Micro/nano-particle-filled optical microfluidic-chip biosensor

A technology of microfluidic chips and biosensors, applied in the field of refractive index testing, can solve problems such as not being good at testing surface refractive index, and achieve the effect of improving test stability

Inactive Publication Date: 2014-07-09
黄辉 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The FP cavity sensor is easy to measure the volume refractive index of the substance in the cavity (that is, the average refractive index of the substance in the cavity), but it is not good at testing the surface refractive index (that is, similar to the SPR sensor to test the refractive index of surface adsorbed substances)

Method used

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  • Micro/nano-particle-filled optical microfluidic-chip biosensor

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0021] First, a structure such as figure 1 The shown microfluidic chip sensor, in which the material of the ball is glass.

[0022] Secondly, the aqueous solution is passed into the optical cavity first, and then the aqueous solution of the substance to be measured is passed through; the substance to be measured will be adsorbed on the inner wall of the cavity and the surface of the bead, thereby changing the overall average refractive index of the substance in the cavity, and the transmittance. The phase of the light wave in the cavity.

[0023] Finally, by testing the phase of the transmitted light wave, the refractive index and composition of the substance to be tested can be obtained.

example 2

[0025] First, fabricate structures on glass substrates such as figure 2 The shown microfluidic chip sensor, in which the material of the ball is organic plastic.

[0026] Secondly, a solution such as dextran is first introduced into the optical cavity, and the dextran molecules will be adsorbed on the inner wall of the cavity and the surface of the bead to improve the adsorption capacity of the inner wall of the cavity and the surface of the bead; The substance to be tested will be adsorbed on the inner wall of the cavity and the surface of the bead, thereby changing the overall average refractive index of the substance in the cavity and the intensity of the light wave passing through the cavity.

[0027] Finally, by testing the intensity of the transmitted light wave, the refractive index and concentration of the substance to be tested can be obtained.

example 3

[0029] First, fabricate structures such as image 3 The shown microfluidic chip sensor, in which the material of the ball is quartz.

[0030] Secondly, the air is introduced into the optical cavity first, and then the air containing alcohol is introduced; the alcohol will be adsorbed on the inner wall of the cavity and the surface of the ball, thereby changing the overall average refractive index of the material in the cavity and the transmission rate through the cavity. The phase of the light wave.

[0031] Finally, by testing the phase of the transmitted light wave, the concentration of alcohol is known.

[0032] In summary, the optical microfluidic chip biosensor provided by the present invention can effectively increase the surface area of ​​the cavity and the adsorption amount of the substance to be tested by filling the cavity with small balls, thereby greatly improving the test sensitivity.

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Abstract

The invention provides a micro/nano-particle-filled optical microfluidic-chip biosensor. The biosensor is characterized in that an optical chamber is filled with small spheres with micro-nano dimension, so that the chamber inner surface area and the surface adsorption quantity are increased, and further the test sensitivity is improved; the chamber can be filled with small spheres with two or more dimension for adjusting the optical chamber surface area and the sphere distance; and the biosensor is applicable to refractive index test of surface adsorbents.

Description

technical field [0001] The invention relates to the refractive index test of gas and liquid samples (such as protein, DNA, antigen, antibody, etc.) in the microfluidic chip, and can be applied to the fields of environmental monitoring, chemical analysis, biomedicine and the like. Background technique [0002] Harmful gas detection has important applications in environmental protection, and liquid detection has important applications in the biomedical field. The microfluidic chip can be used as an ideal channel for carrying gas and liquid samples; and its small size can realize micro-quantity detection and promote the miniaturization, integration and portability of analytical instruments. [0003] The refractive index is an important parameter to reflect the properties of gases and liquids. The type and concentration of the sample can be obtained by testing the refractive index of the sample; and the optical sensor has the characteristics of strong anti-interference ability a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/41G01N21/17
Inventor 黄辉渠波吴海波刘蓬勃
Owner 黄辉
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