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Extraction method of medicinal position of bark of white birch, and medical use of medicinal position

A technology for medicinal parts and birch bark, which is applied in the field of medicinal parts and extraction of birch bark

Inactive Publication Date: 2014-07-23
BEIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention is the first to obtain the medicinal part of inhibiting DGAT1 from the birch bark. After several pharmacological experiments, it is found that the medicinal part can significantly inhibit the activity of DGAT1 and lower blood lipid. After searching the literature, no such plant has this aspect. report

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Dried chopped birch ( Betula platyphylla Suk) bark 500 g, heated and refluxed with 5 times the amount of 80% methanol to extract 3 times, refluxed for 60 minutes each time, combined the extracts, and recovered the methanol under pressure to obtain a concentrated solution, further placed in an open container to heat and volatilize the methanol, and put Cool, add 1 times the amount of water, a large amount of precipitate precipitates, and extract the concentrate by suction filtration; the concentrate is adjusted to a suspension with 2 times the amount of water, extracted 3 times with 1 times the amount of dichloromethane, combined extracts, and reduced pressure Recover dichloromethane and concentrate until it is difficult to concentrate. Heat it in an open container to evaporate as much dichloromethane as possible, let cool, and dry; the dried product is ground and subjected to 200-300 mesh silica gel column chromatography, firstly with 1-2 Double the amount of n-hexane ...

Embodiment 2

[0043] The difference between this example and Example 1 is that the reflux time is adjusted from 60 minutes to 35 minutes each time, and as a result, 34.7 g of medicinal parts are obtained. Among them, the content of lupeol is 22.08%.

Embodiment 3

[0045] The difference between this example and Example 2 is that each reflux time is adjusted from 35 minutes to 45 minutes, resulting in 35.4 g of medicinal parts. Among them, the content of lupeol is 22.09%.

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PUM

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Abstract

The invention relates to the technical field of medicines, and concretely relates to components having a diacylgycerol acyltransferase inhibition activity and extracted and separated from bark of Betulaceae magaphanerophytes white birch. Results of multi-time in-vitro diacylgycerol acyltransferase (DGAT) inhibition experiments show that the components have an obvious DGAT1 inhibition activity, and can be used for preparing medicines for treating and preventing hyperlipaemia, atherosclerosis and complication thereof. The extraction method is of great significance for developing Chinese medicinal plant resources.

Description

technical field [0001] The invention discloses a medicinal part of white birch bark and an extraction method, and also provides its medical use, and relates to the technical field of traditional Chinese medicine. technical background [0002] Hyperlipidemia mainly refers to the high level of serum total cholesterol (TC) or triacylglycerol (TG) and / or the low level of serum high-density lipoprotein-cholesterol (HDL-C), which cause a series of serious harm to the human body. Healthy disease. With the gradual improvement of people's living standards, changes in diet and lifestyle, and the arrival of population aging, the number of people suffering from hyperlipidemia continues to increase. Studies have shown that hyperlipidemia is the culprit of atherosclerosis, and atherosclerosis is the culprit of cardiovascular and cerebrovascular diseases (angina pectoris, myocardial infarction, hemiplegia). The morbidity and mortality of cardiovascular and cerebrovascular diseases caused...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P3/06A61P9/10A61P3/04A61K129/00
Inventor 崔龙张南李娜李佳琳马坤脱振东邢姗姗
Owner BEIHUA UNIV