Method for determining content of ferulic acid in pill

A ferulic acid and content technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve problems such as low quality, unstable drug quality, and no regulations on quality testing methods, and achieve stable and high quality effects

Inactive Publication Date: 2015-05-27
广西梧州三鹤药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] The existing drug standards were promulgated in the early 1990s. Although the standard inspection is simple and easy to control, there are no provisions in the standard on quality testing methods such as the content of active ingredients in drugs; Without distinguishing the inherent quality of medicinal materials, it is possible to easily manufacture finished pharmaceuticals that meet the original quality standards, but the quality of the prepared pharmaceuticals is not stable and the quality is not high

Method used

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  • Method for determining content of ferulic acid in pill
  • Method for determining content of ferulic acid in pill
  • Method for determining content of ferulic acid in pill

Examples

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Effect test

Embodiment 1

[0019] The method for determining the content of ferulic acid in pills, the instruments and reagents used: liquid chromatograph model: LC-20AD; chromatographic column: 4.6mm×250mm; ferulic acid reference substance: provided by the National Institute for the Control of Pharmaceutical and Biological Products ; Methanol is chromatographically pure, acetic acid is chromatographically pure;

[0020] The method includes the following specific steps:

[0021] A. Chromatographic conditions and system suitability test: octadecylsilane bonded silica gel is used as filler, methanol and 1% acetic acid are used as mobile phase at a volume ratio of 30:70, detection wavelength is 320nm, column temperature is room temperature, theoretically The number calculated based on the ferulic acid peak should not be less than 5000;

[0022] B. Preparation of reference substance solution: Take an appropriate amount of ferulic acid reference substance, accurately weigh it, and add methanol to make a solution...

Embodiment 2

[0026] The method for determining the content of ferulic acid in pills, the instruments and reagents used: liquid chromatograph model: LC-20AD; chromatographic column: 4.6mm×250mm; ferulic acid reference substance: provided by the National Institute for the Control of Pharmaceutical and Biological Products ; Methanol is chromatographically pure, acetic acid is chromatographically pure;

[0027] The method includes the following specific steps:

[0028] A. Chromatographic conditions and system suitability test: octadecylsilane bonded silica gel is used as filler, methanol and 1% acetic acid are used as mobile phase at a volume ratio of 30:70, detection wavelength is 320nm, column temperature is room temperature, theoretically The number calculated based on the ferulic acid peak should not be less than 5000;

[0029] B. Preparation of reference substance solution: Take an appropriate amount of ferulic acid reference substance, accurately weigh it, and add methanol to make a solution...

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Abstract

The invention discloses a method for determining the content of ferulic acid in a pill. The method takes ferulic acid as a reference substance and is used for determining the content of ferulic acid in the pill through high-performance liquid chromatography. On the basis of an existing drug standard, an inspection for determining the content of angelica in the finished pill is added, and the content of angelica is metered by that of ferulic acid. The content of ferulic acid in the pill is limited so as to achieve the aim of controlling the quality of the finished pill, so that the finished pill is stable and high in quality.

Description

Technical field [0001] The invention belongs to the technical field of drug quality control methods, and specifically relates to a method for determining the content of ferulic acid from pills. Background technique [0002] The current drug standard was promulgated in the early 1990s. Although the standard inspection is simple and easy to control, the standard does not contain provisions on quality testing methods such as the content of active ingredients in drugs; Without distinguishing the intrinsic quality of the medicinal materials, it is possible to easily manufacture finished medicines that meet the original quality standards, but the quality of the medicines produced is unstable and low in quality. [0003] Among them, the pills of the present invention are prepared with seven medicinal materials of Polygonum multiflorum 512g, dodder 128g, medlar 128g, achyranthes 128g, angelica 128g, poria 128g and psoralen 64 as a prescription; the above seven medicinal materials are crush...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 陈敏斐
Owner 广西梧州三鹤药业股份有限公司
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