Application of dexamethasone sodium phosphate/layered double hydroxides as medicine for treating asthma and preparation method of dexamethasone sodium phosphate/layered double hydroxides
A technology of dexamethasone sodium phosphate and hydroxide, which is applied in the field of medicine, can solve problems such as aggravated infection, metabolic disorder, and life-threatening, and achieve the effect of treating asthma with high drug loading and easy handling
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Embodiment 1
[0033] Embodiment 1: Preparation of dexamethasone sodium phosphate / layered double hydroxide nanomaterial
[0034] Step a: Preparation of MgCl 2 6H 2 O (0.6099g, 0.003mol) and AlCl 3 9H 2 O (0.2414 g, 0.001 mol) metal mixed salt solution total 10 mL;
[0035] Step b: the dexamethasone sodium phosphate of 0.516g (0.001mol) is dissolved in 40mL concentration and is the NaOH solution of 0.0006mol, makes it in N 2 Stirring at 60°C for 10 minutes under atmosphere;
[0036] Step c: Add the solution of step a dropwise to the solution of step b, N 2 Stir at 60°C for 3 hours under atmosphere.
[0037] Step d: Take out the sample after the reaction, centrifuge, use ddH 2 O water was repeatedly washed and centrifuged three times, transferred to a hydrothermal kettle, placed in an oven, and reacted at 100°C for 16 hours.
[0038] Step e: Centrifuge the sample, pour off the supernatant, put it in a vacuum drying oven at 50° C. for 48 hours and completely dry it, take it out, put it ...
Embodiment 2
[0039] Example 2: Characterization of Dexamethasone Sodium Phosphate / Layered Double Hydroxide
[0040]2.1. X-ray powder diffraction measurement was carried out on Rigaku D / max-rA X-ray powder diffractometer, the accelerating voltage and current were 40 kV and 40 mA, respectively, and the scan rate was 6° / min. Cu target (λ=0.154060nm), graphite monochromator.
[0041] It can be seen from the XRD spectrum that the dexamethasone sodium phosphate / layered double hydroxide nanocomposite has a layered crystal structure, and the diffraction peak position of the 003 crystal plane shifts to a lower 2θ compared with MgAl-Cl-LDHs, Therefore, it can be inferred that dexamethasone sodium phosphate has been inserted into the interlayer of LDHs.
[0042] 2.2. Take a small amount of dry sample powder, and use KBr tablet method for FTIR measurement, using a wavelength range of 4000-500 cm -1 Nicolet Fourier Transform Infrared Spectroscopy, pulverize the solid sample in an agate mortar, add p...
Embodiment 3
[0051] Embodiment 3: the establishment of asthmatic rat model and administration method
[0052] 3.1. Experimental grouping: A total of 20 clean-grade male SD rats, weighing 110g-130g, were randomly divided into normal group (saline), positive control group (Asthma group), and dexamethasone sodium phosphate administration group (Dexa group) , dexamethasone sodium phosphate-layered double hydroxide administration group (Dexa-LDHs group), layered double hydroxide group (LDHs group), 10 rats in each group, construction process and therapeutic intervention of asthma rat model Process such as Figure 4 shown.
[0053] Construction of Asthma Rat Model
[0054] 3.2. Asthma model group: after one week of adaptive feeding, the rat model of asthma was established by sensitization and challenge with ovalbumin.
[0055] Sensitization phase: 1 mL of 1 mg OVA and 10 mg Al(OH) was injected subcutaneously in the chest on day 0 and day 8 of OVA sensitization solution per mouse 3 The gel wa...
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