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Pharmaceutical composition for preventing and/or treating allergic rhinitis and allergic asthma

A composition and drug technology, which can be used in drug combinations, allergic diseases, pharmaceutical formulations, etc., can solve the problems of large side effects, easy recurrence, and long course of treatment for allergic rhinitis.

Active Publication Date: 2015-03-25
吉林一正药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in the long-term application, it is found that the above-mentioned medicines have the following disadvantages: 1. The side effects are large, and many antihistamines and hormone drugs will cause sleepiness and fatigue. In addition, liver and kidney damages are also caused, and severe cases will also cause obesity, infection, Pigmentation etc.
2. Recurrent attacks, treating the symptoms but not the root cause
Traditional Chinese medicine treatment of allergic rhinitis mostly takes a long course of treatment, the curative effect is not exact, and it is easy to relapse

Method used

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  • Pharmaceutical composition for preventing and/or treating allergic rhinitis and allergic asthma
  • Pharmaceutical composition for preventing and/or treating allergic rhinitis and allergic asthma
  • Pharmaceutical composition for preventing and/or treating allergic rhinitis and allergic asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1. Preparation of granules of traditional Chinese medicine composition

[0044] Take 75g astragalus, 60g white peony root, 50g cinnamon sticks, 50g ginger, 50g bitter almonds, 30g fenfeng, 15g cicada slough, 30g orange, 70g jujube (with nucleus) and 50g licorice (honey roasted) Shiweijing medicinal materials, The above-mentioned medicinal materials were decocted and extracted twice with water. The amount of water added was 8 times and 6 times of the total mass of the medicinal materials. The extraction time was 3 hours and 2 hours respectively. After each extraction, it was filtered and the combined filtrate was concentrated to a relative density of 1.10 (measured at 70℃) of the clear ointment, let it cool, add 80% (volume percentage) of ethanol to make the alcohol content 50% (volume percentage), stir well, let stand for 48 hours, and take the supernatant Recover ethanol to the end, concentrate the liquid medicine to a thick paste with a relative density of 1.20 (...

Embodiment 2

[0045] Example 2. Preparation of capsules of traditional Chinese medicine composition

[0046] Take 150g of astragalus, 120g of white peony root, 100g of cinnamon sticks, 100g of ginger, 100g of bitter almonds, 60g of windbreak, 30g of cicada slough, 60g of orange, 140g of jujube (with nucleus), and 100g of licorice (honey roasted). Add water 10 times the total mass of the above medicinal materials, decoct and extract for 3 hours, after the extraction is complete, filter, the filtrate is concentrated to a clear ointment with a relative density of 1.15 (measured at 70℃), let cool, and add 90% (volume) Percentage) of ethanol to make the alcohol content reach 60% (volume percentage), stir well, let stand for 24 hours, take the supernatant to recover the ethanol to the end, and concentrate the drug solution to a relative density of 1.25 (measured at 70°C) The thick paste is dried, crushed, passed through an 80-120 mesh sieve, and 0.08 times the mass of the obtained powdered starch an...

Embodiment 3

[0047] Example 3. Preparation of capsules of traditional Chinese medicine composition

[0048] Take 120g astragalus, 20g white peony root, 80g cassia twig, 20g ginger, 80g bitter almonds, 10g fenfeng, 24g cicada slough, 12g orange, 115g jujube (with nucleus) and 20g licorice (honey roasted) Shiweijing medicinal materials, The above-mentioned medicinal materials were decocted and extracted twice. The amount of water added was 8 and 6 times the mass of the medicinal materials. The extraction time was 3 hours and 2 hours respectively. After each extraction, it was filtered and the combined filtrate was concentrated to a relative density of 1.15. (Measured at 70℃), let it cool, add 70% (volume percentage) of ethanol to make the alcohol content reach 40% (volume percentage), stir well, stand for 12 hours, take the supernatant for recovery After the ethanol is exhausted, the medicinal solution is concentrated to a thick paste with a relative density of 1.35 (measured at 70°C), dried, c...

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Abstract

The invention discloses a pharmaceutical composition for preventing and / or treating allergic diseases and preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared from raw materials including, by weight, 6-24 parts of astragalus, 4-20 parts of white peony root, 4-16 parts of cassia twig, 4-16 parts of fresh ginger, 4-16 parts of almond, 2-10 parts of radix sileris, 1.2-4.8 parts of cicada slough, 2.4-9.6 parts of reddish orange, 5-23 parts of jujubes (without kernels) and 4-16 parts of liquorice. The preparation method includes the steps: weighing the astragalus, the white peony root, the cassia twig, the fresh ginger, the almond, the radix sileris, the cicada slough, the reddish orange, the jujubes and the liquorice in proportion; extracting medicinal materials with water; filtering and collecting filtrate; concentrating the filtrate into extract with the relative density of 1.05-1.25 to obtain the pharmaceutical composition. The pharmaceutical composition is used for treating allergic rhinitis and allergic asthma and has the advantages of remarkable curative effect, convenience in use, rapidness in starting effects, safety, no pain and the like.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for preventing and / or treating allergic rhinitis and allergic asthma. Background technique [0002] Allergic diseases, also called allergic diseases, are currently the most common type of chronic diseases. It is manifested as the human body produces an excessively strong immune response to one or more substances in the environment, and causes tissue and organ damage, thereby affecting normal physiological functions. Allergic diseases have a natural process of gradual deterioration, involving more tissues and organs, and other diseases and even life-threatening. Common allergic diseases include allergic rhinitis and allergic asthma. [0003] Allergic rhinitis, or allergic rhinitis (AR), refers to the release of IgE-mediated mediators (mainly histamine) after exposure to allergens by atopic individuals, and there are a variety of immunologically active cells and cells Non-infectious inflammatory diseases ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P11/02A61P11/06A61P37/08A61K35/64
CPCA61K9/1652A61K9/2059A61K9/4866A61K35/63A61K36/238A61K36/481A61K36/484A61K36/54A61K36/71A61K36/725A61K36/736A61K36/752A61K36/9068A61K2236/333A61K2236/39A61K2300/00
Inventor 于春江
Owner 吉林一正药业集团有限公司
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