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A group of genes used for prognosis of hormone receptor-positive breast cancer and applications thereof

A technology for hormone receptors and breast cancer, applied in the fields of application, genetic engineering, plant gene improvement, etc., to achieve the effects of sensitive parallel detection, easy operation, resolution of film reading results, and simple operation

Active Publication Date: 2015-01-07
FUDAN UNIV SHANGHAI CANCER CENT +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gene expression profiling data available abroad cannot be directly used for breast cancer in China

Method used

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  • A group of genes used for prognosis of hormone receptor-positive breast cancer and applications thereof
  • A group of genes used for prognosis of hormone receptor-positive breast cancer and applications thereof
  • A group of genes used for prognosis of hormone receptor-positive breast cancer and applications thereof

Examples

Experimental program
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Effect test

Embodiment Construction

[0044] In this example, the Chinese breast cancer population was taken as the research object, the breast cancer pathological tissue was used as the sample, and the multiple parallel detection liquid gene chip tool was used to carry out breast cancer typing and individualized drug guidance for the Chinese population.

[0045] Among them, the reagents used in the following experiments are commercial reagents unless otherwise specified.

[0046] (1) Sample collection and clinical information collection:

[0047] Collect retrospective samples of Chinese breast cancer population and collect clinical information, including: treatment options, complete clinical history, histopathological typing, histological grade, presence or absence of vascular invasion, lymph node status, hormone receptor status, immune group Chemical indicators, treatment conditions, follow-up data, etc., and establish a database. Fresh and frozen breast cancer tissue specimens collected from 2006 to the presen...

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Abstract

The invention discloses a group of genes used for prognosis of hormone receptor-positive breast cancer and applications thereof. The genes comprise genes ESR1, PGR, ERBB2 and MKI67. The applications of the genes include a multiple parallel detection liquid-phase gene chip used for the prognosis of the hormone receptor-positive breast cancer, a kit used for the prognosis of the hormone receptor-positive breast cancer and a gene evaluating system for the prognosis of the hormone receptor-positive breast cancer. By liquid-phase gene chip detection for the gene ESR1, the gene PGR, the gene ERBB2 and the gene MKI67, a large amount of film reading and identification by doctors in a pathology department can be largely reduced, doubtful film reading results in pathology are overcome, the accuracy is almost the same as that of IHC, and the genes and the applications are advantaged by being efficient and sensitive in parallel detection, easy in operation, and the like.

Description

technical field [0001] The invention relates to a gene and its application, in particular to a group of genes used for the prognosis of hormone receptor positive breast cancer and its application. Background technique [0002] Breast cancer is the most common malignancy and cause of death among women worldwide. With the development of my country's economy and the change of lifestyle, the incidence of breast cancer in China, especially in developed cities, shows a rapid upward trend (5% per year), and the annual number of new cases is close to 180,000. In megacities such as Shanghai, breast cancer has leapt to the top of the incidence rate of female malignant tumors. Due to the improvement of people's awareness of screening and the improvement of diagnosis and treatment, the mortality rate of breast cancer has decreased, and the 5-year survival rate of early breast cancer is as high as 90%. [0003] Hormone receptor-positive breast cancer accounts for 70-80% of all breast c...

Claims

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Application Information

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IPC IPC(8): C12Q1/68C12N15/12
CPCC12Q1/6886C12Q2600/118C12Q2600/158
Inventor 邵志敏黄晓燕徐晓晶孙冰玉赵莹
Owner FUDAN UNIV SHANGHAI CANCER CENT
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