Method for preparing methylene blue-containing silica/octacalcium phosphate particles
A technology of methylene blue and silicon dioxide, which is applied in medical preparations containing active ingredients, medical preparations without active ingredients, pharmaceutical formulas, etc., can solve problems such as no reports, and achieve prolonged residence time and release time. , good biocompatibility
A technology of methylene blue and silicon dioxide, which is applied in medical preparations containing active ingredients, medical preparations without active ingredients, pharmaceutical formulas, etc., can solve problems such as no reports, and achieve prolonged residence time and release time. , good biocompatibility
CN104013579AInactive Publication Date: 2014-09-03SHANDONG UNIV OF TECH
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Embodiment 1
[0023] (1) In a solution containing 92 milliliters of ethanol and 17.2 milliliters of water, add 2.48 milliliters of ammonia and stir evenly before adding methylene blue. After stirring for 10 minutes, add 3.44 milliliters of tetraethyl orthosilicate to make the concentration of methylene blue 2.32 millimoles Per liter, centrifuge after stirring for 4 hours and wash the sediment with ethanol, then use ethanol to prepare a colloidal solution of silica containing methylene blue;
[0024] (2) In a solution containing 138.3 milliliters of water and 46.1 milliliters of ethanol, sequentially add citric acid, calcium nitrate and diammonium hydrogen phosphate to make the concentrations respectively 0.116 millimoles per liter, 0.0567 millimoles per liter and 0.0349 millimoles per liter After the solution is completely dissolved, adjust the pH value of the solution to 9 with ammonia water, then add polyethylene glycol with a molecular weight of 2000 to make the concentration 2.5 micromol...
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The invention provides a method for preparing methylene blue-containing silica / octacalcium phosphate particles and belongs to the technical field of production of chemical raw materials. The method comprises the following steps: sequentially adding ammonia water, methylene blue and ethyl orthosilicate into a solution containing water and ethanol, stirring for 4 hours, centrifuging, performing ethanol washing, and preparing a methylene blue-containing silica colloidal solution by using ethanol; adding citric acid, calcium nitrate and diammonium hydrogen phosphate into the solution containing water and ethanol, regulating the pH value of the solution to 9 by using ammonia water, adding polyethylene glycol, stirring for an hour, pouring the methylene blue-containing silica colloidal solution, stirring for 3 hours, centrifuging, washing and drying to obtain the methylene blue-containing silica / octacalcium phosphate particles. The method is simple in process, is low in raw material price and is easy for industrial production. The particles prepared by the method are high in biocompatibility and easy to degrade. The methylene blue is released into the solution from the interior of the particles in a monomer molecule form, and the release behavior can be conveniently regulated and controlled.
Description
technical field [0001] The invention provides a method for preparing silicon dioxide / octacalcium phosphate particles containing methylene blue, which belongs to the technical field of chemical raw material production. Background technique [0002] Methylene blue is widely used in different fields. It is mainly used for fluorescent tracing after staining of biological cells and for sterilization by generating singlet oxygen molecules after photosensitive oxidation reactions. It is also used for the treatment of diseases such as malaria and urinary tract infections. The aggregation of tau protein in patients with Alzheimer's disease has a significant inhibitory effect. In aqueous solution, methylene blue molecules often exist in the form of monomers, dimers, and polymers, and the aggregation shape of molecules has a significant impact on its fluorescence properties, photosensitive oxidation reactions, and redox properties. When the fluorescent signal is used for tracing, the ...
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Patent Timeline
03 Sep 2014
Publication
CN104013579A
- IPC
- A61K9/16; A61K31/5415; A61K47/04; A61K47/02; A61K47/34; A61P31/04; A61P33/06; A61P13/00; A61P25/28
- Inventors
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