Nanotechnology for myocardial infarction diagnosis and device adopting same

A nanotechnology and detection area technology, applied in the field of nanotechnology and its devices, can solve the problems of radioactive pollution, time-consuming, quantitative detection and other problems, and achieve the effect of short detection time and quantitative and accurate detection

Inactive Publication Date: 2014-07-09
QILU UNIV OF TECH
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Problems solved by technology

[0004] Routine detection methods for cardiac troponin I include radioimmunoassays (RIAs), high-pressure liquid chromatography, electrochemical analysis, protein analyzers, various diagnostic kits, and immunochromatographic test strips, etc. These methods have radioactive contamination , the need for large instruments, long time-consuming, quantitative detection and other shortcomings, the clinical application has certain limitations, and it is not easy to popularize and use

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  • Nanotechnology for myocardial infarction diagnosis and device adopting same
  • Nanotechnology for myocardial infarction diagnosis and device adopting same
  • Nanotechnology for myocardial infarction diagnosis and device adopting same

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Embodiment Construction

[0021] Such as figure 1 As shown, the nanotechnology and its device for myocardial infarction diagnosis include a sample application area 1, a reagent storage area 2, a micro channel 3 and a detection area 4 located on the micro channel; the sample application area 1 A filter membrane 5 for filtering the blood cells of the whole blood 8 is provided; the reagent storage area 2 stores anti-human cTnI monoclonal antibody labeled with nano-magnetic beads ( figure 2 shown) and nanofluorescent probe-labeled anti-human cTnI monoclonal antibody ( image 3 shown); the reagent storage area 2 communicates with the detection area 4 through the microchannel 3; a magnetic device 6 is arranged below the detection area 4; a fluorescence detection device 7 is arranged above the detection area 4 . Wherein the magnetic device 6 and the fluorescent detection device 7 adopted are all prior art. In the detection test strip, a waste liquid area 9 is provided in front of the detection area 4 alon...

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Abstract

The invention discloses a nanotechnology for myocardial infarction diagnosis and a device adopting the nanotechnology. The detection device comprises a sample feeding region, a reagent storage region, a micro-channel and a detection region arranged on the micro-channel, wherein the sample feeding region is provided with a filter membrane for filtering blood cells; a nano magnetic bead-marked anti-human cTnI (cardiac troponin I) monoclonal antibody and a nano fluorescent probe-marked anti-human cTnI monoclonal antibody are stored in the reagent storage region; the reagent storage region is communicated with the detection region through the micro-channel; a magnetic device is arranged below the detection region; a fluorescent detection device is arranged above the detection region. The detection device is used for quantitatively detecting cTnI, and is short in detection time, small in size and convenient to carry.

Description

[0001] technical field [0002] The invention relates to a nanotechnology and its device for myocardial infarction diagnosis. Background technique [0003] There are many kinds of myocardial infarction marker proteins, and cardiac troponin I (cTnI) is known as the gold marker protein of myocardial infarction. Troponin is composed of three subunits of troponin I, T, and C, and plays an important regulatory role in the process of muscle contraction and relaxation. When the myocardium is injured, the cardiac troponin complex is released into the blood. Among the three subunits, troponin I has a high degree of myocardial specificity and sensitivity, so cardiac troponin I (cTnI) has become the most ideal markers of myocardial infarction. [0004] Routine detection methods for cardiac troponin I include radioimmunoassays (RIAs), high-pressure liquid chromatography, electrochemical analysis, protein analyzers, various diagnostic kits, and immunochromatographic test strips, etc. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/54366G01N33/6887G01N2333/4712G01N2800/324
Inventor 张丽丽李学林付圳秢
Owner QILU UNIV OF TECH
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