Pharmaceutical composition with improved stability comprising extracts of natural products

A composition and extract technology, which is applied in drug delivery, medical preparations containing active ingredients, sugar-coated pills, etc., can solve the problems of increasing the total weight of finished products, reducing the content of active ingredients, and the stability of natural extracts with low moisture content , to achieve the effect of ensuring stability and improving mixability

Pending Publication Date: 2022-07-08
GREEN CROSS HEALTH SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this case, there is a problem of reduced stability when mixing natural extracts and additives and subsequent storage of finished products, such as reducing the content of active ingredients contained in natural extracts
In addition, natural extracts themselves have very low moisture content stability, so there is also a problem that a water-repellent coating treatment is required on the surface of the drug, so the total weight of the finished product increases

Method used

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  • Pharmaceutical composition with improved stability comprising extracts of natural products
  • Pharmaceutical composition with improved stability comprising extracts of natural products
  • Pharmaceutical composition with improved stability comprising extracts of natural products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] [Example 1] Preparation of Granules Extract of Viola

[0051]First, the whole plant of A. violacea and the same genus were washed with distilled water and finely ground with a grinder, and then heated in boiling water at 100°C to 120°C for 2 to 3 hours to obtain a viscous liquid N. japonica extract (when heating, install a cooler To maintain a predetermined temperature and prevent loss of steam), about 60% by weight of maltodextrin was added to the obtained N. japonica extract, followed by grinding and powder granulation to prepare N. japonica extract granules.

Embodiment 2

[0062] [Example 2] Preparation of pharmaceutical composition (unfinished product) containing extract of Viola

[0063] According to the composition of Table 3 below, a pharmaceutical composition (800 mg) containing the extract of Nitella sativa was prepared, which ensures moisture stability while minimizing additives, and the specific properties and performances of the composition are as follows.

[0064] - A composition for the purpose of ensuring stability for a certain period of time and completing disintegration within 30 minutes even after removal of solubilizers and disintegrants such as sodium bicarbonate.

[0065] - Using more than 50% of crystalline cellulose based on the total weight, the purpose is to ensure the stability of the natural extract which is susceptible to moisture.

[0066] - No water repellent coating base was used to minimise changes in stilbene and moisture content.

[0067] - When considering tablet size, etc., by setting the total weight of the ...

Embodiment 3

[0070] [Example 3] Preparation of pharmaceutical composition (finished product) containing extract of Viola

[0071] According to the composition of Table 4 below, even while maintaining the characteristics and properties of the pharmaceutical composition (unfinished product) prepared in Example 2, the total weight was reduced while maintaining stability to prepare Pharmaceutical composition (600 mg). In other words, the composition ensuring the stability of the raw material is prepared by mainly reducing the ratio or content of crystalline cellulose and coating matrix.

[0072] [Table 4]

[0073]

[0074]

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PUM

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Abstract

Disclosed is a pharmaceutical composition having improved stability comprising an extract of a natural product, in which the content of an active ingredient in the extract is stably maintained by adding only a small amount of an additive to an extract of a whole plant of Chrysanthemum indicum or a related plant of the same genus, and the stability of the extract is improved. The extract is effective for preventing and treating osteoarthropathy and the like but is susceptible to moisture, and the pharmaceutical composition can ensure various stability with respect to moisture and the like when formulated into a drug. The pharmaceutical composition having improved stability comprising a natural product extract comprises particles of a Chrysanthemum indicum extract obtained by mixing the Chrysanthemum indicum extract and a dextrin-based compound and granulating the mixture.

Description

technical field [0001] This application claims the benefit of priority based on Korean Patent Application No. 10-2019-0076519 filed on Jun. 26, 2019, the entire contents of which are incorporated herein by reference. [0002] The present invention relates to a pharmaceutical composition with improved stability comprising a natural product extract, and more particularly, to a pharmaceutical composition with improved stability comprising a natural product extract, wherein the (Chrysanthemum zawadskii) or the whole plant extract of the same genus, only a small amount of additives are added to stably maintain the content of active ingredients in the extract, which is effective for prevention and treatment of osteoarthritis and the like but is susceptible to Influenced by moisture, the pharmaceutical composition can ensure various stability to moisture and the like when formulated into a drug. Background technique [0003] Arthritis is a disease that causes joint inflammation an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16
CPCA61K9/1652A61K9/205A61K9/0053A23L33/105A61K36/287A23P10/20A61K9/2059A61K9/1611A61K9/1617A61K9/2054A61K9/2866A23V2002/00A23V2250/5114A23V2250/5112A23V2200/306
Inventor 林洛贤李宗勋林洙焕金点溶朴宣奎
Owner GREEN CROSS HEALTH SCI
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