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A kind of bioelectrode and preparation method thereof

A bio-electrode and electrode wire technology, which is applied in the direction of material analysis, instruments, and measuring devices by electromagnetic means, to achieve the effects of small size, high mechanical strength and high reliability

Inactive Publication Date: 2017-03-01
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the above defects or improvement needs of the prior art, the present invention provides a bioelectrode whose purpose is to solve the problem by integrating multiple working electrode lines, reference electrode lines and counter electrode lines on a small-sized bioelectrode. The technical problem that the existing technology cannot realize simultaneous in vivo detection of multiple biological signals at the same point

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  • A kind of bioelectrode and preparation method thereof
  • A kind of bioelectrode and preparation method thereof
  • A kind of bioelectrode and preparation method thereof

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preparation example Construction

[0050] The preparation method of bioelectrode provided by the invention comprises the following steps:

[0051](1) Electrode wire insulation: Dissolve insulating wax in a volatile organic solvent to obtain an insulating liquid, apply the insulating liquid evenly on the side surface of the electrode wire, and wait for the organic solvent to volatilize to obtain an electrode wire insulated on the side surface; preferably The insulating liquid is a solution mixed with apizon wax and organic solvent dichloromethane at a ratio of 1:1 (w / v). Apizon wax has good insulation performance and is evenly distributed without agglomeration. In the bioelectrode provided by the present invention.

[0052] (2) Integrated fixation of electrode wires: Insert the electrode wires with insulated side surfaces obtained in step (1) into the insulating casing at the same time, pour the resin into the casing, and after curing, polish the tip of the casing smooth to obtain the bioelectrode.

[0053] Pre...

Embodiment 1

[0059] A bioelectrode, such as figure 1 As shown, it includes an insulating shell and electrode wires. The electrode wires include three working electrode wires, two reference electrode wires and a counter electrode wire. In the insulating shell, the tip of the shell is opened, and the opening diameter of the tip is 1mm. The detection end of the electrode wire contacts the biological sample to be tested through the opening, and the insulating shell is made of polypropylene material.

[0060] The three working electrode lines of the biological electrode are respectively the first working electrode line, the second working electrode line and the third working electrode line; wherein:

[0061] The first working electrode wire, used for current measurement, is a platinum wire with a diameter of 50 μm and a length of 4 cm;

[0062] The second working electrode wire, used for current measurement, is a platinum wire with a diameter of 50 μm and a length of 4 cm;

[0063] The third ...

Embodiment 2

[0074] A bioelectrode, such as figure 2 As shown, it includes an insulating shell and electrode wires. The electrode wires include three working electrode wires, two reference electrode wires and a counter electrode wire. In the insulating shell, the tip of the shell is opened, and the opening diameter of the tip is 1mm. The detection end of the electrode wire contacts the biological sample to be tested through the opening, and the insulating shell is made of polypropylene material.

[0075] The three working electrode lines of the biological electrode are respectively the first working electrode line, the second working electrode line and the third working electrode line; wherein:

[0076] The first working electrode wire is used for current measurement to obtain the concentration of hydrogen peroxide, which is a platinum wire with a diameter of 50 μm and a length of 4 cm;

[0077] The second working electrode wire is used for current measurement to obtain the concentration...

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Abstract

The invention discloses a bioelectrode and a preparation method thereof. The bioelectrode comprises an insulating shell and electrode wires, wherein the electrode wires include multiple work electrode wires, and one or more reference electrode wires and counter electrode wires; the side surface of each electrode wire is coated with insulating wax; resin is encapsulated in the insulating shell; the tip end of the shell is provided with an opening with the diameter of 0.4mm to 2mm; the detection end of each electrode wire is in contact with a to-be-detected biological sample through the opening. The preparation method comprises the following steps: (1) dissolving the insulating wax in a volatile organic solvent to obtain an insulating liquid, evenly coating the side surface of each electrode wire with the insulating liquid and volatilizing the organic solvent; and (2) inserting the electrode wires into the insulating shell simultaneously, pouring the resin into the shell, performing curing, and polishing the tip end of the shell to be smooth. The bioelectrode is capable of detecting various signals of a carrier at the same time and at the same site, has the good mechanical performance and is suitable to detection on a living body, and the method has the strong adaptability.

Description

technical field [0001] The invention belongs to the field of biological detection, and more specifically relates to a biological electrode and a preparation method thereof. Background technique [0002] Sensing and detection technology has played an important role in the field of bioanalysis. At present, the use of electrochemical sensors for in vitro detection and analysis of biomolecules is relatively mature, and the use of electrochemical sensors for in vivo detection of biologically active substances has also attracted more and more researchers' attention. At present, there have been many studies using electrochemical methods to detect active molecules in organisms, such as using carbon fiber electrodes to detect changes in the hydrogen peroxide content of plants under water stress [Ren Qiong-qiong, etal. Biosensors and bioelectronics, 2013, 50: 318-324], using platinum microelectrodes to detect NO content in mouse kidneys [Youngmi Lee, et al.Analytical chemistry, 2007,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/327
Inventor 赵元弟陈威任琼琼
Owner HUAZHONG UNIV OF SCI & TECH