and propylene glycol, mix well, add hypromellose, stir until dissolved, and obtain phase A;

[0112] 2. Dissolve desloratadine and hydroxypropyl-β-cyclodextrin in ethanol, stir for a period of time, add methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, and azone, and stir evenly to obtain phase B;

[0113] 3. Add item B to item A, stir evenly, and you get it.

[0114]

[0115] The solubilizer of the present invention uses derivatives of β-cyclodextrin (including hydroxypropyl-β-cyclodext...

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PUM

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Abstract

The invention relates to a new application of desloratadine in pharmacy. The invention discloses the application of desloratadine in preparation of medicines for treating eczema. According to the invention, the application scope of desloratadine is enlarged, and the medication selection for eczema patients is enlarged. The invention also provides an external-use preparation of desloratadine, which solves the problem of the first pass effect generated by oral administration of desloratadine in a traditional mode, and the adverse side-effect generated due to oral administration of desloratadine is reduced.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to desloratadine, and in particular to a new application of desloratadine in pharmacy. Background technique [0002] Desloratadine (desloratadine) is the active metabolite of loratadine (1oratadine) in vivo deformation of ethyl ester. Desloratadine is a new third-generation antihistamine, which can specifically bind to H receptors with high selectivity, has strong anti-allergic effect, rapid onset and long-lasting effect. [0003] Desloratadine is mainly used clinically to treat allergic diseases such as chronic idiopathic urticaria and perennial allergic rhinitis. In addition, it can relieve the symptoms of cold urticaria. [0004] Currently, the dosage forms of desloratadine on the market are mainly oral dosage forms such as tablets, syrups, and dry suspensions. After these preparations are taken, the gastrointestinal tract will have a first-pass effect on the drug, and at the sa...

Claims

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Application Information

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IPC IPC(8): A61K31/4545A61P17/00A61P37/08
Inventor 范敏华孙军刘华陆慧
Owner HANGZHOU SHARPLY PHARM R&D INSTIT
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