Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A mesoporous carbon nanoparticle system with targeted drug release and its application

A nanoparticle and mesoporous carbon technology, applied in the field of medicine, can solve the problems of limited quantity of slow/controlled release preparations and high cost of slow and controlled release preparations

Inactive Publication Date: 2016-03-23
SHENYANG PHARMA UNIVERSITY
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

my country began to develop sustained-release and controlled-release preparations in the early 1980s. In the past two decades, due to the complexity of the development of sustained- and controlled-release preparations and the high cost required, the slow / controlled release preparations that have been on the market so far limited quantity

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A mesoporous carbon nanoparticle system with targeted drug release and its application
  • A mesoporous carbon nanoparticle system with targeted drug release and its application
  • A mesoporous carbon nanoparticle system with targeted drug release and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Accurately weigh 0.5g CTAB into a 200mL beaker, add 50mL deionized water and 10mL absolute ethanol respectively, stir magnetically at 500rpm until transparent, then add 20mL anhydrous ether to the above mixed solution, stir magnetically at 800rpm until the emulsion is uniformly dispersed, Then add 0.6mL ammonia water, continue stirring for 2h, then add 2.0mLTEOS dropwise, and continue stirring at room temperature for 12h. Then filter to obtain a white solid, fully wash it with distilled water, dry it fully in an oven at 40°C, and finally, calcine it in a horse-boiler furnace at 500°C for 6 hours to remove the organic components, and pass through a 80-mesh sieve to obtain a white product that is mesoporous dioxide. Silicon nanospheres (SNMs).

Embodiment 2

[0059] Accurately weigh 0.6g CTAB into a 200mL beaker, add 60mL deionized water and 20mL absolute ethanol respectively, stir magnetically at 600rpm until transparent, then add 20mL anhydrous ether to the above mixed solution, stir magnetically at 900rpm until the emulsion is uniformly dispersed, Then add 0.8mL ammonia water, continue stirring for 4h, then add 2.5mLTEOS dropwise, and continue stirring at room temperature for 18h. Then filter to obtain a white solid, wash it thoroughly with distilled water, dry it fully in a 60°C oven, and finally, calcine it in a 600°C horse-boiling furnace for 12 hours to remove the organic components, and pass through a 100-mesh sieve to obtain a white product that is mesoporous dioxide Silicon nanospheres (SNMs).

Embodiment 3

[0061] Accurately weigh 0.7g CTAB into a 200mL beaker, add 80mL deionized water and 20mL absolute ethanol respectively, stir magnetically at 800rpm until transparent, then add 20mL anhydrous ether to the above mixed solution, stir magnetically at 900rpm until the emulsion is evenly dispersed, Then add 0.8mL ammonia water, continue stirring for 4h, then add 2.5mLTEOS dropwise, and continue stirring at room temperature for 18h. Then filter to obtain a white solid, wash it thoroughly with distilled water, dry it fully in a 60°C oven, and finally, calcine it in a 600°C horse-boiling furnace for 12 hours to remove the organic components, and pass through a 100-mesh sieve to obtain a white product that is mesoporous dioxide Silicon nanospheres (SNMs).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
specific surface areaaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of medicine, and relates to a gastrointestinal adhesion-promoting drug delivery system of folic acid-polyethyleneimine modified carbon nanoparticles mediated by folic acid receptors. The carbon nanoparticles modified by folic acid-polyethyleneimine are first prepared by the hard template method using spherical mesoporous silicon as a template to prepare homogeneous mesoporous carbon spheres, and then add carboxyl groups to the homogeneous mesoporous carbon spheres by wet oxidation, and then utilize Simple electrostatic polymerization modified folic acid-polyethyleneimine complex on the surface of carboxylated carbon spheres to obtain folic acid-polyethyleneimine modified carbon nanoparticles. The folic acid-polyethyleneimine complex is prepared by the classic DCC-NHS amide reaction. The invention uses uniform mesoporous carbon spheres as a carrier and folic acid as a targeting molecule to realize drug adhesion and absorption promotion in the gastrointestinal tract. The invention can improve the dissolution rate of the poorly water-soluble drug, increase the adhesion time, promote the transmembrane transport of the drug, improve the bioavailability of the drug, and has broad application prospects in the field of oral administration.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a mesoporous carbon nanoparticle system with targeted drug release and its application, in particular to the gastrointestinal function of carbon nanoparticles modified by folic acid-polyethyleneimine mediated by folic acid receptors. Tract adhesion and absorption-enhancing drug delivery system and its preparation. Background technique [0002] As we all know, oral administration has become the most widely used administration method because of its convenience and easy acceptance by patients, and it is also the preferred administration route for most drugs. According to statistics, in the United States Pharmacopoeia, which contains the most drugs, more than 1 / 3 of the drugs are listed as poorly soluble drugs; in innovative drug research, about 40% of the drugs are poorly soluble drugs; active substances obtained from high-throughput screening also have About 40% of the drugs are po...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/32A61K47/04B82Y5/00
Inventor 王思玲姜同英万龙
Owner SHENYANG PHARMA UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com