Method for preparing methylene blue-containing silica/octacalcium phosphate particles

Abstract

The invention provides a method for preparing methylene blue-containing silica / octacalcium phosphate particles and belongs to the technical field of production of chemical raw materials. The method comprises the following steps: sequentially adding ammonia water, methylene blue and ethyl orthosilicate into a solution containing water and ethanol, stirring for 4 hours, centrifuging, performing ethanol washing, and preparing a methylene blue-containing silica colloidal solution by using ethanol; adding citric acid, calcium nitrate and diammonium hydrogen phosphate into the solution containing water and ethanol, regulating the pH value of the solution to 9 by using ammonia water, adding polyethylene glycol, stirring for an hour, pouring the methylene blue-containing silica colloidal solution, stirring for 3 hours, centrifuging, washing and drying to obtain the methylene blue-containing silica / octacalcium phosphate particles. The method is simple in process, is low in raw material price and is easy for industrial production. The particles prepared by the method are high in biocompatibility and easy to degrade. The methylene blue is released into the solution from the interior of the particles in a monomer molecule form, and the release behavior can be conveniently regulated and controlled.

Description

technical field [0001] The invention provides a method for preparing silicon dioxide / octacalcium phosphate particles containing methylene blue, which belongs to the technical field of chemical raw material production. Background technique [0002] Methylene blue is widely used in different fields. It is mainly used for fluorescent tracing after staining of biological cells and for sterilization by generating singlet oxygen molecules after photosensitive oxidation reactions. It is also used for the treatment of diseases such as malaria and urinary tract infections. The aggregation of tau protein in patients with Alzheimer's disease has a significant inhibitory effect. In aqueous solution, methylene blue molecules often exist in the form of monomers, dimers, and polymers, and the aggregation shape of molecules has a significant impact on its fluorescence properties, photosensitive oxidation reactions, and redox properties. When the fluorescent signal is used for tracing, the ...

AI Technical Summary

Problems solved by technology

If the methylene blue molecules are mainly released from the particles into the solution in the form of monomers, the efficiency of the reduction and absorption of the methylene blue molecules will be greatly improved, and the therapeutic effect of the methylene blue can be guaranteed. However, so far, no relevant research has been seen. to report

Images