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A kind of montelukast sodium tablet and preparation method thereof

A technology of montelukast sodium tablet and montelukast sodium, applied in the field of medicine, can solve problems such as light sensitivity, and achieve the effects of good stability, simple preparation process and rapid disintegration

Active Publication Date: 2017-05-17
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As for the problem of sensitivity to light, the prior art is to add sunscreen to solve the problem of sensitivity to light

Method used

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  • A kind of montelukast sodium tablet and preparation method thereof
  • A kind of montelukast sodium tablet and preparation method thereof
  • A kind of montelukast sodium tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025]

[0026] Preparation Process:

[0027] Dissolve the montelukast sodium and trehalose in ethanol in the prescribed amount, dry under reduced pressure at 40°C to remove the ethanol, pass the dried product (that is, a dispersion-like compound) through a 60-mesh sieve, and then mix it with the prescribed amount of alginic acid, micro Crystalline cellulose and magnesium stearate are mixed and compressed into tablets.

Embodiment 2

[0029]

[0030] Preparation Process:

[0031] Dissolve the montelukast sodium and trehalose in ethanol in the prescribed amount, dry under reduced pressure at 45°C to remove the ethanol, pass the dried product through an 80-mesh sieve, and then mix with the prescribed amount of alginic acid, microcrystalline cellulose, and magnesium stearate Mix and compress into tablets.

Embodiment 3

[0033]

[0034] Preparation Process:

[0035] Dissolve montelukast sodium and trehalose in ethanol for the prescription amount, place in a rotary evaporator, dry under reduced pressure at 35°C to remove ethanol, pass the dried product through an 80-mesh sieve, and then mix with alginic acid, lactose, Magnesium stearate is blended and compressed into tablets.

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Abstract

The invention provides a montelukast sodium tablet which is prepared by the following method: dissolving montelukast sodium and mycose in alcohol, drying to remove alcohol, and sieving dried substances; then, mixing with alginic acid and pharmaceutically common auxiliary materials, and pressing into tablets. Compared with the prior art, the preparation process disclosed by the invention is simple, and the tablet is quick to disintegrate and good in stability.

Description

technical field [0001] The invention belongs to medical technology, and in particular relates to a montelukast sodium tablet and a preparation method thereof. Background technique [0002] Montelukast sodium is the sodium salt of Montelukast. Due to its unique chemical structure, its oral bioavailability, clinical efficacy and safety are superior to previous similar drugs, and it is currently the best-selling asthma drug in the world. . In 1998, the Montelukast sodium film-coated tablets of Merck & Co., Ltd. were approved by the US FDA for marketing. So far, the dosage forms of Montelukast sodium that have been on the market include granules, chewable tablets, and orally disintegrating tablets. [0003] Montelukast sodium, its chemical name is [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinoline)vinyl]phenyl-3-[ Sodium 2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetate. The chemical structure is: [0004] [0005] The Chinese patent of CN101365450A disclos...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/47A61K47/36A61K47/26A61P11/06
Inventor 赵志全刘庆晓郝贵周
Owner LUNAN PHARMA GROUP CORPORATION