Method for constructing rat high-triglyceride acute pancreatitis model

A technology for acute pancreatitis and high triglycerides, which is applied in the field of animal model construction of diseases, and can solve problems such as inability to simulate high triglycerides pancreatitis
CN104146993AInactive Publication Date: 2014-11-19戴睿武
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
戴睿武
Publication Date
2014-11-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for constructing a rat high-triglyceride acute pancreatitis model, and solves the problem that high-triglyceride acute pancreatitis cannot be simulated clinically in the prior art. The method comprises the following steps: (1) rearing a male SD rat to have hyperlipemia; (2) injecting free fatty acid into the artery of the male SD rat, and inducing the acute pancreatitis through free fatty acid. According to the method, the occurrence of the high-triglyceride acute pancreatitis can be excellently simulated, and a good foundation is laid for research on the high-triglyceride acute pancreatitis.
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Description

technical field

[0001] The invention relates to a method for constructing an animal model of a disease, in particular to a method for constructing a rat high triglyceride type acute pancreatitis model. Background technique

[0002] At present, the well-known method of establishing rat experimental acute pancreatitis model is to inject 5% sodium taurocholate retrogradely into the pancreaticobiliary duct to establish rat SAP model. This method is to retrogradely inject 5% taurocholate into the pancreaticobiliary duct of rats. Sodium 1.0ml / kg, injection speed 0.1ml / min, injection lasts 10 minutes. This method only simulates clinical pancreatitis caused by pancreatic duct obstruction and bile reflux, but cannot simulate the onset of high triglyceride pancreatitis. Contents of the invention

[0003] The purpose of the present invention is to provide a method for constructing a rat model of hypertriglyceride acute pancreatitis, so as to solve the problem that the prior art cann...

Claims

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