Bactericidal medical ultrasonic coupling agent for ultrasonic diagnosis of wound surfaces and preparation method of bactericidal medical ultrasonic coupling agent

Abstract

The invention provides a bactericidal medical ultrasonic coupling agent for the ultrasonic diagnosis of wound surfaces. The bactericidal medical ultrasonic coupling agent comprises 0.05-3% of carbomer, 1-20% of propanediol, 1-20% of glycerol, 0.1-5% of triethanolamine, 0.01-0.3% of triclosan, 0.05-10% of chitosan oligosaccharide, and 0.05-5% of menthol, the balance being purified water. The bactericidal medical ultrasonic coupling agent is prepared through the following steps: adding carbomer into the purified water, allowing the mixture to stand still overnight to obtain a solution A, fetching propanediol and glycerol through weighing for mixing, adding triclosan, chitosan oligosaccharide and menthol, and fully dissolving the substances to obtain a solution B; and adding the solution B in the solution A, stirring the mixture uniformly, adding triethanolamine, mixing the mixture fully, and obtaining the bactericidal medical ultrasonic coupling agent. The bactericidal medical ultrasonic coupling agent has a rapid broad-spectrum bactericidal effect, is good in acoustic performance, clear in image, high in resolution, and high in biocompatibility, has no cytotoxicity and mutagenicity, causes no allergy, and does not irritate the wound surfaces of skin. Moreover, a medical ultrasonic probe is not corroded.

Description

technical field [0001] The invention relates to a couplant, in particular to a bactericidal medical ultrasonic couplant for ultrasonic diagnosis of wounds and a preparation method thereof. Background technique [0002] In the process of ultrasonic diagnosis and treatment, it is necessary to use an ultrasonic neutral medium that is filled or coated between the radiating surface of the probe and the human epidermis and mucous membrane to transmit sound waves, that is, medical ultrasonic coupling agent. At present, the ultrasonic probe in ultrasonic examination is used repeatedly among patients at a high frequency, and is usually simply wiped after use by the patient. Although it may not necessarily cause the patient to be infected with pathogenic bacteria, there is still a great risk of cross-infection. Diseases that are easily transmitted are also good carriers. In today's environment where epidemic infectious diseases often break out on a large scale, the disinfection of med...

AI Technical Summary

Problems solved by technology

2. At present, the common high-efficiency disinfectants are often active in nature, which can not only react with pathogens, but also react with the human body, and can also react with the materials of the ultrasonic probe, which affects the service life of the probe

3. The active nature of the disinfectant often reacts with the probe and coupling agent, thus affecting the technical indicators of ultrasound

4. On the basis of solving the above problems, it is difficult to achieve rapid and powerful sterilization

If triclosan is simply added and the amount does not exceed 0.3%, it is difficult to kill pathogenic microorganisms in a short time (3 minutes)

Even individual disinfectant medical ultrasonic coupling agents compounded with bactericidal ingredients can achieve a bactericidal effect in a short period of time (3 minutes), but they have poor biocompatibility and cannot be used on wounds.

[0004] At present, self-proclaimed sterile ultrasonic coupling agents have appeared in the domestic market, but there is no real sterile ultrasonic coupling agent

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