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A self-guided diffuse optical tomography method for near-infrared optical brain function research

A tomography, brain function technology, applied in applications, medical science, telemetry patient monitoring, etc., can solve problems such as difficult algorithm for registration and fusion of multimodal measurement results of brain function, increased instrument costs, and difficulty in measurement operations. Achieve the effect of improving reconstruction speed and reducing underdetermination

Inactive Publication Date: 2017-03-01
TIANJIN UNIV
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Problems solved by technology

However, the brain function multimodal technology also has the obvious disadvantages of the simultaneous use of multiple measurement systems, which brings about the cost of equipment and the difficulty of measurement operations.
At the same time, the registration and fusion between the multimodal measurement results of brain function is quite difficult, which brings challenges to the algorithm

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  • A self-guided diffuse optical tomography method for near-infrared optical brain function research
  • A self-guided diffuse optical tomography method for near-infrared optical brain function research
  • A self-guided diffuse optical tomography method for near-infrared optical brain function research

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Embodiment Construction

[0031] The technical solutions of the present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments, and the described specific embodiments are only to illustrate the present invention, and are not intended to limit the present invention.

[0032] The present invention is used for the self-guided diffuse optical tomography method of near-infrared optical brain function research, and the specific steps are as follows:

[0033] For the predetermined detection area of ​​near-infrared brain functional imaging, it can be reasonably simplified as a two-layer flat model. The upper layer is the scalp and skull layer 10mm, and the lower layer is the gray matter layer 20mm. The detection method and source-detection distribution adopt the DOT high-density detection method. The shortest distance between two points is 10mm, and the source-detection points are arranged in a rectangular array. This embodiment is a 4×4 rectan...

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Abstract

The invention discloses a self-guidance diffused light tomography method for near-infrared brain function research. The self-guidance diffused light tomography method comprises the following steps: firstly, obtaining the light intensity of a detection point position corresponding to each source point; obtaining a two-dimensional topological image of which a detection area absorption coefficient is changed for the light intensity of the detection point position according to MLBL-OT, and performing image segmentation to achieve the effective positioning of an absorption coefficient change area, and generating an area positioning template matrix K; solving according to a DOT reconstruction method by adopting a Newton-Raphson iteration method, calculating a Jacobi matrix J of a node to obtain an OT-DOT reconstruction equation; calculating to obtain absorption coefficient change in predetermined detection, and drawing an OT-DOT reconstruction image. According to a near-infrared brain function self-guidance imaging method, the DOT inverse problem under-determinedness can be improved in a near-infrared optical modal measuring mode according to an MLBL-OT positioning brain function change area, so that the reconstruction speed is increased.

Description

technical field [0001] The invention belongs to a near-infrared brain function imaging method in biomedicine, in particular to a self-guided diffusion optical tomography method in near-infrared light brain function research. Background technique [0002] Human brain activity can lead to changes in blood flow and blood oxygen metabolism in the gray matter, and change the tissue optical parameters in the corresponding regions of the gray matter. Since human biological tissue absorbs less incident light with a wavelength in the range of 650-900nm, it can pass through the scalp and skull to reach the cerebral cortex. Near-infrared brain function research uses the incident light of near-infrared light in this band to carry out reflective measurement of the predetermined detection area of ​​the head in the resting state and brain activity state of the human body, and obtain the light field distribution at the scalp in the two states. Through the effective reconstruction of the ab...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00
CPCA61B5/0042A61B5/0082
Inventor 赵会娟刘明高峰贾梦宇戚彩霞
Owner TIANJIN UNIV
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