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Nipple sealing agent for preventing mastitis of cows in dry period and preparation method thereof

A teat sealant and a technology for dry milk period, applied in the field of a teat sealant for preventing dry milk cow mastitis and its preparation field, can solve the problems of breast fever and pain, increase in milk somatic cells, and the cure rate, so as to improve the cure rate, Good therapeutic effect, relieve inflammation effect

Active Publication Date: 2015-05-27
QILU ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problem that the existing teat sealant combined with antibiotics causes inflammatory pathological reactions such as breast heat and pain, swelling, and increased milk somatic cells and has a low cure rate, the present invention provides a method for preventing mastitis in the dry period of dairy cows. Teat sealant and method for its preparation

Method used

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  • Nipple sealing agent for preventing mastitis of cows in dry period and preparation method thereof
  • Nipple sealing agent for preventing mastitis of cows in dry period and preparation method thereof
  • Nipple sealing agent for preventing mastitis of cows in dry period and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1) Micronize bismuth subnitrate and geniposide separately, until the particle size is not greater than 25 microns (μm);

[0026] 2) Put 26.43g of liquid paraffin into a 250ml beaker, raise the temperature to 140°C, add 2.5g of aluminum stearate, 1.0g of silicon dioxide, 0.05g of 2,6-di-tert-butyl-p-cresol, and o-phenyl Phenol 0.02g, heated and stirred until completely dissolved to make it into a gel matrix, and cooled in a cold water bath to below 40°C;

[0027] 3) Take 5.0 g of the geniposide treated with micronization in step 1) and place it in the gel matrix, disperse it by ultrasonic, and homogenize it in a high-shear dispersing homogenizer for 10 minutes;

[0028] 4) Add 20.0g bismuth subnitrate in batches, add 2.0g in each batch, stir while adding, continue stirring for 20min after adding the 20.0g bismuth subnitrate; then add 45.0g bismuth subnitrate in batches, each time Add 2.0g, stir while adding, and continue stirring for 20 minutes after the addition is com...

Embodiment 2

[0031] 1) Micronize bismuth subnitrate and geniposide separately, until the particle size is not greater than 25 microns (μm);

[0032] 2) Put 39.93g of liquid paraffin into a 250ml beaker, raise the temperature to 140°C, add 4.0g of aluminum stearate, 1.0g of silicon dioxide, 0.05g of 2,6-di-tert-butyl-p-cresol, and o-phenyl Phenol 0.02g, heated and stirred until completely dissolved to make it into a gel matrix, and cooled in a cold water bath to below 40°C;

[0033] 3) Take 5.0 g of the geniposide treated with micronization in step 1) and place it in the gel matrix, disperse it by ultrasonic, and homogenize it in a high-shear dispersing homogenizer for 10 minutes;

[0034] 4) Add 15.0g bismuth subnitrate in batches, add 1.5g in each batch, stir while adding, continue stirring for 20min after adding the 15.0g bismuth subnitrate; then add 35.0g bismuth subnitrate in batches, each time Add 2.0g, stir while adding, and continue stirring for 20 minutes after the addition is com...

Embodiment 3

[0037] 1) Micronize bismuth subnitrate and geniposide separately, until the particle size is not greater than 25 microns (μm);

[0038] 2) Put 17.43g of liquid paraffin into a 250ml beaker, raise the temperature to 140°C, add 1.5g of aluminum stearate, 1.0g of silicon dioxide, 0.05g of 2,6-di-tert-butyl-p-cresol, and o-phenyl Phenol 0.02g, heated and stirred until completely dissolved to make it into a gel matrix, and cooled in a cold water bath to below 40°C;

[0039] 3) Take 5.0 g of the geniposide treated with micronization in step 1) and place it in the gel matrix, disperse it by ultrasonic, and homogenize it in a high-shear dispersing homogenizer for 10 minutes;

[0040] 4) Add 25.0g bismuth subnitrate in batches, add 2.5g in each batch, stir while adding, continue stirring for 20min after adding the 25.0g bismuth subnitrate; then add 50.0g bismuth subnitrate in batches, each time Add 2.5g, stir while adding, and keep stirring for 20 minutes after the addition is complet...

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Abstract

The invention discloses a nipple sealing agent for preventing mastitis of cows in a dry period and a preparation method thereof, and belongs to the field of veterinary medicines. The nipple sealing agent consists of the following components in percentage by weight: 40-75wt% of a non-toxic metal compound, 2-10wt% of geniposide and 10-50wt% of a gel matrix, wherein the gel matrix consists of the following components in percentage by weight: 70-90wt% of a dispersion medium, 5-12wt% of gels, 2-5wt% of a suspending agent, 0.1-0.3wt% of an antioxidant and 0.04-0.15wt% of a preservative. According to the nipple sealing agent disclosed by the invention, effective components namely geniposide and the non-toxic metal compound are matched with each other to ensure that the nipple sealing agent has high cure rate on mastitis of the cows in the dry period and can be used for effectively reliving the inflammatory reaction of clinical mastitis.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a teat sealant for preventing dry mastitis in dairy cows and a preparation method thereof. Background technique [0002] Mastitis is a common and frequently-occurring disease of dairy cows and one of the most important diseases affecting the development of the dairy industry. It not only reduces the amount of milk produced and the quality of dairy products, but even causes damage to the udder, causing huge economic losses to the dairy industry. At present, there are about 220 million dairy cows in the world, 1 / 3 of which suffer from various types of mastitis, and the annual loss due to mastitis is as high as 35 billion U.S. dollars, and the loss in the United States alone reaches 2 billion U.S. dollars. According to 30 years of investigation and research data, the average detection rate of mastitis in dairy cows in my country is 50% to 70%, and the average positive ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/30A61K33/24A61K31/7048A61K9/06A61P15/14A61P31/04
Inventor 王海挺张智德刘金华孔梅吴连勇王甜
Owner QILU ANIMAL HEALTH PROD
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