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Method for optimized extraction of total flavonoids of jasmine employing response surface method

A technology of response surface method and total flavonoids, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as difficult operation, long time, large solvent loss, etc., and achieve production safety and accelerated diffusion Effects of releasing and reducing danger

Active Publication Date: 2015-06-03
桂平市市场监督管理局
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing extraction method has complicated process, difficult operation, long time, high energy consumption, low yield, large solvent loss, environmental pollution and high product cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A method for optimizing the extraction of total flavonoids from jasmine by response surface methodology, the process steps are:

[0028] (1) Raw material crushing: crush the jasmine flower crusher;

[0029] (2) Impregnation: Put 50 kg of crushed jasmine into the extraction tank, then add 1000 kg of dimethyl carbonate solvent with a pH value of 6, and impregnate for 10 minutes;

[0030] (3) Extraction: after immersion, heat up to 85°C, start ultrasonic, control the frequency to 40 kHz, and control the time for 30 minutes, filter, re-extract the filter residue once, and combine the filtrate;

[0031] (4) Separation: put the combined filtrate of step (3) in a chromatographic tank for natural chromatography for 1 hour, then discharge the solvent and continue to use in the next batch of production;

[0032] (5) Purification: Add the extract of total flavonoids of jasmine separated in step (4) into a purification tank, continue natural chromatography, and filter to obtain th...

Embodiment 2

[0034] A method for optimizing the extraction of total flavonoids from jasmine by response surface methodology, the process steps are:

[0035] (1) Crushing of raw materials: crushing jasmine stems with a roller press;

[0036] (2) Impregnation: Put 50 kg of broken stems into the extraction tank, then add 750 kg of dimethyl carbonate solvent with a pH value of 5.5, and impregnate for 20 minutes;

[0037] (3) Extraction: After immersion, heat up to 92°C, start ultrasonic wave, control the frequency to 40 kHz, and control the time for 25 minutes, filter, re-extract the filter residue twice, and combine the filtrate;

[0038] (4) Separation: put the combined filtrate of step (3) into a chromatographic tank for natural chromatography for 0.8 hours, then discharge the solvent and continue to use it for the next batch of production;

[0039] (5) Purification: Add the extract of total flavonoids of jasmine separated in step (4) into a purification tank, continue natural chromatograp...

Embodiment 3

[0041] A method for optimizing the extraction of total flavonoids from jasmine by response surface methodology, the process steps are:

[0042] (1) Crushing of raw materials: crushing jasmine leaves with an extruder;

[0043] (2) Impregnation: Put 50 kg of broken jasmine leaves into the extraction tank, then add 900 kg of dimethyl carbonate solvent with a pH value of 5.8, and impregnate for 15 minutes;

[0044] (3) Extraction: After immersion, under the condition of raising the temperature to 90°C, start the ultrasonic wave, control the frequency to 48 kHz, and control the time for 20 minutes, filter, re-extract the filter residue once, and combine the filtrate;

[0045] (4) Separation: put the combined filtrate of step (3) in a chromatography tank for natural chromatography for 0.5 hours, and discharge the solvent to continue to be used in the next batch of production;

[0046] (5) Purification: Add the extract of total flavonoids of jasmine separated in step (4) into a purifi...

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Abstract

The invention discloses a method for optimized extraction of total flavonoids of jasmine employing a response surface method. The optimal extraction technology is determined by design expert software according to a Box-Behnken design as follows: the pH value of a solvent is 5.5-6; the liquid-to-solid ratio is (15-20) to 1; the raw materials are dipped for 10-20 minutes; the extraction temperature is 85-92 DEG C; the ultrasonic extraction time is 20-30 minutes; and the natural chromatography time is 0.5-1 hour. The solvent dimethyl carbonate is an environment-friendly solvent integrating cleanness and safety. Diffusion and release of a jasmine active component can be accelerated by cavatition and secondary effect of an ultrasonic wave; the jasmine active component can be fully mixed with a solvent; complete extraction is facilitated; and the yield of the product reaches 98.6%. The method is short in technological process, easy to operate, short in extraction time, low in solvent loss, energy-saving, and environmentally friendly; the product is high in yield and low in cost; the dangerousness in production is greatly reduced; and the method has relatively good economic benefits, social benefits and ecological benefits.

Description

technical field [0001] The invention relates to a method for extracting plants, in particular to a method for optimally extracting jasmine total flavonoids by response surface method, and belongs to the technical field of traditional Chinese medicines. Background technique [0002] The incidence of cardiovascular disease is increasing year by year in all countries in the world, and it has become the "number one killer" that threatens human health beyond cancer, and is the main cause of death of patients. According to WHO's statistics on the death of various diseases in the world, the number of deaths due to cardiovascular and cerebrovascular diseases accounts for about 30% of the total number of deaths, causing huge spiritual and economic burdens to the people and society. At present, the clinical treatment of ischemic heart disease such as hypertension and coronary heart disease is still based on drugs, including commonly used β receptor blockers, calcium antagonists, angi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/63
Inventor 黄锁义刘燕刘艳程世嘉潘乔丹黄上峰
Owner 桂平市市场监督管理局
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