A kind of astaxanthin nanoemulsion preparation and preparation method thereof
A technology of astaxanthin and emulsion preparation, which is applied in the directions of antitoxins, pharmaceutical formulations, emulsion delivery, etc., can solve the problems of unstable biological macromolecules, unstable preparations, and weak protective effect of astaxanthin.
Active Publication Date: 2016-06-29
QINGDAO YOUDO BIOENG
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However, the protective effect on astaxanthin after biomacromolecule chelation is not very good, because of the porosity of the biomacromolecule structure, and secondly, the biomacromolecule is unstable during storage; ethanol is easy to volatilize, which will cause the preparation to be unstable, and the shrimp The protective effect of penicillin is not very strong
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[0018] Such as figure 1 As shown, the present invention provides a preparation method of astaxanthin nanoemulsion preparation, which is characterized in that it includes the step: S1, mixing astaxanthin oil with oil phase to form the first mixed oil phase, and the weight of the astaxanthin oil accounts for Less than 40% of the weight of the first mixed oil phase; S2, adding a surfactant to the first mixed oil phase and mixing uniformly to form a second mixed oil phase, the weight ratio of the surfactant to the first mixed oil phase is 2:3 ; S3, adding the water phase to the second mixed oil phase and stirring evenly to obtain an oil-in-water emulsion, wherein the water phase accounts for 90% of the total weight.
[0019] When the ratio of the first oil phase, surfactant, and water phase is fixed, the particle size of the prepared emulsion is constant. If the ratio of astaxanthin oil is increased, the particle size will be changed, so the content of astaxanthin oil is 40%. Bel...
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The invention provides an astaxanthin nano-emulsion preparation and a preparation method thereof, which is characterized in that it comprises the step of: S1, mixing astaxanthin oil with an oil phase to form a first mixed oil phase, and the weight of the astaxanthin oil accounts for the first mixed oil phase. Below 40% of the weight of a mixed oil phase; S2, adding a surfactant to the first mixed oil phase and mixing uniformly to form a second mixed oil phase, the weight ratio of the surfactant to the first mixed oil phase is 2: 3; S3, adding the water phase into the second mixed oil phase and stirring evenly, wherein the water phase accounts for 90% of the total weight. The astaxanthin nano-emulsion preparation and its preparation method provided by the present invention do not require equipment such as a high-pressure homogenizer and an ultrasonic breaker, and utilize the characteristics of the hydrophobicity of the organic phase of the emulsion to wrap the hydrophobic astaxanthin oil in the oil phase, The use of organic solvents such as acetone is avoided; at the same time, the astaxanthin is embedded in the nanoemulsion by using the low-energy nanoemulsion method, which improves the stability of the astaxanthin.
Description
technical field [0001] The invention relates to a preparation method of a nanoemulsion carrier used for hydrophobic substance astaxanthin, in particular to an astaxanthin nanoemulsion preparation and a preparation method thereof. Background technique [0002] Astaxanthin is a ketone carotenoid with the molecular formula C 40 h 52 o 4 , The relative molecular weight is 596.86. Astaxanthin has a strong antioxidant capacity, which is 550 times that of vitamin E and 10 times that of β-carotene. Many products of astaxanthin have been proved to be safe and effective, so they have a wide range of applications in medicine, food and cosmetics. market and huge potential for development. [0003] However, astaxanthin is a hydrophobic substance, which is easily oxidized in the environment and is not resistant to high temperature and pressure, so the application of astaxanthin is limited. In the prior art, when preparing astaxanthin carriers, astaxanthin oil is generally dissolved i...
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IPC IPC(8): A61K9/107A61K31/122A61P39/06
Inventor 陈风平于钰丁松
Owner QINGDAO YOUDO BIOENG