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Anticancer pharmaceutical composition and its preparation method and application

A composition and drug technology, applied in the field of medicine, can solve the problems of unsatisfactory treatment effect, death, organ damage and the like

Active Publication Date: 2016-10-19
张苑金
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, tumor chemotherapy has made great progress, but the treatment effect on solid tumors, which is the most serious threat to human life and health and accounts for more than 90% of malignant tumors; At the same time, it will inevitably cause damage or toxicity to normal tissues and organs, bring pain to patients, and even lead to death

Method used

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  • Anticancer pharmaceutical composition and its preparation method and application
  • Anticancer pharmaceutical composition and its preparation method and application
  • Anticancer pharmaceutical composition and its preparation method and application

Examples

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specific Embodiment

[0024] According to other specific embodiments of the present invention, the pharmaceutically acceptable salt of 9-methoxycamptothecin can be selected from hydrochloride, sulfate, acetate, benzoate, fumarate, horse Tonate, citrate, 2,5-dihydroxybenzoate, methanesulfonate, ethanesulfonate, benzenesulfonate, p-toluenesulfonate, laurylsulfonate, hydroquinonesulfonic acid Any of salt and hydrobromide. Thus, the salt of 9-methoxycamptothecin in the embodiment of the present invention is relatively stable, and can be compatible with another active ingredient camptothecin or a pharmaceutically acceptable salt thereof in the pharmaceutical composition of the embodiment of the present invention Together they form a pharmaceutical composition that can effectively treat or prevent cancer.

[0025] According to the embodiments of the present invention, the ratio of camptothecin to 9-methoxycamptothecin is not particularly limited, as long as it can effectively treat cancer animal models ...

Embodiment 1

[0063] Embodiment 1 extracts camptothecin

[0064] Use 8 times the weight of 60% ethanol to heat and reflux extract the leaves of schimabi wood for 3 times, each time for 1.5 hours, filter and combine to obtain the stinky babi wood alcohol extract; concentrate the skunk babi wood alcohol extract to obtain Smell concentrated solution; Utilizing hydrochloric acid to adjust the pH of the Smudge concentrate until the pH of Smash concentrate is 5; then using ethyl acetate to extract 3 Second, combine the extraction phases to obtain camptothecin crude extract; add 70% acetone aqueous solution to the obtained camptothecin crude extract, stir evenly and stand still for 20 hours to carry out suction filtration to obtain the first filter cake and the second filter cake. One filtrate; add 3 times volume ratio of 1:20 fatty alcohol and methyl chloride mixture to a part of the first filter cake, stir evenly and stand still for 10 hours to carry out suction filtration, thereby obtaining the...

Embodiment 2

[0065] Embodiment 2 extracts 9-methoxycamptothecin

[0066]Obtain the first 9-methoxycamptothecin crude product after reclaiming the solvent in the first filtrate obtained in Example 1; In another part of the first filter cake, add 5 times the amount of fatty alcohol with a volume ratio of 1:20 Ethyl acetate, after stirring evenly, stand still for 10 hours and carry out suction filtration, thereby obtain the 3rd filter cake and the 3rd filtrate, obtain the second 9-methoxycamptothecin crude product after reclaiming the solvent in the 3rd filtrate; Then obtain The first 9-methoxycamptothecin crude product and the second 9-methoxycamptothecin crude product are combined, and the combined 9-methoxycamptothecin crude product is purified by using a cation exchange resin to finally obtain 9 - Methoxycamptothecin.

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Abstract

Provided are an anticancer pharmaceutical composition, a preparation method for same, and a use thereof. The pharmaceutical composition comprises camptothecin or a pharmaceutically acceptable salt thereof, 9-methoxy camptothecin or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

Description

[0001] priority information [0002] none. technical field [0003] The invention relates to the field of medicine, in particular to an anticancer pharmaceutical composition and its preparation method and application. Background technique [0004] Cancer is one of the diseases that seriously affect human health and threaten human life in the world. It ranks among the top three causes of death in all countries in the world and is the second leading cause of death in my country after cardiovascular disease. In recent years, tumor chemotherapy has made great progress, but the treatment effect on solid tumors, which is the most serious threat to human life and health and accounts for more than 90% of malignant tumors; At the same time, it will inevitably cause damage or toxicity to normal tissues and organs, bring pain to patients, and even lead to death. Therefore, the development and research of new and effective anti-tumor drugs is a major topic and long-term task in the fi...

Claims

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Application Information

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IPC IPC(8): A61K31/4745A61K9/14A61K9/20A61K9/48A61K9/06A61K9/12A61K9/70A61K9/08A61K9/52A61P35/00
CPCA61K9/08A61K9/12A61K9/1652A61K9/2054A61K9/4866A61K9/7069A61K31/4745A61K36/22A61K47/10A61P35/00
Inventor 张苑金张明杰
Owner 张苑金
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