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Application of dexamethasone sodium phosphate/layered double hydroxides as medicine for treating asthma and preparation method of dexamethasone sodium phosphate/layered double hydroxides

A technology of dexamethasone sodium phosphate and hydroxide, which is applied in the field of medicine, can solve problems such as aggravated infection, metabolic disorder, and life-threatening, and achieve the effect of treating asthma with high drug loading and easy handling

Inactive Publication Date: 2015-01-14
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] Glucocorticoids are currently the drug of choice for the clinical treatment of asthma. They can reduce airway inflammation, reduce airway hyperresponsiveness, reduce the hospitalization rate and mortality of asthmatic patients, and reduce the risk of admission to ICU and tracheal intubation for severe asthma attacks. However, long-term use can easily cause hypothalamus-pituitary-adrenal axis function inhibition, metabolic disorders, osteoporosis, hoarseness and throat discomfort, as well as induce and aggravate side effects such as infection, which can be disabled or life-threatening in severe cases. This double-edged sword effect has seriously affected the clinical efficacy and treatment compliance of glucocorticoid drugs. Therefore, how to maximize the therapeutic effect of these drugs while minimizing their adverse reactions has become a major issue. Important issues to be solved urgently in clinical and basic research

Method used

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  • Application of dexamethasone sodium phosphate/layered double hydroxides as medicine for treating asthma and preparation method of dexamethasone sodium phosphate/layered double hydroxides
  • Application of dexamethasone sodium phosphate/layered double hydroxides as medicine for treating asthma and preparation method of dexamethasone sodium phosphate/layered double hydroxides
  • Application of dexamethasone sodium phosphate/layered double hydroxides as medicine for treating asthma and preparation method of dexamethasone sodium phosphate/layered double hydroxides

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Experimental program
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Effect test

Embodiment 1

[0033] Embodiment 1: Preparation of dexamethasone sodium phosphate / layered double hydroxide nanomaterial

[0034] Step a: Preparation of MgCl 2 6H 2 O (0.6099g, 0.003mol) and AlCl 3 9H 2 O (0.2414 g, 0.001 mol) metal mixed salt solution total 10 mL;

[0035] Step b: the dexamethasone sodium phosphate of 0.516g (0.001mol) is dissolved in 40mL concentration and is the NaOH solution of 0.0006mol, makes it in N 2 Stirring at 60°C for 10 minutes under atmosphere;

[0036] Step c: Add the solution of step a dropwise to the solution of step b, N 2 Stir at 60°C for 3 hours under atmosphere.

[0037] Step d: Take out the sample after the reaction, centrifuge, use ddH 2 O water was repeatedly washed and centrifuged three times, transferred to a hydrothermal kettle, placed in an oven, and reacted at 100°C for 16 hours.

[0038] Step e: Centrifuge the sample, pour off the supernatant, put it in a vacuum drying oven at 50° C. for 48 hours and completely dry it, take it out, put it ...

Embodiment 2

[0039] Example 2: Characterization of Dexamethasone Sodium Phosphate / Layered Double Hydroxide

[0040]2.1. X-ray powder diffraction measurement was carried out on Rigaku D / max-rA X-ray powder diffractometer, the accelerating voltage and current were 40 kV and 40 mA, respectively, and the scan rate was 6° / min. Cu target (λ=0.154060nm), graphite monochromator.

[0041] It can be seen from the XRD spectrum that the dexamethasone sodium phosphate / layered double hydroxide nanocomposite has a layered crystal structure, and the diffraction peak position of the 003 crystal plane shifts to a lower 2θ compared with MgAl-Cl-LDHs, Therefore, it can be inferred that dexamethasone sodium phosphate has been inserted into the interlayer of LDHs.

[0042] 2.2. Take a small amount of dry sample powder, and use KBr tablet method for FTIR measurement, using a wavelength range of 4000-500 cm -1 Nicolet Fourier Transform Infrared Spectroscopy, pulverize the solid sample in an agate mortar, add p...

Embodiment 3

[0051] Embodiment 3: the establishment of asthmatic rat model and administration method

[0052] 3.1. Experimental grouping: A total of 20 clean-grade male SD rats, weighing 110g-130g, were randomly divided into normal group (saline), positive control group (Asthma group), and dexamethasone sodium phosphate administration group (Dexa group) , dexamethasone sodium phosphate-layered double hydroxide administration group (Dexa-LDHs group), layered double hydroxide group (LDHs group), 10 rats in each group, construction process and therapeutic intervention of asthma rat model Process such as Figure 4 shown.

[0053] Construction of Asthma Rat Model

[0054] 3.2. Asthma model group: after one week of adaptive feeding, the rat model of asthma was established by sensitization and challenge with ovalbumin.

[0055] Sensitization phase: 1 mL of 1 mg OVA and 10 mg Al(OH) was injected subcutaneously in the chest on day 0 and day 8 of OVA sensitization solution per mouse 3 The gel wa...

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Abstract

The invention belongs to the technical field of a biomedical material, and in particular relates to an application of dexamethasone sodium phosphate / layered double hydroxides in the aspect of treating asthma and a preparation method of the dexamethasone sodium phosphate / layered double hydroxides. For shortcomings of dexamethasone sodium phosphate, as a conventional glucocorticoid medicine, which is high in toxicity and poor in targeting, the dexamethasone sodium phosphate is loaded by layered double hydroxides, so as to improve a curative effect of the dexamethasone sodium phosphate and reduce toxic and side effects of the dexamethasone sodium phosphate. The prepared dexamethasone sodium phosphate / layered double hydroxides is relatively high in drug loading capacity and has a certain sustained-release effect; and the dexamethasone sodium phosphate / layered double hydroxides can inhibit egg albumin induced airway inflammation in asthmatic rats, and is expected to be applied to treatment of asthma diseases.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to an application of dexamethasone sodium phosphate / layered double hydroxide as an asthma medicine and a preparation method thereof. Background technique [0002] Asthma is a common respiratory disease that seriously endangers human health. In the past 40 years, with the increasing air pollution and the development of industrialization worldwide, its morbidity and mortality have been on the rise worldwide. . At present, there are no less than 300 million people suffering from this disease in the world. It is estimated that by 2025, the global asthma patients will increase to 400 million. At present, there are at least 30 million asthma patients in my country, of which the incidence rate of children is about 1.5%, and the incidence rate of adults is About 1%. The recurrence and deterioration of asthma have a serious impact on the quality of life of patients and bring a heavy economic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/661A61P11/06A61K47/69
Inventor 汪世龙朱融融孙晓宇王文锐
Owner TONGJI UNIV
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