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Leucorrhea treatment capsules and preparation method thereof

A technology of capsules and red belts, applied in the field of Zhidai capsules and its preparation, can solve the problems of slow disintegration, unsatisfactory curative effect, and low curative effect

Inactive Publication Date: 2015-03-04
HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of Zhidai Capsules on the market is not ideal due to the composition and process. The preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect.

Method used

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  • Leucorrhea treatment capsules and preparation method thereof
  • Leucorrhea treatment capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 26g of Citrus aurantii, 195g of Persica radiata, 195g of Sophora flavescens, 260g of Rosa chinensis, and 130g of Atractylodes atractylodes, crush them into a 60-mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, extraction pressure 30Mpa, extraction temperature 30 ℃, separator pressure 10Mpa , the temperature of the separator is 50°C, the separation time is 2 hours, and the flow rate of carbon dioxide is 40L per hour to obtain the extract; the extract is dried under reduced pressure at 60°C to obtain a dry paste; Grind into a mixed dry cream powder with a particle size of 200-300nm; take the mixed dry cream powder, 45g of microcrystalline cellulose, 45g of cross-linked polyvinylpyrrolidone, and 35g of cross-linked carboxymethylcellulose sodium, mix well, and wet with 50% ethanol Granulate by law, dry at 60°C, add 7 g of sodium carboxymethyl starch, 1 g of magnesium stearate, whole grain, and pack into capsules to obtain 1000 Zhida...

specific Embodiment 2

[0026] Take 26g of Citrus aurantii, 195g of Cyperus cypress, 195g of Sophora flavescens, 260g of Rosa chinensis, and 130g of Atractylodes atractylodes, crush them into a 60-mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, the extraction pressure is 40Mpa, the extraction temperature is 40°C, and the separator pressure is 20Mpa , the temperature of the separator is 60°C, the separation time is 4 hours, the flow rate of carbon dioxide is 50L per hour, and the extract is obtained; the extract is dried under reduced pressure at 80°C to obtain a dry paste; Grind into a mixed dry cream powder with a particle size of 200-300nm; take the mixed dry cream powder, 55g of microcrystalline cellulose, 55g of cross-linked polyvinylpyrrolidone, and 45g of cross-linked sodium carboxymethylcellulose, mix well, and wet with 70% ethanol Granulate by law, dry at 80°C, add 9 g of sodium carboxymethyl starch, 3 g of magnesium stearate, whole grain, pack into capsu...

Embodiment 3

[0028] Take 26g of Citrus aurantium, 195g of Persica radiata, 195g of Sophora flavescens, 260g of Rosa chinensis, and 130g of Atractylodes atractylodes, crush them into 60-mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, extraction pressure is 35Mpa, extraction temperature is 35°C, separator pressure is 15Mpa , the temperature of the separator is 55°C, the separation time is 3 hours, and the flow rate of carbon dioxide is 45L per hour to obtain the extract; take the extract and dry it under reduced pressure at 70°C to obtain a dry paste; add 175g of aspartame to the dry paste, and use a high-energy nano impact mill Grind into a mixed dry cream powder with a particle size of 200-300nm; take the mixed dry cream powder, 50g of microcrystalline cellulose, 50g of cross-linked polyvinylpyrrolidone, and 40g of cross-linked carboxymethylcellulose sodium, mix well, and wet with 60% ethanol Granulate by law, dry at 70°C, add sodium carboxymethyl star...

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Abstract

The invention discloses leucorrhea treatment capsules and a preparation method thereof. The preparation method is characterized in that 26 g of fructus aurantii immaturus, 195 g of cortex periplocae, 195 g of radix sophorae flavescentis, 260 g of rosa laevigata michx and 130 g of rhizoma atractylodis are taken, carbon dioxide supercritical extraction is conducted on the matierals, the extracts are dried under reduced pressure and ground into nano dry paste with a high-energy nano impact mill; a functional auxiliary material is added into the dry paste to prepare the leucorrhea treatment capsules. The disintegration time is shortened obviously, the curative effect is obviously superior to that of commercially available leucorrhea treatment capsules, and the effect is positive.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a Zhidai capsule and a preparation method thereof. Background technique [0002] Zhidai Capsule clears dampness and heat, stops belt. Betting for hot and humid, red belt, leucorrhea, yellow belt. The curative effect of Zhidai Capsules on the market is not ideal due to the composition and process, and the preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect. Contents of the invention [0003] In order to overcome the above disadvantages, the present invention provides a Zhidai capsule with fast disintegration speed and high curative effect and a preparation method thereof. [0004] Invention embodiment is as follows: [0005] Take 26g of Citrus aurantium, 195g of Cyperus cypress, 195g of Sophora flavescens, 260g of Rosa japonica, and 130g of Atractylodes atractylodes, crush them into 60 mesh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K9/48A61K47/38A61P15/00
CPCA61K36/752A61K9/0053A61K9/4866A61K36/27A61K36/284A61K36/489A61K36/738A61K2236/15A61K2236/37A61K2236/51
Inventor 不公告发明人
Owner HEILONGJIANG JIANGHENG PHARMA TECH CO LTD