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Application of panax japonicus IV a in prevention and treatment of cardiovascular disease and complication of cardiovascular disease

A technology for the prevention and treatment of cardiovascular diseases and complications, which is applied in medicine. In the field of medicine, bamboo ginseng saponin Ⅳa can solve problems such as prevention and treatment effects that have not yet been discovered.

Inactive Publication Date: 2015-03-25
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report about the prevention and treatment effect of bamboo ginseng saponin Ⅳa on cardiovascular disease and its complications

Method used

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  • Application of panax japonicus IV a in prevention and treatment of cardiovascular disease and complication of cardiovascular disease
  • Application of panax japonicus IV a in prevention and treatment of cardiovascular disease and complication of cardiovascular disease
  • Application of panax japonicus IV a in prevention and treatment of cardiovascular disease and complication of cardiovascular disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Protective effect of different dosage groups of bamboo ginseng saponin Ⅳa on MI / RI in mice

[0018] (1) Test material

[0019] 1) Experimental animals

[0020] Thirty healthy C57 mice, weighing 20-22 g, were purchased from the Animal Center of Fourth Military Medical University. Animals were housed in separate cages (ambient temperature 24°C, humidity 60%-70%), fasted 1 h before surgery, and had free access to water.

[0021] 2) Main medicines and reagents

[0022] Bamboo ginseng saponin Ⅳa, specification 3g (Chengdu Pufeide Biotechnology Co., Ltd., CAS number: 51415-02-2, purity ≥ 98%); lactate dehydrogenase LDH and Coomassie brilliant blue protein quantitative kit (Nanjing Jiancheng Biotechnology Co., Ltd. Engineering Institute); CK-MB, cTnI kit (Mannheim, Germany); 2,3,5-triphenyltetrazolium chloride (TTC) stain (Sigma-Aldrich, USA, T8877); Evans blue (EB) stain (US Sigma-Aldrich Company, E2129).

[0023] 3) Main instruments

[0024] HX-100E small ...

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Abstract

The invention relates to application of panax japonicus IV a in prevention and treatment of cardiovascular disease and complication of the cardiovascular disease. Experiments show that the panax japonicus IV a has obvious protection effect on ischemia / reperfusion C57 mouse myocardium, the optimum dose is determined, and a medicine for preventing and treating the cardiovascular disease and related complication of the cardiovascular disease can be further prepared.

Description

technical field [0001] The invention relates to a new application of bamboo ginseng saponin IVa in the field of medicine, specifically refers to the application of bamboo joint ginseng saponin IVa in preventing and treating cardiovascular diseases and their complications, and belongs to the technical field of medicine. Background technique [0002] Coronary heart disease has become a major disease affecting human health, and it is also one of the diseases with the highest mortality rate in the world. According to the report of the World Health Organization in 2011, the number of deaths from coronary heart disease in China ranks second in the world. At the same time, the "China Cardiovascular Disease Report 2012" released by the National Center for Cardiovascular Diseases pointed out that the number of patients with cardiovascular diseases in my country is 290 million, and one person dies of cardiovascular diseases every 10 seconds. Unhealthy living habits such as unreasonab...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P9/06A61P9/00A61P9/10A61P29/00A61P7/08A61P7/00
CPCA61K31/704
Inventor 奚苗苗殷英段佳林闫佳佳牟菲郭超翁琰关月朱艳荣卫国王艳华
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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