800nm-near-infrared-excited 1525nm-shortwave-infrared-emission fluorescence nano material and synthesis method thereof

A fluorescent nanomaterial and short-wave infrared technology, which is applied in the direction of luminescent materials, chemical instruments and methods, etc., can solve the problems of surrounding cells or tissue damage, and achieve the effect of low detection limit and deep penetration depth

Inactive Publication Date: 2015-01-14
FUDAN UNIV
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Problems solved by technology

Although rare earth probes based on Yb3+ can be excited by near-infrared light at 980 nm and applied to short-wave infrared imaging, some studies have shown that wa

Method used

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  • 800nm-near-infrared-excited 1525nm-shortwave-infrared-emission fluorescence nano material and synthesis method thereof
  • 800nm-near-infrared-excited 1525nm-shortwave-infrared-emission fluorescence nano material and synthesis method thereof
  • 800nm-near-infrared-excited 1525nm-shortwave-infrared-emission fluorescence nano material and synthesis method thereof

Examples

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Embodiment 1

[0024] (1) Preparation of the shell precursor.

[0025] Preparation of Yb, Er-OA (0.1 M) precursor: take a 50 mL three-neck round bottom flask as a reaction vessel, add 2.45 mmol YbCl 3 , 0.05 mmol ErCl 3 , 10 mL oleic acid (OA), 15 mL octadecene (ODE). Heated to 140 °C for 1 hour under vacuum and magnetic stirring conditions, and finally a clear and transparent Yb, Er-OA (0.1 M) precursor was obtained.

[0026] Preparation of Y, Yb-OA (0.1M) precursor: The preparation of Y, Yb-OA (0.1M) precursor is similar to the preparation of the above Yb, Er-OA (0.1 M) precursor, the above 2.45 mmol YbCl 3 , 0.05 mmol ErCl 3 Replaced with 2.25 mmol YCl, respectively 3 , 0.25 mmol YbCl 3 .

[0027] Preparation of Nd, Yb-OA (0.1M) precursor: The preparation of Nd, Yb-OA (0.1M) precursor is similar to the preparation of the above-mentioned Yb, Er-OA (0.1 M) precursor, and the above-mentioned 2.45 mmol YbCl 3 , 0.05 mmol ErCl 3 , 10 mL oleic acid (OA), 15 mL octadecene (ODE) were re...

Embodiment 2

[0038] Example 2: NaGdF prepared in embodiment 1 4 NaYbF 4 :ErNaYF 4 :YbNaNdF 4 : The surface of the Yb core-shell 1-shell 2-shell 3-core-shell structure nanocrystal is hydrophobic, and the modified amphiphile molecule can make the obtained nanocrystal water-soluble, so that it has better biocompatibility. The obtained water-soluble nanocrystals are incubated with cells, and the nanocrystals can enter cells through endocytosis. According to the short-wave infrared down-conversion fluorescence of the nanocrystals, the cells can be imaged with an infrared camera. In addition, the obtained water-soluble nanocrystals are injected into the mice through the tail vein, and the short-wave infrared down-conversion fluorescence of the nanocrystals can be used for in vivo imaging. Due to the precise optimization of this synthesis method and the advantage of 800 nm excitation light, the NaGdF 4 NaYbF 4 :ErNaYF 4 :YbNaNdF 4 : Yb core-shell 1-shell 2-shell 3-core-shell nanocrystals...

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Abstract

The invention belongs to the technical field of nano biological materials, and particularly relates to an 800nm-near-infrared-excited 1525nm-shortwave-infrared-emission fluorescence nano material and a synthesis method thereof. The fluorescence nano material is a one-core/three-shell core-shell structure nanocrystal material composed of a nucleating center, a shortwave infrared light-emitting layer, an energy transmission layer and an energy absorption layer, wherein the nucleating center provides a crystal core for growth of the other three layers and limits the particle size of the nanocrystal; the shortwave infrared light-emitting layer is used for absorbing exciting light with specific wavelength and emitting shortwave infrared light; the energy transmission layer is used for transmitting energy between the energy absorption layer and shortwave infrared light-emitting layer; and the energy absorption layer is used for absorbing energy and transferring the energy to the energy transmission layer. The three-layer structure design widens the exciting light from 980nm to 800nm or so, and implements the Nd<3+>->Yb<3+>->Er<3+> energy transfer process. Due to the ideal excitation and emission wavelengths, the material can be used for deep tissue in-vivo imaging.

Description

technical field [0001] The invention belongs to the technical field of nano-biological materials, and in particular relates to a nano-material with near-infrared excitation at 800 nm and short-wave infrared emission at 1525 nm and a synthesis method thereof. Background technique [0002] In the past ten years, biological imaging has attracted extensive attention from scientific researchers because of its outstanding performance in early diagnosis and treatment of diseases. Among the existing bioimaging techniques, tomographic imaging including CT, PET, MRI, etc. has been widely used because these tomographic imaging are not limited by the penetration depth. However, tomographic imaging has some unavoidable disadvantages, such as limited spatial resolution and inability to observe in real time (because it takes a long time to take pictures, and it often takes several minutes to tens of minutes to obtain a picture). In contrast, optical bioimaging based on the principle of ph...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/85
Inventor 张凡王睿
Owner FUDAN UNIV
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