Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method for blending type contrast agent with T1 and T2 contrast functions

A technology of contrast agent and function, which is applied in the field of preparation of blended contrast agent, which can solve the problems of brightening the enhanced picture and not being able to achieve image signals at the same time

Active Publication Date: 2014-12-03
ZHANGJIAGANG IND TECH RES INST CO LTD DALIAN INST OF CHEM PHYSICS CHINESE ACADEMY OF SCI +1
View PDF3 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, under different scanning pulse sequences, for the same contrast agent, it is not possible to achieve a good image signal enhancement effect of brightening the image and darkening the image at the same time

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method for blending type contrast agent with T1 and T2 contrast functions
  • Preparation method for blending type contrast agent with T1 and T2 contrast functions
  • Preparation method for blending type contrast agent with T1 and T2 contrast functions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Dissolve 0.718g of F127 in 25mL of secondary deionized water, and sonicate at 50°C for 30min to fully dissolve it.

[0027] 2. Slowly add 0.189g of terephthalic acid, 0.160g of gadolinium trichloride and 0.041g of ferric chloride hexahydrate into the above solution, and continue to sonicate until a uniform and transparent solution is obtained.

[0028] 3. Put the transparent solution obtained in 2 into the hydrothermal reaction kettle, and react at 150°C for 24h.

[0029] 4. After the reaction, centrifuge the reaction solution to remove the secondary deionized water reaction solution.

[0030] 5. The crude product was then washed twice with N,N-dimethylformamide to remove unreacted raw materials.

[0031] 6. Put the solid obtained in 5 into ethanol at 80°C for 1d to remove F127.

[0032] 7. Finally, the product from which F127 was removed in 6 was washed 3 times with ethanol. The target product Gd was obtained after vacuum drying at 60 °C for 24 h 80 Fe 20 . Ex...

Embodiment 2

[0033] 1. Dissolve 0.718g of F127 in 25mL of secondary deionized water, and sonicate at 50°C for 30min to fully dissolve it.

[0034] 2. Slowly add 0.189g of terephthalic acid, 0.04g of gadolinium trichloride and 0.164g of ferric chloride hexahydrate into the above solution, and continue to sonicate until a uniform and transparent solution is obtained.

[0035] 3. Put the transparent solution obtained in 2 into the hydrothermal reaction kettle, and react at 150°C for 24h.

[0036] 4. After the reaction, centrifuge the reaction solution to remove the secondary deionized water reaction solution.

[0037] 5. The crude product was then washed twice with N,N-dimethylformamide to remove unreacted raw materials.

[0038] 6. Put the solid obtained in 5 into ethanol at 80°C for 1d to remove F127.

[0039] 7. Finally, the product from which F127 was removed in 6 was washed 3 times with ethanol. The target product Gd was obtained after vacuum drying at 60 °C for 24 h 20 Fe80 .

Embodiment 3-6

[0041] The difference between embodiment 3-6 and embodiment 1~2 is shown in the table below:

[0042]

[0043] T 1 , T 2 Contrast agent structure and MR properties characterization

[0044] The JEM-2000EX transmission electron microscope produced by Japan JEOL Electronics Co., Ltd. and the MinMR-60 and NMI20 magnetic resonance instrument produced by Shanghai Numai Electronic Technology Co., Ltd. were used to analyze the blended contrast agent Gd prepared by the present invention. 80 Fe 20 and Gd 20 Fe 80 The particle size morphology and contrast agent imaging were characterized, and the results are as follows Figure 1~4 shown.

[0045] Figure 1~4 The blended contrast agent Gd prepared in Examples 1-2 of the present invention is shown 80 Fe 20 and Gd 20 Fe 80 The materials are evenly dispersed, the former resembles a mulberry structure and the latter resembles a needle-like structure, with sizes at 70nm (short end), 150nm (long end) and 140nm (short end), 890nm ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation method for a blending type contrast agent with T1 and T2 contrast functions. The method includes the steps of: dissolving a double-end amphiphilic organic template molecule in certain solvent, then adding aromatic acid, a rare earth chloride and a chloride of VIB-VIIIB group, and carrying out solvothermal reaction at an appropriate temperature, thus obtaining a blending type contrast agent nano-particle with T1 and T2 contrast functions. The blending type contrast agent material prepared by the method provided by the invention has a nanoscale particle size and good T1 and T2 contrast effects.

Description

technical field [0001] The invention belongs to the field of contrast agent materials, in particular to a 1 , T 2 A method for preparing a blended contrast agent with imaging function. Background technique [0002] In order to realize the dynamic monitoring of the targeting efficiency and therapeutic effect of gene or drug carriers on tumor tissues, contrast agents are usually introduced into the carriers. Because tumor tissue has a rich vascular network structure compared with normal tissue, contrast agents can be more enriched in tumor sites through the rich vascular network of tumor tissue and the permeability of blood vessel walls. The contrast agent can change the contrast between normal tissue and tumor tissue to achieve better observation of tumor tissue. [0003] According to the type of imaging enhancement, the currently used MRI contrast agents are divided into two categories: positive contrast agent T 1 and negative contrast agent T 2 . They respectively enh...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K49/06
Inventor 吴仁安刘荣徐桂菊张宇
Owner ZHANGJIAGANG IND TECH RES INST CO LTD DALIAN INST OF CHEM PHYSICS CHINESE ACADEMY OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com