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New sesquiterpene compound as well as preparation method and medical application thereof

A compound and chemical structural formula technology, applied in the field of natural medicinal chemistry, can solve problems such as loss of chemical components

Inactive Publication Date: 2015-03-04
XINING YIGE INTPROP CONSULTING SERVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when using the traditional steaming process to prepare warm curcuma, the water vapor can take away the volatile oil components, resulting in the loss of chemical components

Method used

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  • New sesquiterpene compound as well as preparation method and medical application thereof
  • New sesquiterpene compound as well as preparation method and medical application thereof
  • New sesquiterpene compound as well as preparation method and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Take 10Kg of Wenyujin, crush it into small pieces, wrap it with absorbent cotton, put it in an autoclave, and steam it 3 times, 120 minutes each time. After steaming thoroughly, take out the warm turmeric and let it cool, and recycle the aqueous solution in the autoclave at the same time. Extract the steamed turmeric with 70% ethanol three times (30L×3), recover under reduced pressure until there is no alcohol smell, combine it with the aqueous solution in the autoclave, filter, and collect the filtrate. The filtrate was enriched with D101 macroporous resin, and eluted with pure water, 30% ethanol, 60% ethanol and 910% ethanol respectively, and each concentration of ethanol solution was eluted for 6 column volumes, and the eluted part of 60% ethanol was collected and depressurized. Concentrated into an extract (280g).

[0043] The extract (280g) was subjected to column chromatography on normal phase silica gel (800g), and eluted with dichloromethane-methanol to obtain ...

Embodiment 2

[0045] Take 10Kg of Wenyujin, crush it into small pieces, wrap it with absorbent cotton, put it in an autoclave, and steam it 3 times, 120 minutes each time. After steaming, take out the warm turmeric and let it cool. Extract the steamed turmeric with 70% ethanol three times (30L×3), recover under reduced pressure until there is no alcohol smell, filter, and collect the filtrate. The filtrate was enriched with D101 macroporous resin, and eluted with pure water, 30% ethanol, 60% ethanol and 910% ethanol respectively, and each concentration of ethanol solution was eluted for 6 column volumes, and the eluted part of 60% ethanol was collected and depressurized. Concentrate into an extract (250g).

[0046] The extract (250g) was subjected to column chromatography on normal phase silica gel (800g), and eluted with dichloromethane-methanol to obtain dichloromethane-methanol (volume ratio 40:1) eluate, which was concentrated to obtain extract E1 . Take the extract E1 and perform si...

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Abstract

The invention provides a new sesquiterpene compound separated from curcuma wenyujin, as well as a preparation method and the medical application of the new sesquiterpene compound. The invention discloses the new sesquiterpene compound. The preparation method of the compound is implemented by use of a high-pressure airtight steaming process so as to prevent the compound from being brought away by water vapor, and therefore, the yield of the compound is increased. The new sesquiterpene compound can be used an active ingredient for preparing anticoagulant and antithrombotic drugs.

Description

technical field [0001] The invention relates to the field of natural medicinal chemistry, in particular to a new sesquiterpene compound isolated from curcuma vinifera, a preparation method and its medical application for preparing anticoagulant and antithrombotic drugs. Background technique [0002] Sesquiterpene refers to a natural terpenoid compound with 15 carbon atoms in the molecule. It is a special chemical substance formed by the use of primary metabolites by organisms under the catalysis of a series of enzymes. Sesquiterpenes often exist in volatile oils in the form of alcohols, ketones, and lactones in plants, and are the main components of high boiling point parts in volatile oils. Compared with other terpenoids, sesquiterpenoids can exhibit activities such as anthelmintic, anti-inflammatory, anti-tumor, antihypertensive and sedative, and are widely used in the synthesis of drug prodrugs, screening of active compounds and development of new drugs and other researc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/93A61P7/02
CPCC07D307/93
Inventor 周同永
Owner XINING YIGE INTPROP CONSULTING SERVICE
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