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Physical crosslinking PVA/PEO hydrogel orpiment quantum dot transdermal patch and preparation method thereof

A physical cross-linking and hydrogel technology, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve problems such as poor bioavailability of orpiment drugs, and increase bioavailability The effect of promoting biological barrier and improving water retention performance

Active Publication Date: 2014-08-06
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention is to solve the technical problem of poor bioavailability of existing orpiment drugs, and provide a physical cross-linking method to prepare PVA / PEO hydrogel-loaded orpiment quantum dot transdermal patch

Method used

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  • Physical crosslinking PVA/PEO hydrogel orpiment quantum dot transdermal patch and preparation method thereof
  • Physical crosslinking PVA/PEO hydrogel orpiment quantum dot transdermal patch and preparation method thereof

Examples

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specific Embodiment approach 1

[0015] Specific embodiment 1: The physically cross-linked PVA / PEO hydrogel-loaded orpiment quantum dot transdermal patch of this embodiment is that orpiment quantum dots are distributed in the hydrogel formed by physical cross-linking between PVA and PEO, and orpiment The particle diameter of quantum dot is 1~5nm; The sum of the mass of PVA and PEO in this hydrogel is 8%~15% of the mass of this plaster, the ratio of the mass sum of PVA and PEO and the mass of orpiment quantum dot is (5-8): 1, mass ratio of PVA to PEO (15-25): 1.

specific Embodiment approach 2

[0016] Embodiment 2: This embodiment differs from Embodiment 1 in that the thickness of the hydrogel layer is 2 mm to 5 mm. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0017] Specific embodiment three: the preparation method of the physically cross-linked PVA / PEO hydrogel-loaded orpiment quantum dot transdermal patch described in specific embodiment one is carried out according to the following steps:

[0018] 1. Weigh PVA and PEO according to the mass ratio of PVA to PEO (15-25): 1;

[0019] 2. Add PVA to distilled water at a temperature of 90-95°C, stir and dissolve for 2-3 hours, then add PEO, and continue stirring for 1-2 hours to obtain a solution;

[0020] 3. The ratio of the sum of the mass of PVA and PEO in the solution prepared in step 2 to the mass of orpiment quantum dots in the orpiment quantum dot solution is (5-8): 1, and the orpiment quantum dot solution is added to the solution prepared in step 2 , stir evenly to obtain a mixture;

[0021] 4. Inject the mixed solution into the mold, and thaw the mold repeatedly to obtain a physically cross-linked PVA / PEO hydrogel-loaded orpiment quantum dot transdermal patch; the thawing tre...

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Abstract

The invention discloses a physical crosslinking PVA / PEO hydrogel orpiment quantum dot transdermal patch and a preparation method thereof, relates to an orpiment transdermal patch and a preparation method thereof, and aims at the technical problem of poor bioavailability of the existing orpiment drugs. According to the physical crosslinking PVA / PEO hydrogel orpiment quantum dot transdermal patch disclosed by the invention, the orpiment quantum dots are distributed in hydrogel made from PVA and PEO in a physical crosslinking manner. The preparation method comprises the following steps: firstly, preparing the solution of PVA and PEO, and then adding the orpiment quantum dots to the solution, so as to obtain a mixed solution; injecting the mixed solution into a mold, and carrying out repeated freezing treatment on the mold, so as to obtain the physical crosslinking PVA / PEO hydrogel orpiment quantum dot transdermal patch. The equilibrium water content of the transdermal patch is 85-90% and the water absorptivity is 300-380%.

Description

technical field [0001] The invention relates to orpiment transdermal patch and a preparation method thereof. Background technique [0002] Hydrogel patch is a new type of external application agent with wide application range and convenient use. Transdermal drug delivery systems are controlled release formulations that are administered through the skin for systemic therapeutic effects. Compared with general drug treatment, it has unique advantages: ①It adopts biocompatible macromolecular gel matrix, which has good affinity and air permeability to the skin; strong absorption capacity and good moisturizing performance, which is conducive to the rapid transdermal penetration of drugs absorb. ②The drug administration mechanism does not pass through the liver and prevents the digestive system from destroying the drug, reducing the side effects of the drug. ③ The number of administrations is small, the administration is convenient and the curative effect is improved. [0003] ...

Claims

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Application Information

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IPC IPC(8): A61K33/36A61K9/70A61K9/06A61K47/32A61K47/34A61P35/00
Inventor 吴金珠周淑娟邵延斌廖军海那益嘉刘志威梁子坚孙乾
Owner HARBIN INST OF TECH
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