A preparation method of a pharmaceutical composition for treating osteoarthritis

A technology for osteoarthritis and composition, which is applied in the field of preparation of pharmaceutical compositions, and can solve problems such as liver damage and adverse reactions

Active Publication Date: 2019-08-02
CHINA RESOURCES SANJIU MEDICAL & PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] For this reason, the technical problem to be solved by the present invention is that there is a certain liver injury adverse reaction problem in the medicine for the treatment of osteoarthropathy in the prior art, and then develop a kind of medicine that can effectively treat osteoarthropathy with lower hepatotoxicity damage Method for preparing the composition

Method used

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  • A preparation method of a pharmaceutical composition for treating osteoarthritis
  • A preparation method of a pharmaceutical composition for treating osteoarthritis
  • A preparation method of a pharmaceutical composition for treating osteoarthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0234] [Prescription] 576.8 grams of Goji, 346.1 grams of Epimedium, 346.1 grams of Duhuo, 462.0 grams of Rhizoma Drynariae, 576.8 grams of Dipsacus, 576.8 grams of Sangji, 346.1 grams of Spatholobus, 1384.2 grams of Rehmannia glutinosa, 346.1 grams of Muxiang, 346.1 grams of frankincense, 346.1 grams of myrrh, and 346.1 grams of psoralen.

[0235] 【Preparation】

[0236] Mix the frankincense and myrrh according to the selected weight, add 10 times the amount of water for steam distillation and extraction for 12 hours, and collect the volatile oil; according to the mass ratio of volatile oil: β-cyclodextrin: water: ethanol is 1:10: Add auxiliary materials at a ratio of 20:1, grind for 20 minutes for inclusion, dry and pulverize within 50°C, pass through a 120-mesh sieve, and make volatile oil inclusion compound for later use;

[0237] Take the psoralen according to the selected weight, add 8 times the amount of water to extract twice, 1 hour each time, discard the water extrac...

Embodiment 2

[0240] [Prescription] 290 grams of dog ridge, 520 grams of epimedium, 154 grams of solitary, 692 grams of rhizoma drynaria, 290 grams of diapsacus, 864 grams of mulberry root, 154 grams of milletus, 2076 grams of Rehmannia glutinosa, 154 grams of woody fragrance, 520 grams of frankincense, 154 grams of myrrh and 520 grams of psoralen.

[0241] 【Preparation】

[0242] Mix the frankincense and myrrh according to the selected weight, add 8 times the amount of water for steam distillation and extraction for 15 hours, and collect the volatile oil; according to the mass ratio of volatile oil: β-cyclodextrin: water: ethanol is 1:8: Add auxiliary materials at a ratio of 24:1, grind for 20 minutes for inclusion, dry and pulverize within 50°C, and make volatile oil inclusion compound for later use;

[0243] Take the psoralen according to the selected weight, add 6 times the amount of water to extract 3 times, each time for 0.5 hours, discard the water extract, collect the dregs, and dry...

Embodiment 3

[0246] [Prescription] 864 grams of dog ridge, 154 grams of epimedium, 520 grams of solitary, 224 grams of rhizoma drynaria, 864 grams of Dipsacus, 290 grams of mulberry, 520 grams of milletus, 692 grams of Rehmannia glutinosa, 520 grams of woody fragrance, 154 grams of frankincense, 520 grams of myrrh and 154 grams of psoralen.

[0247] 【Preparation】

[0248]Mix the frankincense and myrrh according to the selected weight, add 12 times the amount of water for steam distillation and extraction for 8 hours, and collect the volatile oil; according to the mass ratio of volatile oil: β-cyclodextrin: water: ethanol is 1:12: Add auxiliary materials at a ratio of 16:2, grind for 20 minutes for inclusion, dry and pulverize within 50°C, and make volatile oil inclusion compound for later use;

[0249] Take the psoralen according to the selected weight, add 10 times the amount of water to extract once for 0.5 hours, discard the water extract, collect the dregs, and dry to obtain the proce...

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a preparation method of a pharmaceutical composition for treating osteoarthrosis. According to the preparation method disclosed by the invention, the pharmaceutical composition is prepared from rhizoma cibotii, herba epimedii, radix angelicae pubescentis, drynaria rhizome, teasel root, parasitic loranthus, caulis spatholobi, prepared rehmannia root, elecampane, and processed products of olibanum volatile oil, myrrh essential oil and fructus psoraleae as medicines. The pharmaceutical composition prepared by the method is capable of effectively treating osteoarthritis and lumbar muscle degeneration caused by deficiency of the liver and kidneys, qi-stagnation and blood stasis, and vein stagnation, is capable of effectively reducing hepatic toxic side effects of original products, and has relatively good clinical treatment effects.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a preparation method of a pharmaceutical composition for treating osteoarthritis. Background technique [0002] Osteoarthritis (OA) is a common chronic joint disease, the main lesion is the degeneration of articular cartilage and secondary bone hyperplasia. Degenerative osteoarthropathy refers to a series of degenerative lesions in the human body, such as joint pain, stiffness, and limited mobility. It is a comprehensive disease. Its incidence rate is only second to heart disease in the crowd over 50 years old, and the incidence rate in the crowd over 65 years old is as high as 60-90%, especially brings great pain and inconvenience to the life of middle-aged and elderly people. [0003] Lumbar muscle strain is also the most common type of pain in low back pain, and is often used as a general term for chronic low back pain without organic chang...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K36/804A61P19/02
CPCA61K9/2068A61K9/2833A61K36/11A61K36/126A61K36/185A61K36/232A61K36/285A61K36/296A61K36/324A61K36/328A61K36/486A61K36/487A61K36/804A61K47/6951A61K2236/331A61K2300/00
Inventor 马鹏岗代志刘志刚徐冰王勇王跃飞李琼娅赵枫林王静周昆李霞
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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