A kind of antithrombotic pharmaceutical composition and application thereof
An antithrombotic and drug technology, which is applied in the field of antithrombotic pharmaceutical compositions, can solve the problem of no bibliographical reports on anticoagulant or antithrombotic biological activities of methyl desacetylphosphorylate, and achieve strong biological activity Effect
Inactive Publication Date: 2016-09-14
THE THIRD PEOPLES HOSPITAL OF QINGDAO
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Problems solved by technology
[0004] By searching domestic and foreign literature, no literature reports have been found on the biological activity of deacetylpyrrolidinate, such as anticoagulant or antithrombotic
Method used
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Embodiment 1
[0015] Embodiment 1: the influence of deacetylpyrrolidinic acid methyl ester on rat inferior vena cava thrombosis
[0016] Take 36 male clean-grade Wistar rats and divide them into 3 groups at random, namely: model control group (normal saline), positive control group (5mg / kg), test group (40mg / kg), 12 in each group. Each group of rats was given the corresponding test substance in the following doses:
[0017] Model control group: 10mL / kg normal saline;
[0018] Positive control group: 5mg / kg aspirin;
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The invention discloses an antithrombotic medicine composition and an application thereof. The antithrombotic medicine composition is prepared from active components and auxiliary materials. The active components comprise desacetyl asperulosidic acid methyl ester. The medicine has strong antithrombotic bioactivity and can be independently used as a medicine for preventing and treating thrombotic diseases.
Description
technical field [0001] The invention belongs to the technical field of natural medicines, and in particular relates to an antithrombotic pharmaceutical composition and its application. Background technique [0002] Cerebrovascular disease is a high-incidence disease that has seriously endangered public health, especially the health of the elderly. At present, the death rate caused by cardiovascular and cerebrovascular diseases in the world has ranked first in the death rate of other diseases. The formation of thrombus can lead to various diseases, such as pulmonary thromboembolism, atherosclerosis, coronary heart disease, cerebrovascular disease, deep vein embolism after surgery or trauma. [0003] Gardenia jasminoides Ellis (Gardenia jasminoides Ellis) is the dried and mature fruit of Gardenia jasminoides of Rubiaceae. It is cold in nature and bitter in taste. It is a commonly used heat-clearing traditional Chinese medicine. The main and active ingredients of gardenia are...
Claims
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IPC IPC(8): A61K31/7048A61P7/02
Inventor 杨成梅顾国岳
Owner THE THIRD PEOPLES HOSPITAL OF QINGDAO