Method for acquiring characterization parameters of coronary disease

A technology for characterizing parameters and obtaining methods, applied in the medical field, can solve the problems of insufficient in-depth research on comprehensive genetic analysis of susceptibility to coronary heart disease, lack of accuracy, systematicness and integrity of effectiveness, etc.

Inactive Publication Date: 2014-09-17
西安时代基因健康科技股份有限公司
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Problems solved by technology

At the same time, there are not many in-depth studies on the comprehensive genetic analysis of susceptibility to coronary heart disease, and the early warning or intervention products related to the transformation

Method used

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  • Method for acquiring characterization parameters of coronary disease
  • Method for acquiring characterization parameters of coronary disease

Examples

Experimental program
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Example Embodiment

[0042] Example one

[0043] 1) Establish a database of coronary heart disease susceptibility genes:

[0044] 1.1) The gene names associated with coronary heart disease were initially found on the GWAS website;

[0045] 1.2) In the Pubmed database of NCBI, screen out susceptibility genes related to coronary heart disease in Chinese;

[0046] 1.3) Find the results of the association analysis related to the Chinese population, and determine the susceptibility gene locus obtained in step 1.2); the conditions for the association analysis related to the Chinese population are: the sample is a large sample population and the source of the sample is The Chinese population has an or value greater than 1, and 95% CI does not contain 1, and is statistically significant; the large sample population includes at least 200 people.

[0047] 1.4) Verify the location of the susceptible gene determined in step 1.3) in the SNP database of NCBI;

[0048] 1.5) Compile a susceptible gene corpus; the susceptib...

Example Embodiment

[0067] Example two

[0068] 1. The client submits an application to a medical institution or a physical examination institution, and fills in an application form for genome testing and genetic analysis and a health questionnaire;

[0069] 2. Collection and preservation of blood samples;

[0070] 3. The sample is sent to the genetic testing laboratory;

[0071] 4. Perform genetic testing according to the susceptible gene testing combination sites in Table 1, and feed back the original data of genome testing in time;

[0072] 5. Disease genetic risk analysis and in-depth genetic analysis of high-risk diseases;

[0073] 6. Comprehensive assessment of internal and external causes of high-risk diseases;

[0074] 7. Genome-oriented personalized health management recommendations;

[0075] Among them, step 5, step 6 and step 7 are implemented through an automated platform for genetic analysis of complex diseases. Professional genetic analysts will complete steps 5, 6 and 7 based on the results of...

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Abstract

The invention discloses a method for acquiring characterization parameters of a coronary disease. The method comprises the following steps: 1) establishing a coronary disease susceptibility gene database; 2), establishing a characterization parameter analysis platform of an individual coronary disease according to the coronary disease susceptibility gene database established in the step 1); 3) analyzing the characterization parameters of the individual coronary disease on the basis of the analysis platform established in the step 2); 4) outputting the characterization parameters of the individual coronary disease. The method disclosed by the invention is capable of accurately acquiring characterization information in time and laying a foundation for sequential treatment work.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a method for acquiring parameters, in particular to a method for acquiring characteristic parameters of coronary heart disease. Background technique [0002] Coronary atherosclerotic heart disease refers to the heart disease caused by coronary atherosclerotic lesions leading to stenosis or blockage of blood vessel lumen, resulting in myocardial ischemia, hypoxia or necrosis, collectively referred to as coronary heart disease (coronary heart disease), referred to as coronary heart disease, also known as ischemic heart disease (ischemic heart disease). Coronary atherosclerotic heart disease is the most common type of organ lesions caused by atherosclerosis, and it is also a common disease that seriously endangers human health. [0003] Coronary heart disease is relatively common in developed countries in Europe and the United States. About 500,000 people die from this disease in the...

Claims

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Application Information

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IPC IPC(8): G06F19/00G06F17/30
Inventor 杨进孟涛赵锦荣赵东董靖张伟许嘉玲钱美睿牛彬彬徐博特贺红娟陈尔飞
Owner 西安时代基因健康科技股份有限公司
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