Preparation method for blending type contrast agent with T1 and T2 contrast functions

A technology of contrast agent and function, which is applied in the field of preparation of blended contrast agent, which can solve the problems of brightening the enhanced picture and not being able to achieve image signals at the same time

Active Publication Date: 2014-12-03
ZHANGJIAGANG IND TECH RES INST CO LTD DALIAN INST OF CHEM PHYSICS CHINESE ACADEMY OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, under different scanning pulse sequences, for the same contrast agent, it is not possible to ac...

Method used

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  • Preparation method for blending type contrast agent with T1 and T2 contrast functions
  • Preparation method for blending type contrast agent with T1 and T2 contrast functions
  • Preparation method for blending type contrast agent with T1 and T2 contrast functions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Dissolve 0.718g of F127 in 25mL of secondary deionized water, and sonicate at 50°C for 30min to fully dissolve it.

[0027] 2. Slowly add 0.189g of terephthalic acid, 0.160g of gadolinium trichloride and 0.041g of ferric chloride hexahydrate into the above solution, and continue to sonicate until a uniform and transparent solution is obtained.

[0028] 3. Put the transparent solution obtained in 2 into the hydrothermal reaction kettle, and react at 150°C for 24h.

[0029] 4. After the reaction, centrifuge the reaction solution to remove the secondary deionized water reaction solution.

[0030] 5. The crude product was then washed twice with N,N-dimethylformamide to remove unreacted raw materials.

[0031] 6. Put the solid obtained in 5 into ethanol at 80°C for 1d to remove F127.

[0032] 7. Finally, the product from which F127 was removed in 6 was washed 3 times with ethanol. The target product Gd was obtained after vacuum drying at 60 °C for 24 h 80 Fe 20 . Ex...

Embodiment 2

[0033] 1. Dissolve 0.718g of F127 in 25mL of secondary deionized water, and sonicate at 50°C for 30min to fully dissolve it.

[0034] 2. Slowly add 0.189g of terephthalic acid, 0.04g of gadolinium trichloride and 0.164g of ferric chloride hexahydrate into the above solution, and continue to sonicate until a uniform and transparent solution is obtained.

[0035] 3. Put the transparent solution obtained in 2 into the hydrothermal reaction kettle, and react at 150°C for 24h.

[0036] 4. After the reaction, centrifuge the reaction solution to remove the secondary deionized water reaction solution.

[0037] 5. The crude product was then washed twice with N,N-dimethylformamide to remove unreacted raw materials.

[0038] 6. Put the solid obtained in 5 into ethanol at 80°C for 1d to remove F127.

[0039] 7. Finally, the product from which F127 was removed in 6 was washed 3 times with ethanol. The target product Gd was obtained after vacuum drying at 60 °C for 24 h 20 Fe80 .

Embodiment 3-6

[0041] The difference between embodiment 3-6 and embodiment 1~2 is shown in the table below:

[0042]

[0043] T 1 , T 2 Contrast agent structure and MR properties characterization

[0044] The JEM-2000EX transmission electron microscope produced by Japan JEOL Electronics Co., Ltd. and the MinMR-60 and NMI20 magnetic resonance instrument produced by Shanghai Numai Electronic Technology Co., Ltd. were used to analyze the blended contrast agent Gd prepared by the present invention. 80 Fe 20 and Gd 20 Fe 80 The particle size morphology and contrast agent imaging were characterized, and the results are as follows Figure 1~4 shown.

[0045] Figure 1~4 The blended contrast agent Gd prepared in Examples 1-2 of the present invention is shown 80 Fe 20 and Gd 20 Fe 80 The materials are evenly dispersed, the former resembles a mulberry structure and the latter resembles a needle-like structure, with sizes at 70nm (short end), 150nm (long end) and 140nm (short end), 890nm ...

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Abstract

The invention provides a preparation method for a blending type contrast agent with T1 and T2 contrast functions. The method includes the steps of: dissolving a double-end amphiphilic organic template molecule in certain solvent, then adding aromatic acid, a rare earth chloride and a chloride of VIB-VIIIB group, and carrying out solvothermal reaction at an appropriate temperature, thus obtaining a blending type contrast agent nano-particle with T1 and T2 contrast functions. The blending type contrast agent material prepared by the method provided by the invention has a nanoscale particle size and good T1 and T2 contrast effects.

Description

technical field [0001] The invention belongs to the field of contrast agent materials, in particular to a 1 , T 2 A method for preparing a blended contrast agent with imaging function. Background technique [0002] In order to realize the dynamic monitoring of the targeting efficiency and therapeutic effect of gene or drug carriers on tumor tissues, contrast agents are usually introduced into the carriers. Because tumor tissue has a rich vascular network structure compared with normal tissue, contrast agents can be more enriched in tumor sites through the rich vascular network of tumor tissue and the permeability of blood vessel walls. The contrast agent can change the contrast between normal tissue and tumor tissue to achieve better observation of tumor tissue. [0003] According to the type of imaging enhancement, the currently used MRI contrast agents are divided into two categories: positive contrast agent T 1 and negative contrast agent T 2 . They respectively enh...

Claims

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Application Information

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IPC IPC(8): A61K49/06
Inventor 吴仁安刘荣徐桂菊张宇
Owner ZHANGJIAGANG IND TECH RES INST CO LTD DALIAN INST OF CHEM PHYSICS CHINESE ACADEMY OF SCI
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