New application of drug residues after alcohol extraction of American cockroach

A technology of Periplaneta americana and Periplanetaol, applied in drug combination, medical raw materials derived from arthropods, digestive system, etc.

Active Publication Date: 2015-02-25
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current utilization of Periplaneta americana focuses on its water

Method used

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  • New application of drug residues after alcohol extraction of American cockroach
  • New application of drug residues after alcohol extraction of American cockroach
  • New application of drug residues after alcohol extraction of American cockroach

Examples

Experimental program
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Embodiment 1

[0023] 1 Experimental materials

[0024] 1.1 Experimental animals

[0025] KM male mice, weighing 18-22 g, were provided by Chengdu Dashuo Biotechnology Co., Ltd., and the certificate number of experimental animals was scxkc(111)2008-24.

[0026] 1.2 Experimental drugs

[0027] ① Tiopronin enteric-coated tablets (Henan Xinyi Pharmaceutical Co., Ltd., batch number: 120704), ground, dissolved in 0.5% sodium carboxymethylcellulose aqueous solution, and made into a 2.5mg / mL solution, in the form of a suspension; Store in the refrigerator at 4°C and shake well when used.

[0028] ② Preparation of alcohol extraction sample solution:

[0029] Sample 1: Periplaneta americana (Sichuan Kelun Natural Pharmaceutical Co., Ltd., batch number 120401), dried at 50°C, powdered, crushed, passed through a No. 1 sieve, 100g of powder was taken, extracted with 85% ethanol under reflux, and 7 Double the amount of extraction for 2 hours, the second time add 5 times the amount of extraction for 1...

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Abstract

The present invention provides new application of drug residues after alcohol extraction of American cockroach in preparation of anti hepatic injury drugs. According to the studies, the drug residues after alcohol extraction of American cockroach are effective on the treatment of hepatic injury, especially alcohol hepatic injury, and improve the utilization rate of the resources of medicinal materials.

Description

technical field [0001] The invention relates to a new application of the medicinal residue after alcohol extraction of the American cockroach. Background technique [0002] In recent years, the number of diseases caused by alcohol dependence has increased dramatically worldwide and has become a growing public health problem in the world today. 【1】 . As we all know, a large amount of alcohol intake in a short period of time can cause acute liver damage, long-term heavy drinking can cause alcoholic liver disease (Alcoholic liver disease, ALD), and the incidence of ALD is also increasing year by year. Alcohol has become the second viral disease in my country. Second leading cause of liver damage after hepatitis 【2】 . ALD includes mild alcoholic liver disease, alcoholic fatty liver, alcoholic hepatitis, alcoholic liver fibrosis, and alcoholic cirrhosis 【3】 . Therefore, it has become a major research approach to find active substances for treating liver diseases from Chinese ...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P1/16
CPCA61K35/63
Inventor 王达宾张帅杰苏柘僮邹俊波熊永爱姜小东郭华
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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