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Application of fatsia japonica branch and leaf extractives to anti-cancer drug preparation and preparation of fatsia japonica branch and leaf extractives

An octagonal golden plate and anti-cancer drug technology are applied in the directions of drug combination, anti-tumor drug, pharmaceutical formulation and the like, and achieve the effects of simple method, low cost and enhanced inhibitory effect.

Inactive Publication Date: 2015-01-07
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report about other pharmacological effects of the active ingredients in the star anise gold plate

Method used

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  • Application of fatsia japonica branch and leaf extractives to anti-cancer drug preparation and preparation of fatsia japonica branch and leaf extractives
  • Application of fatsia japonica branch and leaf extractives to anti-cancer drug preparation and preparation of fatsia japonica branch and leaf extractives
  • Application of fatsia japonica branch and leaf extractives to anti-cancer drug preparation and preparation of fatsia japonica branch and leaf extractives

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of the star anise gold plate branch and leaf extract specifically comprises the following steps:

[0028] (1) Dry the collected branches and leaves of the star anise gold plate in the shade to obtain 60g of the dried branches and leaves of the star anise gold plate, and mix it with the concentration of 95% ethanol mixed;

[0029] (2) Use 95% ethanol to soak the branches and leaves of the star anise gold plate overnight, and then ultrasonically extract 3 times. The temperature of the ultrasonic extraction is 50°C, the power is 200W, and each extraction is 0.5h, and then the ultrasonic extraction solution is filtered to obtain the filtrate 1 , then soak the filter residue with 95% ethanol at the same concentration as the initial ratio, and repeat the same extraction process above to obtain the filtrate 2-n until the 95% ethanol extract is colorless, and finally combine all the filtrates to obtain the total concentration 95% ethanol extract;

[0030] (3) ...

Embodiment 2

[0036] The preparation of the star anise gold plate branch and leaf extract specifically comprises the following steps:

[0037] (1) Dry the collected branches and leaves of the star anise gold plate in the shade to obtain 60g of the dried branches and leaves of the star anise gold plate, and mix it with the concentration of 95% ethanol mixed;

[0038] (2) Use 95% ethanol to soak the branches and leaves of the star anise gold plate overnight, and then ultrasonically extract 4 times. The temperature of the ultrasonic extraction is 65°C, the power is 200W, and each extraction is 1h, and then the ultrasonic extraction solution is filtered to obtain the filtrate 1. Then soak the filter residue with 95% ethanol with the same concentration as the initial ratio, repeat the above-mentioned identical extraction process, obtain filtrate 2-n, until the concentration 95% ethanol extract is colorless, finally combine all filtrates, and obtain a total concentration of 95 % ethanol extract;...

Embodiment 3

[0045] The preparation of the star anise gold plate branch and leaf extract specifically comprises the following steps:

[0046] (1) Dry the collected branches and leaves of the star anise gold plate in the shade to obtain 60g of the dried branches and leaves of the star anise gold plate, and mix it with the concentration of 95% ethanol mixed;

[0047] (2) Use 95% ethanol to soak the branches and leaves of the star anise gold plate overnight, and then ultrasonically extract 5 times, the temperature of ultrasonic extraction is 80°C, the power is 200W, each extraction is 2h, and then the ultrasonic extraction solution is filtered to obtain filtrate 1, Then soak the filter residue with 95% ethanol with the same concentration as the initial ratio, repeat the above-mentioned identical extraction process, obtain filtrate 2-n, until the concentration 95% ethanol extract is colorless, finally combine all filtrates, and obtain a total concentration of 95 % ethanol extract;

[0048] (...

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Abstract

The invention discloses application of fatsia japonica branch and leaf extractives to anti-cancer drug preparation and preparation of the fatsia japonica branch and leaf extractives, and belongs to the technical field of medicines and natural medicines. A preparation method of the fatsia japonica branch and leaf extractives includes the following steps: ethyl alcohol with 95-percent concentration serves as extracting agents; an ultrasonic extraction method is adopted for extracting fatsia japonica branches and leaves; total ethyl alcohol extractives of the fatsia japonica branch and leaf extractives are obtained; petroleum ether, chloroform and ethyl acetate are sequentially used for extracting the total ethyl alcohol extractives; a petroleum ether part, a chloroform part, an ethyl acetate part and an extraction remaining part are obtained. Meanwhile, supersonic extraction is carried out on the fatsia japonica branches and leaves obtained after extraction with the ethyl alcohol is carried out with distilled water, and an aqueous extract part is obtained. The five extraction parts of the fatsia japonica branches and leaves are of great significance in preparing medicines for treating the breast cancer, the non-small cell lung cancer and the human B-cell acute lymphoblastic leukemia.

Description

technical field [0001] The invention relates to the application and preparation of the extract of the branches and leaves of star anise jinpan in the preparation of anticancer drugs, and belongs to the technical field of medicines and natural medicines. Background technique [0002] Malignant tumors have always been a major disease that seriously threatens human health. According to the 2014 annual report of the International Cancer Research Center (IARC), according to the assessment results in 2012, the number of new cancer cases worldwide has increased to 14 million per year, and it is estimated that by 2030, there will be 22 million new cancer cases worldwide every year. Cancer deaths will also increase from an estimated 8.2 million per year to 13 million. In 2012, 1.8 million cases of lung cancer and 1.7 million cases of breast cancer were diagnosed, respectively accounting for 13% and 11.9% of the total cancer cases in that year. In recent years, the incidence of acut...

Claims

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Application Information

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IPC IPC(8): A61K36/25A61P35/00A61P35/02
CPCA61K36/25A61K2236/39A61K2236/35A61K2236/33A61K2236/331A61K2236/333
Inventor 赵扬梁超李拓潘卉冯阳
Owner KUNMING UNIV OF SCI & TECH
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