Method for preparing methylene blue-containing silica/octacalcium phosphate particles

A technology of methylene blue and silicon dioxide, which is applied in medical preparations containing active ingredients, medical preparations without active ingredients, pharmaceutical formulas, etc., can solve problems such as no reports, and achieve prolonged residence time and release time. , good biocompatibility

Inactive Publication Date: 2014-09-03
SHANDONG UNIV OF TECH
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the methylene blue molecules are mainly released from the particles into the solution in the form of monomers, the efficiency of the reduction and absorption of the methyle

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing methylene blue-containing silica/octacalcium phosphate particles
  • Method for preparing methylene blue-containing silica/octacalcium phosphate particles
  • Method for preparing methylene blue-containing silica/octacalcium phosphate particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) In a solution containing 92 milliliters of ethanol and 17.2 milliliters of water, add 2.48 milliliters of ammonia and stir evenly before adding methylene blue. After stirring for 10 minutes, add 3.44 milliliters of tetraethyl orthosilicate to make the concentration of methylene blue 2.32 millimoles Per liter, centrifuge after stirring for 4 hours and wash the sediment with ethanol, then use ethanol to prepare a colloidal solution of silica containing methylene blue;

[0024] (2) In a solution containing 138.3 milliliters of water and 46.1 milliliters of ethanol, sequentially add citric acid, calcium nitrate and diammonium hydrogen phosphate to make the concentrations respectively 0.116 millimoles per liter, 0.0567 millimoles per liter and 0.0349 millimoles per liter After the solution is completely dissolved, adjust the pH value of the solution to 9 with ammonia water, then add polyethylene glycol with a molecular weight of 2000 to make the concentration 2.5 micromol...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a method for preparing methylene blue-containing silica/octacalcium phosphate particles and belongs to the technical field of production of chemical raw materials. The method comprises the following steps: sequentially adding ammonia water, methylene blue and ethyl orthosilicate into a solution containing water and ethanol, stirring for 4 hours, centrifuging, performing ethanol washing, and preparing a methylene blue-containing silica colloidal solution by using ethanol; adding citric acid, calcium nitrate and diammonium hydrogen phosphate into the solution containing water and ethanol, regulating the pH value of the solution to 9 by using ammonia water, adding polyethylene glycol, stirring for an hour, pouring the methylene blue-containing silica colloidal solution, stirring for 3 hours, centrifuging, washing and drying to obtain the methylene blue-containing silica/octacalcium phosphate particles. The method is simple in process, is low in raw material price and is easy for industrial production. The particles prepared by the method are high in biocompatibility and easy to degrade. The methylene blue is released into the solution from the interior of the particles in a monomer molecule form, and the release behavior can be conveniently regulated and controlled.

Description

technical field [0001] The invention provides a method for preparing silicon dioxide / octacalcium phosphate particles containing methylene blue, which belongs to the technical field of chemical raw material production. Background technique [0002] Methylene blue is widely used in different fields. It is mainly used for fluorescent tracing after staining of biological cells and for sterilization by generating singlet oxygen molecules after photosensitive oxidation reactions. It is also used for the treatment of diseases such as malaria and urinary tract infections. The aggregation of tau protein in patients with Alzheimer's disease has a significant inhibitory effect. In aqueous solution, methylene blue molecules often exist in the form of monomers, dimers, and polymers, and the aggregation shape of molecules has a significant impact on its fluorescence properties, photosensitive oxidation reactions, and redox properties. When the fluorescent signal is used for tracing, the ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/16A61K31/5415A61K47/04A61K47/02A61K47/34A61P31/04A61P33/06A61P13/00A61P25/28
Inventor 李成峰范琦王燕云李亚东葛筱璐
Owner SHANDONG UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap