A fast microchannel pressure measurement device based on capillary

Abstract

The invention discloses a quick micro-channel pressure measuring device based on a capillary. A main channel and a pressure measuring branch are machined on the lower wall surface of a PDMS microchip with a soft photolithography, one end of the pressure measuring branch is opened in a position, where pressure measurement is required, in the main channel, the other end (back end) of the pressure measuring branch is connected with the capillary, one end I of the capillary is closed, the other end II of the capillary is inserted in the back end of the pressure measuring branch, the end II and the back end are sealed by glass cement, and the upper wall surface of a glass substrate is bonded to the lower wall surface of the PDMS microchip after subjected to plasma treatment. The device has the novelty that a new method for measuring the pressure in a micro-channel is designed. The structure of the micro-channel can be designed by oneself, and the length of the capillary can also be selected by oneself, so that different pressure measuring ranges can be met.

Description

technical field [0001] The invention aims at the flow path pressure in the microfluidic chip, and belongs to the technical field of rapidly measuring the pressure in the microchannel by using an experimental device. Background technique [0002] Since A.Manz proposed the micro-total analysis system (μ-TAS) in the 1990s, it has developed into one of the most cutting-edge technological fields in the world in just a decade, and has also rapidly promoted the development of micro-electronic machinery. So far, MEMS has been widely used in many fields such as micromechanical component manufacturing, information, automobile industry, biomedical engineering, aerospace, national defense and military. As an important branch of MEMS, microfluidic systems are widely used in the fields of cytology, biochemistry, and pharmacy due to their characteristics of controllable liquid flow, minimal consumption of samples and reagents, and increased analysis speed by ten or hundreds of times. , ch...

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Problems solved by technology

[0003] In fact, the existing methods for pressure measurement and control of microfluidic systems still have certain difficulties. On the one hand, at the microscale, the flow characteristics of microfluids will produce a "size effect" that is different from that under macroscopic conditions. ", which will cause the traditional pressure measurement methods and theoretical models to be no longer suitable for microfluidic systems because they cannot accurately reflect the flow changes in microscale flow paths.

On the other hand, at this stage, the pressure measurement methods of microfluidic systems have their own limitations. Most of the pressure measurement methods in microfluidics at this stage use pressure sensors such as laser displacement sensors outside the microfluidic system. , micro piezoelectric sensors, etc., but this method also has certain disadvantages: 1. It is necessary to add a complex external pressure measuring device outside the microfluidic system, which is difficult to implement, complicated to operate, expensive in equipment, and long in response time; 2. Unable to Realize the measurement of the pressure at any position of the microfluidic chip; 3. The traditional method of placing a pressure sensor outside the chip has a certain pressure dissipation during the measurement process, resulting in inaccurate measured pressure

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