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Natural antiseptic solid dispersoid prepared by using leaves of vaccinium bractum thunb and preparation method

A technology of solid dispersion and black rice leaves, applied in application, food science, food preservation, etc., can solve the problems of poor solubility, high cost, and few varieties, and achieve good solubility, low cost, and easy material extraction. Effect

Inactive Publication Date: 2015-06-10
JIANGSU YONGZHANG WEIYE HEALTH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention utilizes the excellent antiseptic effect of the leaves of the black rice tree, aims at the shortcomings of high cost and few varieties of the current natural preservatives, overcomes the disadvantages of poor solubility of the extract of the black rice tree leaves, and prepares a natural antiseptic with good solubility, safety and stability. Anticorrosive Solid Dispersion

Method used

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  • Natural antiseptic solid dispersoid prepared by using leaves of vaccinium bractum thunb and preparation method
  • Natural antiseptic solid dispersoid prepared by using leaves of vaccinium bractum thunb and preparation method

Examples

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Effect test

Embodiment 1

[0030] This embodiment is a preparation method of a natural antiseptic solid dispersion prepared by utilizing the leaves of black rice leaves, and the steps of the preparation method are:

[0031] (1) Preparation of the extract: add 6 times the volume of ethanol to the leaves of the black rice tree, and the ethanol is ethanol with a concentration of 20% by volume; cold immersion or heating and reflux extraction once, each time for 12 hours, to obtain the extract;

[0032] (2) Concentrated extract: filter and combine the extract obtained in the previous step, and then concentrate to 0.25g crude drug / mL to obtain a concentrated extract;

[0033] (3) Through the macroporous resin: filter or centrifuge the concentrated extract obtained in the previous step and pass through the AB-8 macroporous resin. 1BV / h, the ratio of diameter to height of resin is 1:3;

[0034] (4) Wash the resin with water: wash the resin obtained in the previous step with 3BV of water, the elution flow rate ...

Embodiment 2

[0040] This embodiment is a preparation method of a natural antiseptic solid dispersion prepared by utilizing the leaves of black rice leaves, and the steps of the preparation method are:

[0041] (1) Prepare the extract: add 12 times the volume of ethanol to the leaves of the black rice tree, and the ethanol is ethanol with a concentration of 95% by volume; extract by cold soaking or heating and refluxing 4 times, each time for 0.5 hours, to obtain the extract;

[0042] (2) Concentrated extract: filter and combine the extract obtained in the previous step, and then concentrate to 1.0 g crude drug / mL to obtain a concentrated extract;

[0043] (3) Through macroporous resin: filter or centrifuge the concentrated extract obtained in the previous step and pass through D 101 Macroporous resin, the amount of concentrated extract is added according to the mass ratio of raw materials and dry resin is 1:5, the flow rate of the upper column is 4BV / h, and the ratio of resin diameter to h...

Embodiment 3

[0050] This embodiment is a preparation method of a natural antiseptic solid dispersion prepared by utilizing the leaves of black rice leaves, and the steps of the preparation method are:

[0051] (1) Prepare the extract: add 9 times the volume of ethanol to the leaves of the black rice tree, and the ethanol is ethanol with a concentration of 45% by volume; extract by cold soaking or heating and reflux twice, each time for 5.5 hours, to obtain the extract;

[0052] (2) Concentrated extract: filter and combine the extract obtained in the previous step, and then concentrate to 0.55 g crude drug / mL to obtain a concentrated extract;

[0053] (3) Through macroporous resin: filter or centrifuge the concentrated extract obtained in the previous step and pass through AB-8 macroporous resin. It is 2BV / h, and the diameter-to-height ratio of the resin is 1:7;

[0054] (4) Wash the resin with water: wash the resin obtained in the previous step with 5BV of water, the elution flow rate is ...

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Abstract

The invention discloses a natural antiseptic solid dispersoid prepared by using leaves of vaccinium bractum thunb and a preparation method. According to the preparation method of the solid dispersoid, after ethanol is added to the leaves of the vaccinium bractum thunb, a cooling reflux extraction or a heating reflux extraction is carried out; the extracting solution is filtered, merged and concentrated; the concentrated extracting solution is subjected to filtration or centrifugation, and then passes through macroporous resin; washing is carried out on the resin by using water, and a water eluent is discarded; the resin is eluted by the ethanol, and an ethanol eluent is collected; the ethanol eluent is subjected to decompressed concentration and drying, and an extractive of the leaves of the vaccinium bractum thunb is obtained; by adopting a melting method, the solid dispersoid is prepared by the extractive of the leaves of the vaccinium bractum thunb. By utilizing the excellent antiseptic effect of the leaves of the vaccinium bractum thunb, the defects in current natural antiseptic that the cost is high and the variety is few are targeted, the defects that the solubility of the extractive of the leaves of the vaccinium bractum thunb is overcome, and the natural antiseptic solid dispersoid which is good in solubility, safe and stable is prepared.

Description

technical field [0001] The invention relates to an antiseptic substance and a preparation method thereof, in particular to a natural antiseptic solid dispersion prepared by utilizing the leaves of black rice tree and a preparation method thereof. Background technique [0002] Food spoilage refers to the changes in the composition and sensory properties of food under the action of various factors mainly caused by microorganisms, resulting in food quality degradation or loss of edible value, and even food poisoning. In recent years, the economic losses caused by the rot and deterioration of food such as agricultural and sideline products, aquatic products, fruits and vegetables all over the world are very huge. Therefore, the preservation and preservation of food has always been an important problem to be solved in the food industry. Long-term studies have found that chemical preservatives commonly used now have more or less toxic effects such as carcinogenicity and teratogeni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L3/3472
Inventor 张琳张大伟李卫国李锡敏黄河叶昌荣
Owner JIANGSU YONGZHANG WEIYE HEALTH TECH
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