Breast injectant prescription of cefquinome sulfate in dry milk period and preparation method thereof

A technology of cefquinoxime sulfate and breast injection, which is applied in the field of veterinary drug preparations, can solve the problems of toxicity accumulation, easy sedimentation of preparations, and high content of main drugs, and achieves the effects of fast onset of action, good drug absorption and good stability

Inactive Publication Date: 2014-07-02
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] "A preparation method of cefquinome sulfate suspension injection (101987100A; publication date: 2011-03-23), the preparation form of this patent is a suspension, which requires multiple administrations, and the preparation is easy to settle. After injecting into the breast chamber, it is easy to form a local main drug content that is too high, and it is easy to form part of the tissue toxicity accumulation in the breast

Method used

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  • Breast injectant prescription of cefquinome sulfate in dry milk period and preparation method thereof

Examples

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Effect test

Embodiment 1

[0028] Example 1: Heat 58.8kg of white mineral oil and maintain it at 80°C, put in 0.6kg of aluminum monostearate, mix the two, stir evenly, then heat to 120°C and maintain for 30min until the two are completely fused, The solution is transparent and clear; the resulting mixed solution is rapidly cooled to 30°C during rapid stirring, and 0.6 kg of sterile cefquinome sulfate micropowder is added thereto under sterile conditions, and sheared by a high homogeneous shearing machine After 30 minutes, the preparation was sheared and dispersed evenly, and then packaged in aseptically sealed form to obtain the finished product.

Embodiment 2

[0029] Example 2: Heat 55.8kg of white mineral oil and maintain it at 80°C, put in 3.0kg of Vaseline, mix the two, stir evenly, then heat to 120°C and maintain for 30min until the two are completely fused, and the solution is transparent and clear In the process of rapid stirring, the resulting mixed solution is rapidly cooled to 30° C., under aseptic conditions, 1.2 kg of sterile cefquinome sulfate micropowder is added therein, and sheared for 30 min by a high homogeneous shearing machine to make the preparation Shear and disperse evenly, pack aseptically and hermetically, and then get the finished product.

Embodiment 3

[0030] Example 3: Heat 51kg of white mineral oil and maintain it at 80°C, put in 6.0kg of hard paraffin, mix the two, stir evenly, then heat to 120°C and maintain for 30min until the two are completely fused, and the solution is transparent and clear In the process of rapid stirring, the resulting mixed solution is rapidly cooled to 30° C., under aseptic conditions, 3.0 kg of sterile cefquinome sulfate micropowder is added therein, and sheared by a high homogeneous shearing machine for 30 minutes to make the preparation Shear and disperse evenly, pack aseptically and hermetically, and then get the finished product.

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PUM

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Abstract

The invention relates to a breast injectant prescription of cefquinome sulfate in a dry milk period and a preparation method thereof. The prescription comprises a suspending aid and a solid dispersing carrier, and is prepared into an almost white and light brown ointment by virtue of a special process. The prescription disclosed by the invention has such advantages as simple preparation process, constant quality, easiness for injection and soft matrix. The prescription, which is in the dosage form of an ointment, has multiple advantages such as high bioavailability, slow release and long action time compared with an injection; the ointment, after being filled into a milk chamber through a milk vessel, can be sealed on a nipple hole, so as to prevent bacteria from moving reversely and invading the milk chamber through the nipple hole and other phenomenons.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a breast injection composition of cefquinome sulfate in dry milk period and a preparation method thereof. Background technique [0002] Cow mastitis is one of the diseases that cause the most serious loss in the dairy industry worldwide. In the United States alone, the loss caused by cow mastitis reaches 200 million US dollars every year. The principle is an inflammatory change that occurs when the mammary gland is stimulated by physical, chemical, or microbial stimulation. Recessive mastitis in dairy cows accounts for a considerable proportion of all mastitis cases and can cause a 4-10% reduction in milk production. According to reports, Staphylococcus aureus, Escherichia coli, and Streptococcus are important pathogenic bacteria that cause mastitis in dairy cows. Tests have proved that cefquinome sulfate ointment has a very good antibacterial effect on d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/546A61P15/14A61P31/04
Inventor 李梁刘拓孙俊
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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