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Application of trans-cassia twig acid in preparing drug for resisting bradyarrhythmia

A technology of trans-cinnamonic acid and arrhythmia, which can be used in drug combinations, cardiovascular system diseases, etc., can solve the problems of patients with bradyarrhythmias that cannot be effectively treated due to financial or technical reasons, and achieve a wide coverage of the disease and a good industry. The effect of chemical prospect and low cost

Inactive Publication Date: 2015-01-21
陈一江
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The technical purpose of the present invention is to provide a bradyarrhythmia drug that can be used for long-term treatment, which can be used to replace the pacemaker, and solve the technical problem that a large number of bradyarrhythmia patients cannot be effectively treated due to financial or technical reasons

Method used

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  • Application of trans-cassia twig acid in preparing drug for resisting bradyarrhythmia
  • Application of trans-cassia twig acid in preparing drug for resisting bradyarrhythmia
  • Application of trans-cassia twig acid in preparing drug for resisting bradyarrhythmia

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0058] Example 1: Effect of trans-cinnamonic acid on the heart rate of normal rats

[0059] Take 30 healthy rats, half male and half female, weighing 220±30g, and randomly divide them into: ①Cinnamic acid drug group, ②Blank group, ③Positive control group, 10 rats in each group, half male and half male. After one week of adaptive feeding in the experimental environment, the rats were generally in good condition, and gavage was started.

[0060] In the cinnamonic acid group, 50-250 mg / kg of trans-cinnamic acid was dissolved in 1-2-propanediol to prepare a saturated solution, which was administered by gavage continuously for 7 days. The positive control group was intraperitoneally injected with atropine 0.15 mg / kg;

[0061] 2 hours after the last gavage, the rats were weighed, and rats were anesthetized by intraperitoneal injection of 3% pentobarbital sodium 50 mg / kg. The supine position was fixed, and the needle electrodes were connected subcutaneously to the limbs. The electro...

example 2

[0070] Example 2: Effect of trans-cinnamic acid on the heart rate of rats with acetylcholine-induced bradycardia

[0071] 30 healthy rats, half male and half female, weighing 220±30g, were randomly divided into: ① cinnamic acid group, ② acetylcholine model group, 10 rats in each group, half male and half male. After one week of adaptive feeding in the experimental environment, the rats were generally in good condition, and gavage was started.

[0072] In the cinnamonic acid group, 50-250 mg / kg of trans-cinnamic acid was dissolved in 1-2-propanediol to prepare a saturated solution, which was administered by gavage continuously for 7 days. The saline group was intragastrically administered for 7 days, and the positive control group was intraperitoneally injected with atropine 0.15 mg / kg;

[0073] 2 hours after the last gavage, the rats were weighed, and rats were anesthetized by intraperitoneal injection of 3% pentobarbital sodium 50 mg / kg. The supine position was fixed, and th...

example 3

[0081] Trans-cinnamic acid has the effect of resisting the bradyarrhythmia of the acetylcholine rat model, and can increase the heart rate of the rat model. Example 3: Effect of trans-cinnamic acid on the heart rate of rats with bradycardia induced by verapamil

[0082] Take 30 healthy rats, half male and half female, weighing 220±30g, and randomly divide them into: ① cinnamic acid group, ② verapamil model group, ③ positive control group, 10 rats in each group, half male and half male. After one week of adaptive feeding in the experimental environment, the rats were generally in good condition, and gavage was started.

[0083] In the cinnamonic acid group, 50-250 mg / kg of trans-cinnamic acid was dissolved in 1-2-propanediol to prepare a saturated solution, which was administered by gavage continuously for 7 days. The equal-volume normal saline group was given continuous intragastric administration for 7 days, and the positive control group was intraperitoneally injected with ...

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Abstract

The invention discloses an application of trans-cassia twig acid in preparing a drug as shown in a formula I described in the specification for resisting bradyarrhythmia. The trans-cassia twig acid is relatively low in cost in comparison with the natural cassia twig acid, capable of being largely synthesized and produced and pushing the development of a traditional Chinese medicine preparation for resting bradycardia, and relatively good in industrial prospect.

Description

technical field [0001] The invention relates to the application of trans-cinnamic acid in the preparation of anti-bradyarrhythmia drugs. Background technique [0002] Bradyarrhythmia refers to a variety of arrhythmias with an effective heart rate of less than 60 beats per minute, characterized by slowing of the heart rate. Clinically, the patient will have symptoms of insufficient blood supply to the heart, brain and other organs related to insufficient cardiac output, such as dizziness, fatigue, chest tightness, shortness of breath, etc. Patients with coronary heart disease may have angina pectoris, syncope and pre-syncope are related to severe cardiac rhythm The most common symptoms associated with severe disease, death can occur in severe cases. Decreased self-discipline, various conduction blocks and cardiomyopathy, autonomic neuropathy, and deterioration of the myocardial microenvironment are the main mechanisms for the pathogenesis of bradyarrhythmias. [0003] At pr...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61P9/06
CPCA61K31/192
Inventor 陈一江罗琳陈宸
Owner 陈一江
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