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A kind of elastic polyurethane antibacterial material and preparation method thereof

A technology of elastic polyurethane and antibacterial materials, which is applied in the direction of pharmaceutical formulations and medical preparations of non-active ingredients, etc., can solve the problems of affecting the physical and mechanical properties of polymer materials, and the loss of use value of materials, so that the use value is not affected, good Effects of physical and mechanical properties, good biocompatibility

Active Publication Date: 2022-04-08
浙江德美博士达高分子材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, traditional polymers generally achieve ROS-responsive drug release through the breakage of polymer chain segments, which seriously affects the physical and mechanical properties of polymer materials. If the original physical and mechanical properties of the polymer are relatively ordinary, then the response After the material will lose its use value

Method used

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  • A kind of elastic polyurethane antibacterial material and preparation method thereof

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Effect test

Embodiment 1

[0024] A preparation method of elastic polyurethane antibacterial material, comprising the following steps:

[0025] 1) Preparation of modified polyol

[0026] 15 parts by weight of tartaric acid and 150 parts by weight of polyethylene glycol with a molecular weight of 200-600 were added to a four-necked round-bottomed flask, followed by 3 parts of catalyst 4-dimethylaminopyridine, and then the reactants were kept at 60 °C for The reaction was carried out for 1.5 hours; then the temperature was raised to 120°C at a rate of 2°C per minute, and the temperature was maintained for 1 hour; finally, the reaction mixture was cooled to 20°C to obtain the modified polyol;

[0027] 2) Preparation of polyurethane

[0028] Add 3 parts by weight of carvone and 2 parts by weight of emulsifier N-methyldiethanolamine to 1) 30 parts by weight of modified polyols prepared, stir at 110° C. for 1.5 hours; then feed nitrogen into the reaction vessel Cool to 30 ° C; add 55 parts by weight of hexa...

Embodiment 2

[0030] A preparation method of elastic polyurethane antibacterial material, comprising the following steps:

[0031] 1) Preparation of modified polyol

[0032] Add 20 parts by weight of tartaric acid and 200 parts by weight of polypropylene glycol with a molecular weight of 400-2000 to a four-necked round-bottomed flask, then add 5 parts by weight of catalyst 4-dimethylaminopyridine, and then continue the reaction at 70 ° C. 2.5 hours; then increase the temperature to 130°C at a rate of 3°C per minute, and keep the temperature for 2 hours; finally, cool the reaction mixture to 30°C to obtain the modified polyol;

[0033] 2) Preparation of polyurethane

[0034] Add 5 parts by weight of cinnamaldehyde and 4 parts by weight of emulsifier N-methyldiethanolamine to 1) 40 parts by weight of the prepared modified polyol, and stir at 120 ° C for 2.5 hours; then feed nitrogen into the reaction vessel for cooling to 40 ° C; then add 60 parts by weight of cycloaliphatic diisocyanate, a...

Embodiment 3

[0036] A preparation method of elastic polyurethane antibacterial material, comprising the following steps:

[0037] 1) Preparation of modified polyol

[0038] In the four-necked round bottom flask, add 25 parts by weight of tartaric acid and 250 parts by weight of polyethylene adipate diol with a molecular weight of 400-1500, then add 6 parts by weight of catalyst 4-dimethylaminopyridine, and then The reactant was continuously reacted at 80°C for 3.5 hours; then the temperature was increased to 135°C at a rate of 4°C per minute, and the temperature was maintained for 3 hours; finally, the reaction mixture was cooled to 40°C to obtain the modified polyol;

[0039] 2) Preparation of polyurethane

[0040]Add 8 parts by weight of citral and 5 parts by weight of emulsifier N-methyldiethanolamine to 1) 45 parts by weight of the prepared modified polyol, and stir at 140 ° C for 4 hours; then feed nitrogen into the reaction vessel for cooling to 50 ° C; then add 65 parts by weight ...

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Abstract

The invention discloses an elastic polyurethane antibacterial material and a preparation method thereof. Firstly, tartaric acid and polypolyol are catalyzed to obtain modified polypolyol, and then antibacterial drugs and emulsifiers are added to the modified polypolyol, and reacted at high temperature for a period of time. Afterwards, nitrogen gas is introduced to lower the temperature, polyvalent isocyanate and chain extender are added to the reactant, and gastrodin is used to end the reaction to obtain an elastic polyurethane antibacterial material. The antibacterial material of the present invention can generate ROS stimulation response in the presence of bacteria, effectively improving the utilization rate of the drug; the present invention provides tartaric acid itself with a large number of active functional groups, which can form a cross-linked network structure, and can be changed by adjusting the ratio of synthetic raw materials The crosslink density of the network structure regulates the drug release rate when the antibacterial material responds. The added gastrodin can improve the mechanical properties and deformation resistance of the polyurethane antibacterial material, so that the polyurethane antibacterial material still has good physical and mechanical properties after the chemical bond is broken during the ROS response release process.

Description

technical field [0001] The invention belongs to the field of polymer materials, and relates to an elastic polyurethane antibacterial material and a preparation method thereof. Background technique [0002] Polyurethane is a material with excellent wear resistance, chemical resistance and easy processing. It can be used in industrial product coating, food packaging, medical auxiliary materials and other fields. In addition, polyurethane can obtain various functions by chemical modification or changing the composition of raw materials. [0003] Traditional polyurethane materials are susceptible to bacterial contamination from the surrounding environment in daily use, and researchers avoid this problem by encapsulating antibacterial agents in the materials. However, this traditional material will continuously release antibacterial agents into the environment, which brings the problem that when there are not many bacteria in the environment, the excessive and sustained release ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/66C08G18/48C08G18/42C08G18/38C08G18/32A61K47/34
CPCC08G18/6677C08G18/6644C08G18/4833C08G18/4825C08G18/4238C08G18/4211C08G18/3868C08G18/3218A61K47/34C08G2230/00
Inventor 杨明华许媛欢赵锦聂琼芳叶如兰
Owner 浙江德美博士达高分子材料有限公司
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