Compounds having magnetic functionality, implants or gels derived from same, and use of both in order to determine the enzyme activity of an enzyme

A technology of magnetic functionality and compounds, applied in measuring devices, biological testing, microbial measurement/inspection, etc., can solve problems such as loss of strength, accuracy of enzyme activity, object persistence, etc.

Inactive Publication Date: 2015-04-22
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since this breakdown is the result of a cascade of activation of pre-implanted enzyme precursors rather than the target enzyme, this method loses the precision of the intensity and persistence of the studied enzymatically active objects.

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  • Compounds having magnetic functionality, implants or gels derived from same, and use of both in order to determine the enzyme activity of an enzyme
  • Compounds having magnetic functionality, implants or gels derived from same, and use of both in order to determine the enzyme activity of an enzyme
  • Compounds having magnetic functionality, implants or gels derived from same, and use of both in order to determine the enzyme activity of an enzyme

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Embodiment Construction

[0037] Among other principles, the present invention exploits the fact that the properties of a magnetic material derive from the distribution and shape of its constituents. If either of these two characteristics can be altered by enzymatic activity, it can be detected based on the measurement of magnetic properties. The format in which this assay is performed stimulates particle aggregation as a result of enzymatic activity. In order to first understand the role of magnetic particle aggregations, a general description of the properties of the different types of magnetic materials from which they can be formed is given.

[0038] Ferromagnetic materials generally contain transition metals such as iron (Fe), magnesium (Mg), manganese (Mn), cobalt (Co), nickel (Ni), zinc (Zn), and copper (Cu). Ferromagnetic materials are also characterized in that they consist of about 10 17 to 10 21 Groups of atoms are formed that all have magnetic moments (or spin populations) pointing in th...

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Abstract

The invention relates to an implant or gel including at least one compound having magnetic functionality, which in turn includes a substrate of at least one enzyme involved in regenerating the extracellular matrix and a plurality of magnetic particles. The invention also relates to a compound having magnetic functionality which includes a substrate of at least one enzyme involved in regenerating the extracellular matrix and a plurality of magnetic particles, preferably with no coating or surface modification, or functionalised with carboxyl groups, for the production of an implant or gel for monitoring an enzymatic activity involved in regenerating the extracellular matrix. The substrate is preferably selected from the group that comprises collagen, chondroitin sulphate and hyaluronic acid, and the magnetic particles are superparamagnetic particles.

Description

field of invention [0001] The present invention generally relates to implants or gels comprising at least one magnetically functional compound. These implants or gels can be used to measure changes in the magnetic properties of at least one magnetically functional compound, one or more of its degradation products, or both. of enzyme activity. [0002] In addition, the present invention also relates to novel compounds with magnetic functionality, which comprise a substrate for at least one enzyme, preferably collagen, chondroitin sulfate or hyaluronic acid, and which have no coating or surface modification, or have carboxylic acid groups Functionalized Multiple Magnetic Particles. Background of the invention [0003] Enzymes are proteins that catalyze chemical reactions. In an enzymatic reaction, the molecule on which the enzyme acts is called a substrate, and said molecule is converted by the enzyme into different molecules called metabolites. Enzymes are usually very sp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/14A61K49/18G01N33/53
CPCA61K49/1863G01N2800/10A61K49/1866G01N33/54326C12Q1/26C12Q1/34C12Q1/37A61K49/14A61K49/18G01N33/53A61K49/085A61K49/12A61K49/1821
Inventor 马里塞拉·贝莱斯·蒂拉多胡利安·戴希
Owner CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
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