The invention discloses a ventilator air pressure adjustment and monitoring system and its application, which are used to adjust and monitor the ventilator air pressure. It includes an air supply unit, a control unit, an air guide unit and a patient circuit unit. The control unit includes a data acquisition module, Data processing module and data sending module, the air supply unit includes a speed regulation module for adjusting the speed of the fan, the air guide unit includes a sensing module, a secondary pressure regulating module, a temperature regulating module and a humidity regulating module, and the sensing module is used to detect the initial value And output values, including gas pressure, gas temperature, gas humidity and gas flow rate, the patient circuit unit includes a breathing detection module, which is used to detect the patient's breathing and other vital signs, and the data acquisition module is used to collect the sensing module and the breathing detection module The data processing module analyzes and processes the data of the data acquisition module, sends the processing results to the data sending module, and the data sending module sends the processing information to the air guide unit for air pressure adjustment.