Registration and fusion method for small-animal multi-modal medical images

A technology of medical imaging and fusion methods, applied in image enhancement, image analysis, image data processing and other directions, can solve the problems of high operation process requirements, large amount of fusion calculation, and unsatisfactory fusion effect.

Active Publication Date: 2015-04-08
SOUTHEAST UNIV
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Problems solved by technology

[0005] The purpose of the present invention is to provide a small animal multi-modal medical image registration and image fusion method, which solves the problems in the prior art that the in vitro marker points are difficult to mark and make, the operation process requires high requirements, the fusion calculation amount is large, and the fusion effect is low. Unsatisfactory and other defects

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  • Registration and fusion method for small-animal multi-modal medical images
  • Registration and fusion method for small-animal multi-modal medical images
  • Registration and fusion method for small-animal multi-modal medical images

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Embodiment

[0042] The technical solution of the present invention is a method for registration and fusion of multimodal medical images of small animals, which can realize the fusion of images of two or more medical imaging devices. In this example, a representative small animal PET / CT image fusion is selected as an example. The specific implementation scheme can be divided into the design of the small animal bed, the experimental operation process, the image fusion algorithm and the fusion image display method.

[0043] The fixing scheme of the small animal bed on the stage is as follows: figure 1 . The stage is made of carbon fiber material (length 900mm, arc R59), the stage can easily move freely between small animal PET and small animal CT. There are two threaded holes on the bottom of the small animal bed, which can be fixed with the bottom of the stage. Two metal clips are also used to further ensure the relative stability between the small animal bed and the stage.

[0044] The...

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Abstract

The invention discloses a registration and fusion method for small-animal multi-modal medical images and belongs to the field of image processing. According to the method, an in-vitro marking method is adopted, two crossed tubes injected with mixed developers are fixedly arranged on the outer side of a small-animal bed and serve as in-vitro markers, a reference coordinate system ORef is established between two or more pieces of medical image equipment, and images acquired by different pieces of medical image equipment are fused through a common reference coordinate system. The fusion process is free from manual intervention. The method is simple, the small-animal multi-modal medical images can be registered and fused, and richer information is provided for the images acquired by the independent medical image equipment.

Description

technical field [0001] The invention belongs to the technical field of image registration and fusion of multimodal medical equipment, and in particular relates to an independent clinical or experimental small animal multimodal medical image registration and image fusion method. Background technique [0002] At present, multi-modal medical imaging is mainly used in clinical work for diseases such as tumors, cardiovascular system, and nervous system. In the process of scientists' understanding and research of a certain disease, the establishment of animal models is very important for understanding disease-related diseases. The pathogenesis, evolution process, and new drug development and efficacy monitoring in the therapeutic field all play an irreplaceable role. Therefore, the research of multimodal medical imaging in the field of small animals is also gradually carried out. [0003] However, special-purpose small animal multimodal medical imaging equipment is expensive, and ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/00
CPCG06T7/38G06T2207/10016G06T2207/10081G06T2207/10104G06T2207/30004
Inventor 罗守华杨晶李光顾宁
Owner SOUTHEAST UNIV
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