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Method for synthesizing eriocitrin from hesperidin

A technology of eriocitrin and hesperidin, which is applied in the field of synthesizing eriocitrin by using hesperidin, can solve the problems of cumbersome process, failure to meet market demand, high cost, etc., achieve simple process, balance cost and benefit, avoid Effects of damage and loss

Active Publication Date: 2015-05-13
MIANYANG DIAO PHARMA
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to provide a method for synthesizing eriocitrin by using hesperidin, which mainly solves the problems that existing methods for obtaining eriocitrin have cumbersome processes, high costs, and cannot meet market demand

Method used

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Embodiment

[0030] The invention provides a method for producing eriocitrin, which mainly consists of the following processes.

[0031] First, hesperidin is added to a mixed solvent composed of an alkaline solvent and a halide catalyst to dissolve and react. Among them, the alkaline solvent plays the role of dissolving hesperidin, and thiol, dimethyl Solvents such as formamide, piperidine, pyridine, dimethyl sulfoxide or dioxane solvent, and the halide catalyst reacts with the dissolved hesperidin to remove the methyl group in the hesperidin. The halide catalyst can be used Catalysts such as fluoride, chloride, bromide or iodide. In the above process, the contents of hesperidin, alkaline solvent and halide catalyst are respectively 90-110kg, 300-1000L and 0.3-1kg, and the reaction temperature is 60-120°C, and the reaction time is 15-24h.

[0032] After the reaction is completed, the solution after the reaction is collected, and at the same time, all the alkaline solvents that do not part...

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Abstract

The invention discloses a method for synthesizing eriocitrin from hesperidin. The method comprises steps as follows: (1) adding the hesperidin to a mixed solution consisting of a basic solvent and a halide catalyst for reactions; (2) recovering the basic solvent, then adding an acid sulfide or acid halide aqueous solution to the solution with the basic solvent recovered, and performing heating and stirring for hydrolysis; (3) filtering the solution after hydrolysis, and decolorizing a filtrate with decolorizing resin to obtain a decolorized solution; (4) performing chromatographic separation on the decolorized solution, and eluting the solution with ethanol; (5) concentrating the eluent; (6) dissolving and refining the concentrated eluent with ethanol, and performing filtration; (7) recovering the ethanol from the filtrate to obtain paste, and then drying the paste to obtain a finished product with the eriocitrin content ranging from 80% to 98%. According to the method, the eriocitrin is synthesized from the hesperidin used as a raw material, processes are simplified, the cost is reduced, both the yield and the quality are guaranteed, and market demands are substantially satisfied.

Description

technical field [0001] The invention relates to a synthesis method, which belongs to the technical field of raw material processing and extraction, and specifically relates to a method for synthesizing eriocitrin by using hesperidin. Background technique [0002] Eriocitrin, also known as lemon flavonoid, molecular formula C 27 h 32 o 15 , which is a compound substance present in the fruit, young fruit and skin of Citrus fruit trees of the Rutaceae Citrus subfamily, which needs to be obtained by extraction and processing technology. Eriocitrin not only has a strong antioxidant effect, but also can inhibit the oxidative stress injury induced by acute exercise in rat liver, reduce blood lipids, and the antioxidant capacity of eriocitrin is stronger than that of hesperidin and naringin etc. Therefore, it is commonly used in industries such as beverages, food and wine antioxidants, dietary supplements and medicine. [0003] At present, in industrialized use, it is genera...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/00
Inventor 牟成太江波周传武肖光明陈琼冯远志牟成坤
Owner MIANYANG DIAO PHARMA
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