Method for optimized extraction of total flavonoids of jasmine employing response surface method
A technology of response surface method and total flavonoids, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as difficult operation, long time, large solvent loss, etc., and achieve production safety and accelerated diffusion Effects of releasing and reducing danger
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Embodiment 1
[0027] A method for optimizing the extraction of total flavonoids from jasmine by response surface methodology, the process steps are:
[0028] (1) Raw material crushing: crush the jasmine flower crusher;
[0029] (2) Impregnation: Put 50 kg of crushed jasmine into the extraction tank, then add 1000 kg of dimethyl carbonate solvent with a pH value of 6, and impregnate for 10 minutes;
[0030] (3) Extraction: after immersion, heat up to 85°C, start ultrasonic, control the frequency to 40 kHz, and control the time for 30 minutes, filter, re-extract the filter residue once, and combine the filtrate;
[0031] (4) Separation: put the combined filtrate of step (3) in a chromatographic tank for natural chromatography for 1 hour, then discharge the solvent and continue to use in the next batch of production;
[0032] (5) Purification: Add the extract of total flavonoids of jasmine separated in step (4) into a purification tank, continue natural chromatography, and filter to obtain th...
Embodiment 2
[0034] A method for optimizing the extraction of total flavonoids from jasmine by response surface methodology, the process steps are:
[0035] (1) Crushing of raw materials: crushing jasmine stems with a roller press;
[0036] (2) Impregnation: Put 50 kg of broken stems into the extraction tank, then add 750 kg of dimethyl carbonate solvent with a pH value of 5.5, and impregnate for 20 minutes;
[0037] (3) Extraction: After immersion, heat up to 92°C, start ultrasonic wave, control the frequency to 40 kHz, and control the time for 25 minutes, filter, re-extract the filter residue twice, and combine the filtrate;
[0038] (4) Separation: put the combined filtrate of step (3) into a chromatographic tank for natural chromatography for 0.8 hours, then discharge the solvent and continue to use it for the next batch of production;
[0039] (5) Purification: Add the extract of total flavonoids of jasmine separated in step (4) into a purification tank, continue natural chromatograp...
Embodiment 3
[0041] A method for optimizing the extraction of total flavonoids from jasmine by response surface methodology, the process steps are:
[0042] (1) Crushing of raw materials: crushing jasmine leaves with an extruder;
[0043] (2) Impregnation: Put 50 kg of broken jasmine leaves into the extraction tank, then add 900 kg of dimethyl carbonate solvent with a pH value of 5.8, and impregnate for 15 minutes;
[0044] (3) Extraction: After immersion, under the condition of raising the temperature to 90°C, start the ultrasonic wave, control the frequency to 48 kHz, and control the time for 20 minutes, filter, re-extract the filter residue once, and combine the filtrate;
[0045] (4) Separation: put the combined filtrate of step (3) in a chromatography tank for natural chromatography for 0.5 hours, and discharge the solvent to continue to be used in the next batch of production;
[0046] (5) Purification: Add the extract of total flavonoids of jasmine separated in step (4) into a purifi...
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