A kind of flutamide sustained-release preparation and preparation method thereof

A sustained-release preparation, flutamide technology, applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of unbalanced release, rapid absorption and slow excretion, and difficulty in achieving sustained release And other issues

Active Publication Date: 2018-02-16
JIANGSU TASLY DIYI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of its rapid absorption and slow excretion, it is difficult to achieve the purpose of sustained release by using the flutamide sustained-release preparation prepared by the prior art. After research, the present invention finds a suitable formula of flutamide sustained-release preparation, which solves the unbalanced release The problem

Method used

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  • A kind of flutamide sustained-release preparation and preparation method thereof
  • A kind of flutamide sustained-release preparation and preparation method thereof
  • A kind of flutamide sustained-release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Flutamide 500 Ethyl cellulose 20g Polyoxyethylene N10 84 Polyoxyethylene N12K 36 Polyvinylpyrrolidone 5 Magnesium stearate 5, the binder used is 6% polyvinylpyrrolidone solution prepared with 95% ethanol

[0034] The preparation process is as follows:

[0035] Polyoxyethylene and polyethylene glycol are mixed evenly, and flutamide is added in equal increments, mixed evenly, added with 6% polyvinylpyrrolidone alcohol solution to granulate, dried, granulated, added lubricant, mixed evenly, and compressed into tablets.

Embodiment 2

[0037] Flutamide 500g Microcrystalline cellulose 20g Polyoxyethylene N10 60g Polyoxyethylene N12K 40g Polyvinylpyrrolidone 5 g Stearic acid 6 g Magnesium stearate 5 g Among them, the binder used is 6% polyvinyl alcohol processed with 95% ethanol Vinylpyrrolidone solution.

[0038] The preparation process is as follows:

[0039] Raw and auxiliary materials are mixed evenly, 6% polyvinylpyrrolidone solution is added to granulate, dried, granulated, lubricant is added, mixed evenly, and tabletted.

Embodiment 3

[0041] Flutamide 500 g Polyoxyethylene 100 g Ethyl cellulose 20 g Polyvinylpyrrolidone 5 g Magnesium stearate 5g, the binder used is 6% polyvinylpyrrolidone solution prepared with 95% ethanol

[0042] The tablet preparation process is as follows:

[0043] Polyoxyethylene and ethyl cellulose are mixed evenly, and flutamide is added in equal increments, mixed evenly, added with 6% polyvinylpyrrolidone solution to granulate, dried, granulated, added lubricant, mixed evenly, and compressed into tablets.

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Abstract

The invention relates to a flutamide sustained-release preparation, which contains the following components by weight percentage:.

Description

Technical field: [0001] The invention relates to the preparation of a pharmaceutical preparation, in particular to a slow-release preparation of an anticancer drug flutamide and a preparation method thereof. Background technique: [0002] Flutamide is an oral nonsteroidal antiandrogen drug mainly used for the treatment of prostate cancer. Prostate cancer is a malignant tumor that occurs in male prostate tissue and is the result of abnormal and disordered growth of prostate acinar cells. Prostate cancer incidence varies markedly by geographic and ethnic origin. In developed countries and regions such as Europe and the United States, it is the most common malignant tumor in men, and its mortality rate ranks second among various cancers; in Asia, its incidence rate is lower than that in Western countries, but it has shown a rapid upward trend in recent years. The incidence rate in my country was low in the past, but due to the aging population, the incidence rate has increase...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K9/00A61K31/167A61K47/32A61K47/38A61K47/10A61P35/00
Inventor 丁爱忠刘金平成芳
Owner JIANGSU TASLY DIYI PHARMA CO LTD
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