A biological hard tissue replacement and repair material and its preparation method

Abstract

The invention relates to the technical field of biological bone conduction and bone repair material, and discloses a hard biotissue replacement and repair material and a preparation method thereof. The hard biotissue replacement and repair material comprises the following components in parts by mass: 1-25 parts of nano-hydroxyapatite, 100 parts of polymethyl methacrylate, 1-25 parts of polylactic acid, 0.25-0.35 part of initiator, and 0.16-4.31 parts of coupling agents. The preparation method comprises the following steps: dispersing a precursor calcium nitrate and diammonium hydrogen phosphate generating hydroxyapatite into methyl methacrylate monomer and lecithin mixed solution, and performing in-situ precipitation of the hydroxyapatite and in-situ polymerization of polymethyl methacrylate simultaneously, to generate a prepolymer; then performing blend polymerization on polylactic acid and the prepolymer, to generate a ternary composite material; and finally injecting into a mold and carrying out vacuum heating and curing, and processing and forming. The composite material is good in phase interface bonding, inorganic nanoparticles have small particle size and are evenly dispersed, and the composite material is an artificial bone composite material with excellent performances.

Description

technical field [0001] The invention relates to the technical field of preparation of biomedical bone conduction and bone repair materials. Background technique [0002] The demand for bone defect and bone substitute materials in the world is growing rapidly at an annual rate of 10.3%, and artificial synthesis of bone defect and bone substitute materials has become an inevitable choice for modern medicine. Among them, hydroxyapatite (HA), polymethyl methacrylate (PMMA), and polylactic acid (PLA) are used in large amounts. [0003] In the selection of raw materials, the structure and composition of hydroxyapatite (HA) are very similar to those of natural bone. It is the main component of the inorganic matter of human hard tissue and can form a firm biological bond with bone tissue. However, due to the high brittleness of hydroxyapatite, it cannot be used alone as a load-bearing bone. Polymethyl methacrylate (PMMA) is one of the earliest medical polymer materials, which is c...

AI Technical Summary

Problems solved by technology

The blending method is to compound inorganic nanoparticles and polymers according to different processes. It is currently the most commonly used method for preparing polymer nanocomposites. Its advantage is that the preparation of nanoparticles and the synthesis of polymers are carried out separately, and the nanoparticle The size and shape of the particles; the disadvantage is that the nanoparticles are prone to agglomeration, and it is not easy to achieve uniform dispersion of the nanoparticles during blending, resulting in inhomogeneous product properties, poor interface bonding, and severe constraints on the interface compatibility and bonding degree between different phases Its performance leads to unstable mechanical and chemical properties of the material, such as uneven distribution of hydroxyapatite in the matrix, resulting in uneven material structure, different strength, elastic modulus, specific density, etc. of different parts, bone repair materials and Poor stability of bone biobonding

At the same time, these methods all have the problems of long time consumption and complicated synthesis conditions.

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