Natural antiseptic solid dispersoid prepared by using leaves of vaccinium bractum thunb and preparation method
A technology of solid dispersion and black rice leaves, applied in application, food science, food preservation, etc., can solve the problems of poor solubility, high cost, and few varieties, and achieve good solubility, low cost, and easy material extraction. Effect
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Embodiment 1
[0030] This embodiment is a preparation method of a natural antiseptic solid dispersion prepared by utilizing the leaves of black rice leaves, and the steps of the preparation method are:
[0031] (1) Preparation of the extract: add 6 times the volume of ethanol to the leaves of the black rice tree, and the ethanol is ethanol with a concentration of 20% by volume; cold immersion or heating and reflux extraction once, each time for 12 hours, to obtain the extract;
[0032] (2) Concentrated extract: filter and combine the extract obtained in the previous step, and then concentrate to 0.25g crude drug / mL to obtain a concentrated extract;
[0033] (3) Through the macroporous resin: filter or centrifuge the concentrated extract obtained in the previous step and pass through the AB-8 macroporous resin. 1BV / h, the ratio of diameter to height of resin is 1:3;
[0034] (4) Wash the resin with water: wash the resin obtained in the previous step with 3BV of water, the elution flow rate ...
Embodiment 2
[0040] This embodiment is a preparation method of a natural antiseptic solid dispersion prepared by utilizing the leaves of black rice leaves, and the steps of the preparation method are:
[0041] (1) Prepare the extract: add 12 times the volume of ethanol to the leaves of the black rice tree, and the ethanol is ethanol with a concentration of 95% by volume; extract by cold soaking or heating and refluxing 4 times, each time for 0.5 hours, to obtain the extract;
[0042] (2) Concentrated extract: filter and combine the extract obtained in the previous step, and then concentrate to 1.0 g crude drug / mL to obtain a concentrated extract;
[0043] (3) Through macroporous resin: filter or centrifuge the concentrated extract obtained in the previous step and pass through D 101 Macroporous resin, the amount of concentrated extract is added according to the mass ratio of raw materials and dry resin is 1:5, the flow rate of the upper column is 4BV / h, and the ratio of resin diameter to h...
Embodiment 3
[0050] This embodiment is a preparation method of a natural antiseptic solid dispersion prepared by utilizing the leaves of black rice leaves, and the steps of the preparation method are:
[0051] (1) Prepare the extract: add 9 times the volume of ethanol to the leaves of the black rice tree, and the ethanol is ethanol with a concentration of 45% by volume; extract by cold soaking or heating and reflux twice, each time for 5.5 hours, to obtain the extract;
[0052] (2) Concentrated extract: filter and combine the extract obtained in the previous step, and then concentrate to 0.55 g crude drug / mL to obtain a concentrated extract;
[0053] (3) Through macroporous resin: filter or centrifuge the concentrated extract obtained in the previous step and pass through AB-8 macroporous resin. It is 2BV / h, and the diameter-to-height ratio of the resin is 1:7;
[0054] (4) Wash the resin with water: wash the resin obtained in the previous step with 5BV of water, the elution flow rate is ...
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