Application of tetrahydroberberine in preparation of drugs used for treating senile dementia

A technology for tetrahydroberberine and senile dementia, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc. Apoptosis and the effect of improving the ability to resist oxidative damage

Inactive Publication Date: 2014-09-10
BEIJING YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prior art has carried out many pharmacological activity studies on tetrahydroberberine, mainly analgesic, sedative and stable effects; cardiovascular and cerebrovascular effects, such as anti-arrhythmia, anti-hypertension, anti-platelet aggregation, myocardial ischemia protection, cerebral Ischemic protection; anti-allergic effect; dopamine receptor blocking effect; M-choline receptor affinity effect, etc. Currently, there is no anti-senile dementia effect of this drug

Method used

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  • Application of tetrahydroberberine in preparation of drugs used for treating senile dementia
  • Application of tetrahydroberberine in preparation of drugs used for treating senile dementia
  • Application of tetrahydroberberine in preparation of drugs used for treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0198] Embodiment 1: preparation of tetrahydroberberine tablet

[0199] Weigh 90g of tetrahydroberberine raw material, add 30g of microcrystalline cellulose, 90g of lactose, mix thoroughly, add 30ml of 5% povidone K30 aqueous solution, add 10ml of water, fully stir, mix evenly, and granulate with a 24 mesh sieve , dried at 70°C, granulated, added with 1% magnesium stearate, mixed evenly, compressed to make 1000 tablets.

Embodiment 2

[0200] Embodiment 2: preparation of tetrahydroberberine capsules

[0201] Weigh 90g of tetrahydroberberine raw material, add 20g of microcrystalline cellulose, add 10g of crospovidone, 130g of lactose, mix well, add 30ml of 5% povidone K30 aqueous solution, add 15ml of water, fully stir, mix Evenly, granulate with a 24-mesh sieve, dry at 70°C, granulate, add 1% magnesium stearate, mix evenly, and pack into capsules to obtain 1000 capsules.

Embodiment 3

[0202] Embodiment 3: tetrahydroberberine drop pill preparation

[0203] Weigh 1000g of polyethanol 6000, melt in a water bath at 70°C, add 30g of tetrahydroberberine raw material, stir while adding, fully stir after adding, drop into pills, and make 3000 drop pills.

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PUM

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Abstract

The invention discloses application of tetrahydroberberine in preparation of drugs used for treating senile dementia, which belongs to novel application of drugs. The dosage form of tetrahydroberberine may be a capsule, a tablet, a granule, a spraying agent, an injection or a pill, and tetrahydroberberine exerts a good curative effect on the senile dementia.

Description

technical field [0001] The invention belongs to the new application of medicine, in particular to the new application of tetrahydroberberine. Background technique [0002] Alzheimer's disease is a disease of the central nervous system. Its onset is insidious and its course is chronic and progressive. It is the most common type of senile dementia. The main manifestations are neuropsychiatric symptoms such as progressive memory impairment, cognitive dysfunction, personality changes, and language barriers, which seriously affect social interaction, work, and daily life. The etiology and pathogenesis of AD have not yet been elucidated, and the characteristic pathological changes include β-amyloid (Aβ 25-35 ) deposition of extracellular senile plaques and intracellular neurofibrillary tangles formed by hyperphosphorylation of Tau protein, as well as neuron loss with gliosis, etc. The general therapeutic drugs mainly include: (1) Cholinesterase inhibitors: increase the level of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P25/28A61P39/06
Inventor 梁俊清姚兵吕子明侯斌王志鑫徐明远张梓倩王娜李文燕
Owner BEIJING YILING PHARMA
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