A kind of instant berberine preparation and preparation method and application thereof

A technology of berberine and instant dissolving, applied in the field of medicine, can solve the problems of complicated process, only reaching 2%, polluting the environment, etc., and achieve the effect of strong hydrophilicity

Active Publication Date: 2016-04-13
TIANJIN AGRICULTURE COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, use commonly used emulsifiers and emulsification aids to emulsify berberine, but the amount of emulsifier is much higher than that of berberine, and its solubility can only reach about 2%.
Improve the solubility of berberine through chemical modification, although the solubility has been further improved, but the process is complicated, the cost is high, and the environment is polluted

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0017] The preparation method of instant berberine preparation of the present invention comprises the following steps:

[0018] (1) Synthesis of negatively charged hydrophilic resin: add acrylic acid or methacrylic acid, emulsifier, chain transfer agent, and initiator to water, and carry out emulsion polymerization at 70-85°C for 30-90 minutes; then add hydroxy acrylate or methyl Hydroxyl acrylate, continue to polymerize for 20-50min; heat up to 90-95°C, add acrylate or methacrylate, initiator, polymerize for 30-90min; after polymerization is complete, after cooling down, add neutralizer to neutralize, neutralization degree 70-90% to obtain a negatively charged hydrophilic resin with a solid content of 15-30%; in parts by mass, the acrylic acid or methacrylic acid: hydroxy acrylate or hydroxy methacrylate: acrylate or methacrylate =1-6:0.5-6:1-5.5; the amount of water is 2-5 times of the total mass of polymerized monomers;

[0019] (2) Add berberine to the negatively charged ...

Embodiment 1

[0029] Synthesis of negatively charged hydrophilic resin: In a 250mL round bottom flask equipped with a stirring bar and a reflux device, add 30mL of water, 0.3g of polyethylene glycol lauryl ether, 0.2g of polyethylene glycol laurate, 6g of acrylic acid, 1 g of isopropanol and 0.02 g of potassium persulfate were stirred and heated to 75° C. for 1 h of polymerization. Add 6 g of hydroxyethyl acrylate and continue polymerization for 0.5 h. Then the temperature was raised to 90°C, 5 g of butyl acrylate was added, 10 mL of an aqueous solution containing 0.01 g of potassium persulfate was added, and polymerization was carried out for 1 h. The temperature was lowered to room temperature, and 13.5 g of an aqueous solution containing 3.5 g of potassium hydroxide was added dropwise with stirring to obtain a viscous negatively charged hydrophilic resin.

Embodiment 2

[0031] Synthesis of negatively charged hydrophilic resin: In a 250mL round bottom flask equipped with a stirring bar and a reflux device, add 30mL of water, 0.5g of polyethylene glycol laurate, 6g of methacrylic acid, 1g of isopropanol, and potassium persulfate 0.02g, stirred and heated to 80°C for 1h polymerization. Add 6 g of hydroxyethyl methacrylate and continue polymerization for 0.5 h. Then the temperature was raised to 90°C, 5 g of butyl methacrylate was added, 10 mL of a solution containing 0.01 g of ammonium persulfate was added, and polymerization was carried out for 1 h. The temperature was lowered to room temperature, and 13.3 g of a solution containing 3.3 g of potassium hydroxide was added dropwise with stirring to obtain a viscous negatively charged hydrophilic resin.

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PUM

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Abstract

The invention discloses an instant berberine preparation, a preparation method and application of the instant berberine preparation. By utilizing strong electrostatic interaction between synthesized polyacrylic resin and berberine molecules, the solubility of the berberine is greatly improved; the synthesized instant berberine can be mixed and dissolved in water according to any proportion, so that the solubility of the berberine is increased by more than 200 times. The synthesis process of the instant berberine preparation is performed by two steps of synthesizing high-hydrophilia negative-charge-rich polyacrylic resin with a coating function, which is called as a negative-electricity hydrophilic resin; fully mixing the berberine and the negative-electricity hydrophilic resin to obtain a yellow cream, namely the instant berberine cream. The negative-electricity resin is suitable for preparing the instant berberine, and also other low-solubility organic pharmaceutical molecules. The synthesized instant berberine cream can be further dried and smashed to obtain instant berberine powder. The instant berberine cream and the instant berberine powder can be mixed and dissolved in water according to any proportion. The instant berberine can be used for preparing a sterilization agent and a harmful blue-green algae inhibiting agent.

Description

technical field [0001] The invention relates to the field of medicine, specifically, an instant berberine preparation which can obviously improve the solubility of berberine in a simple, safe and effective way, and a preparation method and application thereof. Background technique [0002] Berberine is a broad-spectrum bactericidal and anti-inflammatory drug, which can also be used for the treatment of water environment, such as inhibiting and killing Microcystis aeruginosa. However, berberine usually exists in the form of berberine hydrochloride, and its solubility in water is no more than 0.2%, which greatly affects the application of berberine and the full exertion of drug potency. For this reason, various efforts have been made to increase the solubility of berberine. For example, berberine is emulsified with commonly used emulsifiers and emulsification aids, but the amount of emulsifier used is much higher than that of berberine, and its solubility generally can only r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/90A01N25/14A01N25/10A01P1/00A01P13/00
Inventor 张树林丛方地毕相东陈叶巧
Owner TIANJIN AGRICULTURE COLLEGE
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