Cinnabar nerve-calming tablet and preparation method thereof
A technology of Anshen Tablet and Cinnabar, applied in the field of Cinnabar Anshen Tablet and its preparation, can solve the problems of low curative effect, unsatisfactory curative effect, slow disintegration and the like
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Embodiment 1
[0027] Take Changshan 150g, Cinnabar 100g, Coptidis 150g, Rehmannia glutinosa 100g, grind into 60 mesh coarse powder, use carbon dioxide supercritical extraction method to extract, extraction pressure 20Mpa, extraction temperature 20°C, separator pressure 10Mpa, separator temperature 40°C, separation time For 2 hours, the carbon dioxide flow rate is 20L per hour to obtain the extract; take the extract and dry it under reduced pressure at 60°C to obtain a dry paste; add 80g of soybean lecithin to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste with a particle size of 200-300nm powder; take mixed dry cream powder, microcrystalline cellulose 35g, crospovidone 35g, croscarmellose sodium 35g, sodium lauryl sulfate 25g, micropowder silica gel 15g, sodium chloride 5g, mannitol 4g, 4g of lactose, mixed evenly, wet granulated with 50% ethanol, dried at 60°C, added 7g of sodium carboxymethyl starch, 1g of magnesium stearate, granulated, presse...
specific Embodiment 2
[0029] Take Changshan 150g, Cinnabar 100g, Coptidis 150g, Rehmannia glutinosa 100g, grind into 60 mesh coarse powder, use carbon dioxide supercritical extraction method, extraction pressure 40Mpa, extraction temperature 40°C, separator pressure 20Mpa, separator temperature 60°C, separation time For 4 hours, the carbon dioxide flow rate is 40L per hour to obtain the extract; take the extract and dry it under reduced pressure at 80°C to obtain a dry paste; add 120g of soybean lecithin to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste with a particle size of 200-300nm powder; take mixed dry cream powder, microcrystalline cellulose 45g, cross-linked polyvinylpyrrolidone 45g, croscarmellose sodium 45g, sodium lauryl sulfate 35g, micropowder silica gel 25g, sodium chloride 15g, mannitol 6g of lactose, 6g of lactose, mixed evenly, wet granulated with 70% ethanol, dried at 80°C, added 9g of sodium carboxymethyl starch, 3g of magnesium stear...
Embodiment 3
[0031] Take Changshan 150g, Cinnabar 100g, Coptidis 150g, Rehmannia glutinosa 100g, grind into 60 mesh coarse powder, use carbon dioxide supercritical extraction method to extract, extraction pressure 30Mpa, extraction temperature 30°C, separator pressure 15Mpa, separator temperature 50°C, separation time For 3 hours, the carbon dioxide flow rate is 30L per hour to obtain the extract; take the extract and dry it under reduced pressure at 70°C to obtain a dry paste; add 100g of soybean lecithin to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste with a particle size of 200-300nm powder; take mixed dry paste powder, microcrystalline cellulose 40g, cross-linked polyvinylpyrrolidone 40g, croscarmellose sodium 40g, sodium lauryl sulfate 30g, micropowder silica gel 20g, sodium chloride 20g, mannitol 5g of lactose, 5g of lactose, mixed evenly, wet granulated with 60% ethanol, dried at 70°C, added with 8g of sodium carboxymethyl starch, 2g of...
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