Process for synthesizing flutamide

Abstract

The invention discloses a process for synthesizing flutamide. The process comprises the steps of taking 2-nitro-5-aminobenzotrifluoride as a raw material, selecting 1,2-dichloroethane as a solvent and N,N-dimethyl acetamide as an acid absorbent, dropwise adding isobutyryl chloride under the action of 4-dimethylamino pyridine while maintaining the temperature to be 5-10 DEG C, and reacting after the dropwise adding process is completed while maintaining the temperature to be 18-25 DEG C until 2-nitro-5-aminobenzotrifluoride reacts completely; adding water, heating to steam out 1,2-dichloroethane, carrying out elutriation, and filtering to obtain a flutamide crude product; and re-crystallizing by using ethanol, thereby obtaining a flutamide finished product. The process has the advantages of simplicity, few steps, easiness in operation, low cost and high product quality; the conversion ratio of the product is high and reaches over 96%; the activity of a catalyst is high, and side reactions are few; the reaction conditions are mild, and the reaction time is short; the purity of the product is high, and the impurities are few; the production cost is low, and the solvent 1,2-dichloroethane can be repeatedly used indiscriminately; and waste gases, waste water and waste residues are few, thus the environmental friendliness is facilitated.

Description

technical field [0001] The invention relates to a synthesis technique of flutamide, which belongs to the technical field of chemical synthesis techniques. Background technique [0002] There are many synthetic routes for flutamide, and there are two typical production methods. (1) Acylation first and then nitration; (2) First nitration and then acylation. Compared with each other, there are advantages and disadvantages: the advantage of route (1) is that the production process is less; the disadvantage is that the recrystallization is more complicated and the quality is not easy to control. The advantage of route (2) is simple recrystallization and good product quality; the disadvantage is that the production process is more complicated. Contents of the invention [0003] Objective: In order to overcome the deficiencies in the prior art, the present invention provides a synthesis process of flutamide. [0004] Technical solution: In order to solve the above-mentioned te...

AI Technical Summary

Problems solved by technology

Compared with each other, there are advantages and disadvantages: the advantage of route (1) is that there are fewer production processes; the disadvantage is that recrystallization is more complicated and the quality is not easy to control

The advantage of route (2) is that recrystallization is simple and the product quality is good; the disadvantage is that the production process is more complicated

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