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Antiretroviral composition

A technology of anti-retrovirus and composition, which can be used in anti-viral agents, drug delivery, microcapsules, etc., and can solve expensive problems

Inactive Publication Date: 2015-03-11
CIPLA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, all such techniques involve the use of complex methods or systems and are expensive

Method used

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  • Antiretroviral composition
  • Antiretroviral composition
  • Antiretroviral composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0152] method:

[0153] (1) Prepare a dry mixture of lopinavir, ritonavir and colloidal silicon dioxide.

[0154] (2) Add sorbitan monolaurate to the copovidone in a suitable granulator to form a polymer premix separately.

[0155] (3) Mix the dry mixture obtained in step (1) and step (2) in a suitable granulator and melt extrude (hot).

[0156] (4) Colloidal silicon dioxide was mixed with dry granules and lubricated by using sodium stearyl fumarate.

[0157] (5) Compress the lubricated granules into microtablets.

[0158] (6) Coat the compressed microtablets with a seal coat solution.

[0159] (7) Filling the microtablets obtained in step (6) into hard gelatin capsules.

Embodiment 2

[0161]

[0162] method:

[0163] 1. Prepare a dry mixture of ritonavir, colloidal silicon dioxide and Eudragit.

[0164] 2. Extrude the dry mixture obtained in step (1) using a hot-melt extrusion technique.

[0165] 3. The extrudate obtained in step (2) is sized and sieved to form granules.

[0166] 4. Mix the granules obtained in step (3) with colloidal silicon dioxide and sugar.

Embodiment 3

[0168]

[0169] method:

[0170] 1. Prepare a dry mixture of ritonavir, colloidal silicon dioxide, sugar and Eudragit.

[0171] 2. Extrude the dry mixture obtained in step (1) using a hot-melt extrusion technique.

[0172] 3. The extrudate obtained in step (2) is sized and sieved to form granules.

[0173] 4. Add colloidal silicon dioxide and mix the granules obtained in step (3).

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Abstract

The present invention provides a pharmaceutical solid oral sprinkle composition comprising one or more antiretroviral drugs, and a method of manufacturing the same. The present invention is particularly useful for treatment of an HIV infection, AIDS related complex, or AIDS.

Description

field of invention [0001] The present invention relates to a solid oral sprinkle pharmaceutical composition comprising one or more antiretroviral drugs such as ritonavir, a process for its preparation and the use of said composition in the treatment of diseases caused by retroviruses , especially the use of acquired immunodeficiency syndrome or HIV infection. In particular, the invention relates to sprinkle formulations comprising one or more antiretroviral drugs such as ritonavir. Background technique [0002] Acquired immunodeficiency syndrome (AIDS) results in a gradual breakdown of the body's immune system and progressive deterioration of the central and peripheral nervous systems. Two different retroviruses, human immunodeficiency virus (HIV) type 1 (HIV-1) or type 2 (HIV-2), have been etiologically associated with this immunosuppressive disease, acquired immunodeficiency syndrome (AIDS) associated. HIV seropositive individuals are initially asymptomatic but often de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/20A61K31/427A61K31/513
CPCA61K31/513A61K9/2072A61K31/427A61K9/1611A61K45/06A61K9/1635A61K31/426A61P31/18A61K2300/00A61K9/0053A61K9/1617A61K9/1623A61K9/5073A61K9/5084A61K9/5089
Inventor S·M·普兰德尔G·马尔霍特拉
Owner CIPLA LTD
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